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Symmetrel

Symmetrel is a medication used to treat dyskinesia associated with parkinsonism and influenza caused by type A influenzavirus, though its use for the latter is no longer recommended due to widespread drug resistance.

Other names for this medication:
Amantadine, Amantral, Amantrel, Comantrel, Neaman

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Also known as: Amantadine

Description

Generic Symmetrel is an antiviral medication. It blocks the actions of viruses in your body. Generic name of Generic Symmetrel is Amantadine. Symmetrel is also known as Amantadine. Brand name of Generic Symmetrel is Symmetrel.

Dosage

This section provides information on the proper use of a number of products that contain amantadine. It may not be specific to Symmetrel. Please read with care.

For patients taking amantadine for Parkinson's disease or movement problems (including dyskinesia) caused by certain medicines used to treat nervous, mental, and emotional conditions:

Take this medicine exactly as directed by your doctor. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered. This medicine comes with a Medication Guide or patient information leaflet. Read and follow these instructions carefully. Ask your doctor if you have any questions. Do not stop using this medicine suddenly without asking your doctor. You may need to slowly decrease your dose before stopping it completely. Improvement in the symptoms of Parkinson's disease usually occurs in about 2 days. However, in some patients, this medicine must be taken for up to 2 weeks before the full benefit is seen.

For patients taking amantadine to prevent or treat flu infections:

Talk to your doctor about the possibility of getting a flu shot if you have not had one yet. This medicine is best taken before exposure or right away after exposure to people who have the flu. To help keep yourself from getting the flu, keep taking this medicine for the full time of treatment. Or if you already have the flu, continue taking this medicine for the full time of treatment even if you begin to feel better after a few days. This will help clear up your infection completely. If you stop taking this medicine too soon, your symptoms may return. This medicine should be taken for at least 2 days after all your flu symptoms have disappeared. This medicine works best when there is a constant amount in the blood. To help keep the amount constant, do not miss any doses. Also, it is best to take the doses at evenly spaced times at day and night. For example, if you are to take two doses a day, the doses should be spaced about 12 hours apart. If this interferes with your sleep or other daily activities, or if you need help in planning the best times to take your medicine, check with your doctor. If you are using the oral liquid form of amantadine, use a marked measuring spoon, oral syringe, or medicine cup to measure each dose correctly. The average household teaspoon may not hold the right amount of liquid.

Take Gocovri® extended-release capsule at bedtime. Swallow whole. Do not crush, break, or chew it. You may also open and sprinkle the extended-release capsules on a teaspoonful of soft food, including applesauce. Take all of the medicine right away without chewing. You may take this medicine with or without food.

Take Osmolex ER™ extended-release tablet in the morning. Swallow whole. Do not crush, open, or chew it.

Do not receive the nasal flu vaccine (live attenuated influenza vaccine) while taking this medicine.

Do not drink alcohol while you are using this medicine.

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

For treatment of Parkinson's disease or movement problems (including dyskinesia): For oral dosage forms (extended-release capsules): Adults—137 milligrams (mg) once a day at bedtime. Your doctor may increase your dose to 274 mg (two 137 mg capsules) once a day at bedtime after one week. Children—Use and dose must be determined by your doctor. For oral dosage forms (extended-release tablets): Adults—129 milligrams (mg) once a day in the morning. Your doctor may increase your dose each week to a maximum dose of 322 mg (one 129 mg tablet and one 193 mg tablet) once a day taken in the morning. Children—Use and dose must be determined by your doctor. For oral dosage forms (liquid-filled capsules, syrup, and tablets): Adults—100 milligrams (mg) 2 times a day. Your doctor may adjust your dose as needed. Older adults—At first, 100 milligrams (mg) once a day as a single dose. Your doctor may adjust your dose as needed. Children—Use and dose must be determined by your doctor. For the treatment or prevention of flu: For oral dosage forms (capsules, syrup, and tablets): Adults—200 milligrams (mg) or 4 teaspoonfuls once a day as a single dose. Older adults—100 milligrams (mg) once a day as a single dose. Children 9 to 12 years of age—100 milligrams (mg) or 2 teaspoonfuls 2 times a day. Children 1 to 9 years of age—Dose is based on body weight and must be determined by your doctor. The usual dose is 4.4 to 8.8 milligrams (mg) per kilogram (kg) of body weight per day. The dose is divided evenly and given 2 times a day. However, the dose is usually not more than 150 mg per day. Children younger than 1 year of age—Use and dose must be determined by your doctor.

Overdose

If you overdose Generic Symmetrel and you don't feel good you should visit your doctor or health care provider immediately.

Storage

Store at room temperature between 20 and 25 degrees C (68 and 77 degrees F) away from moisture and heat. Keep container tightly closed. Throw away any unused medicine after the expiration date. Keep out of the reach of children.

Side effects

The most common side effects associated with Symmetrel are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of amantadine in the elderly. Elderly patients are also more likely to have unwanted effects (eg, falls, hallucinations) and age-related kidney disease, which may require caution in patients receiving Gocovri® and Osmolex ER™.

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We have previously observed that pole walking does not lead to a reduction of the load on the knee joint. Sequential intramolecular epitope spreading of humoral responses to human BPAG2 in a transgenic model. Reach Out Churches: A Community-Based Participatory Research Pilot Trial to Assess the Feasibility of a Mobile Health Technology Intervention to Reduce Blood Pressure Among African Americans. Atopic dermatitis is associated with significant patient burden, with impacts from symptoms and visible physical manifestations of the disease. Photosensitization of optical fiber and silica-on-silicon/silica waveguides. Presynaptic and postsynaptic cortical mechanisms of chronic pain. The aim of therapeutic help in marital crisis is to break the vicious circle of mutual hurtful accusations.

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Streptokinase appears to be highly effective in the treatment of iatrogenic superior vena cava syndrome from Hickman catheters. Strong genetic drift in small and fragmented populations of these 2 species could be related to the origin and maintenance of the large polymorphism of sex chromosomes. Macrophages play vital roles in chronic liver injury, and have been tested as a tool for cytotherapy in liver fibrosis. In mucous metaplasia of the mouse stomach, Cx32 was mainly expressed in the cytoplasm of epithelial cells. Many of the features of EGS make worthwhile the re-investigation of Clostridium botulinum Group III toxins, which are known to prevent vesicular exocytosis, stimulate neurosecretion, produce neuronal chromatolysis and inhibit neutrophil migration. In the present paper, we estimated the difference between the integration times required to detect the dichoptic motion and monocular motion by changing the duration of the stimulus. To characterize the pneumatization of the temporal bone in age-matched healthy children and in children with otitis media with effusion (OME). This decreased cardiac mass was associated with a reduction in stroke volume, but cardiac output was maintained by a compensatory increase in heart rate. If I were you: contribution to the study of projective identification. PP13 mRNA expression in the cellular component of maternal blood as a marker for preeclampsia.

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Response of ovine uterine blood flow to epinephrine and norepinephrine. Reinforcing and phencyclidine-like stimulus properties of enantiomers of metazocine. The prevention of HIV-1-associated disease is highly relevant to the abrogation of the neoplastic processes associated with this pathogen. This review will discuss updates in surgical techniques, outcome comparisons, cost analysis, and the continued role of extracapsular cataract extraction in Western countries. We determined that the medialis pedis flap was a remarkable alternative for palmar reconstruction of the hand and digits due to burn because of its glabrous skin, which was very similar to palmar skin, and low donor site morbidity. Coinfection of Spodoptera exigua and Spodoptera frugiperda cell lines with the nuclear polyhedrosis viruses of Autographa californica and Spodoptera exigua. Mutations at residue, T20 and T24 affected the binding of hMAbs, 8G8 and 5G12 only. ER and PR gene expression was analyzed in the endometrium, myometrium and vagina of postmenopausal women treated with estriol.

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We describe our fully-coupled 3D multiscale model of in-stent restenosis, with blood flow simulations coupled to smooth muscle cell proliferation, and report results of numerical persantine medication with stroke simulations performed with this model. Similar to the polymers in the solution, citrate ions also dynamically adsorbed on the growing silver nanoparticles and promote one (1-D) and two-dimensional (2-D) growth of nanoparticles. Type 6 septal deformity is almost a rule in children suffering from UCLP. Risk stratification for elderly patients with acute decompensated heart failure (ADHF) may help clinicians to select the appropriate therapy and raise the quality of care. Described here are a series of four cases of congenital high airway obstruction in the fetus.

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Eleven healthy subjects, aged 21-38 y, participated in an 8-wk, randomly assigned, crossover study that involved the ingestion of supplemental doses of cinnamon and turmeric for 4-wk periods that provided 55 mg oxalate/d. For targets, compensatory discrimination-categorization processes (reflected on P3 amplitudes) were sufficient to override our mild transient hypoxic challenge. After incomplete surgery, post-operative BFV might aid in identifying patients who may benefit of post-operative therapy. SUMMARYTurkey is the only country in Europe where urban dog-mediated rabies persists. In this direction we investigated, in some regions of the rat gastrointestinal tract, the presence and localization of aquaporin-6, given its peculiar function as an ion selective channel. Are axial intervertebral disc biomechanics determined by osmosis?. Spontaneous hemorrhage into an extralobar bronchopulmonary sequestration. Chain length effect on the structure and stability of antimicrobial peptides of the (RW)n series. Using a collagenase, DNAse/pronase digestion technique, hepatic parenchymal and nonparenchymal cell fractions were obtained from livers of in vivo rG-CSF pretreated Sprague-Dawley rats 2 h after LPS exposure. The rather dramamine interaction with alcohol low correlations between studies indicate that cross-laboratory comparison and standardization are pressing issue to assure high-quality and comparable growth-rate data.

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A survey is presented of picosecond kinetics of heme-residue bond formation after photolysis of histidine, methionine, or cysteine, in a broad range of ferrous six-coordinate heme proteins. A number of polypeptides were studied on the rat aortic ring preparation which was pre-contracted with phenylephrine and only basic polypeptides containing one or more arginine residues elicited relaxation which was endothelium dependent. The study showed that colour Doppler measurements are reliable if the images for analysis are selected by anatomical position in combination with colour Doppler activity and the subsequent analysis is performed in an area defined by anatomical structures. The hydrogenotrophic order, Methanobacteriales, predominated in both reactors under all applied operational conditions. Role of serotonin in the pathogenesis of acute and chronic pulmonary hypertension. sirtalis is indeed predisposed to evolving TTX resistance, it also indicates that the potential exists in sympatric congeners not expressing elevated levels of TTX resistance. These algorithms are the subject of active research and controversy.

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Cultured hypopharyngeal epithelial (FaDu) cells were exposed to human pepsin (0.1 mg/mL) at pH 7.4 for either 1 hour or 12 hours at 37 degrees C and analyzed by electron microscopy, cytotoxicity assay, and SuperArray. Effects of Src inhibitors on cell growth and epidermal growth factor receptor and MET signaling in gefitinib-resistant non-small cell lung cancer cells with acquired MET amplification. Lymphoblastic sarcoma of the inferior concha associated with a tuberculous cervical polyadenopathy. Analysis which antibiotic is safe to use with coumadin of the expression pattern of the BCL11B gene and its relatives in patients with T-cell acute lymphoblastic leukemia. It is ubiquitous, and following resolution of primary productive infection, it persists in the human host by establishing a lifelong latent infection in myeloid lineage cells such as monocytes and their progenitors. The channel bridging, signal regenerating, and functional rebuilding of injured nerves is one of the most important issues in life science research. The graft was evaluated for use as both a bypass and arteriovenous (AV) access graft. A dialysate flow rate of 300 ml/min made it possible to increase the urea nitrogen mass transfer rate from 10 to 65 mg/min and the clearance from 10.5 to 37.5 ml/min. Pathogenic T cells have a paradoxical protective effect in murine autoimmune diabetes by boosting Tregs.

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