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Sovaldi (Sofosbuvir)
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Sovaldi

Sovaldi is used with other antiviral medications (such as Sovaldi, peginterferon, daclatasvir) to treat chronic (long-lasting) hepatitis C, a viral infection of the liver. It works by reducing the amount of hepatitis C virus in your body, which may help your liver recover. Chronic hepatitis C infection can cause serious liver problems such as scarring (cirrhosis), or liver cancer.

Other names for this medication:
Sofosbuvir

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Kemadrin, Bactrim, Dramamine, Avodart, Reminyl, Noroxin, Diamox, Xalatan, Viramune, Norep, Ribomin, Seegraf, Catier, Tegrital,

Also known as: Sofosbuvir

Description

Sovaldi (sofosbuvir) is an antiviral medication that prevents hepatitis C virus (HCV) from multiplying in your body.

Sovaldi is used to treat chronic hepatitis C in adults and children who are at least 3 years old.

Sovaldi must be given in combination with other antiviral medications (usually ribavirin with or without peginterferon alfa). It should not be used alone.

Sovaldi treats specific genotypes of hepatitis C, and only in certain people. Use only the medications prescribed for you. Do not share your medicine with other people.

Sovaldi is sometimes used in people who also have HIV, or people who have liver cancer and are going to have a liver transplant. This medicine is not a treatment for HIV or AIDS.

Dosage

Usual Adult Dose for Chronic Hepatitis C:

400 mg orally once a day Recommended Regimen and Duration of Therapy: -Genotype 1 or 4: Sofosbuvir, peginterferon alfa, and ribavirin for 12 weeks -Genotype 2: Sofosbuvir and ribavirin for 12 weeks -Genotype 3: Sofosbuvir and ribavirin for 24 weeks -Hepatocellular carcinoma awaiting liver transplantation: Sofosbuvir and ribavirin for up to 48 weeks or until liver transplantation (whichever occurs first) Comments: -Genotype 1, 4: This regimen is recommended for therapy-naive patients without cirrhosis or with compensated cirrhosis (Child-Pugh A). -Genotype 2, 3: Both regimens are recommended for therapy-naive and therapy-experienced patients without cirrhosis or with compensated cirrhosis (Child-Pugh A). -Therapy-experienced patients have failed an interferon-based regimen (with or without ribavirin). -The dose recommendations for genotype 1, 2, 3, or 4 should be followed for HCV/HIV-1-coinfected patients. -The manufacturer product information should be consulted for ribavirin tablet dose recommendations; with genotype 1 or 4, the manufacturer product information for peginterferon alfa should also be consulted for dose recommendations. -Sofosbuvir and ribavirin for 24 weeks can be considered for patients with genotype 1 infection who cannot use an interferon-based regimen; treatment decision should be guided by benefit/risk assessment for the individual patient. -The regimen for patients with hepatocellular carcinoma awaiting liver transplantation is recommended to prevent posttransplant HCV reinfection. Use: As a part of a combination antiviral treatment regimen, for the treatment of chronic HCV infection -In combination with pegylated interferon and ribavirin: For genotype 1 or 4 infection without cirrhosis or with compensated cirrhosis -In combination with ribavirin: For genotype 2 or 3 infection without cirrhosis or with compensated cirrhosis

Usual Pediatric Dose for Chronic Hepatitis C:

3 years or older: -Weight less than 17 kg: 150 mg orally once a day -Weight 17 to less than 35 kg: 200 mg orally once a day -Weight at least 35 kg: 400 mg orally once a day Recommended Regimen and Duration of Therapy: -Genotype 2: Sofosbuvir and ribavirin for 12 weeks -Genotype 3: Sofosbuvir and ribavirin for 24 weeks -Hepatocellular carcinoma awaiting liver transplantation: Sofosbuvir and ribavirin for up to 48 weeks or until liver transplantation (whichever occurs first) Comments: -Both regimens are recommended for therapy-naive and therapy-experienced patients without cirrhosis or with compensated cirrhosis (Child-Pugh A). -Therapy-experienced patients have failed an interferon-based regimen (with or without ribavirin). -The manufacturer product information should be consulted for ribavirin dose recommendations. -The same dose recommendations should be followed for HCV/HIV-1-coinfected patients. -The regimen for patients with hepatocellular carcinoma awaiting liver transplantation is recommended to prevent posttransplant HCV reinfection. Use: In combination with ribavirin, for the treatment of chronic HCV genotype 2 or 3 infection in patients without cirrhosis or with compensated cirrhosis

Detailed Sovaldi dosage information

Overdose

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Detailed Sovaldi dosage information

Side effects

The most common side effects associated with Sovaldi are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

You should not use Sovaldi if you are allergic to sofosbuvir. When taking Sovaldi with other medicine: To make sure all medicines are safe for you, tell your doctor about all your medical conditions, and if you are pregnant or breastfeeding.

To make sure Sovaldi is safe for you, tell your doctor if you have ever had:

hepatitis B (you may be tested for this before you take sofosbuvir); a liver transplant; liver problems other than hepatitis C; kidney disease (or if you are on dialysis); HIV or AIDS; a heart rhythm problem for which you take a medicine called amiodarone; or if you use a blood thinner (warfarin, Coumadin, Jantoven) and you have routine "INR" or prothrombin time tests.

Sovaldi is sometimes used in combination with ribavirin. Both men and women using ribavirin should use effective birth control to prevent pregnancy. Ribavirin can cause birth defects, miscarriage, or death to an unborn baby if the mother or father is using this medicine.

You should not take ribavirin if you are pregnant, or if you are a man and your sex partner is pregnant. Use effective birth control to prevent pregnancy. Keep using birth control for at least 6 months after your last dose of ribavirin.

Tell your doctor right away if a pregnancy occurs while either the mother or the father is using ribavirin.

It may not be safe to breastfeed while using Sovaldi. Ask your doctor about any risk.

Sovaldi is not approved for use by anyone younger than 3 years old.

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The influence of L-carnitine suplementation on the antioxidative abilities of serum and the central nervous system of ethanol-induced rats. High-density collagen gel tubes as a matrix for primary human bladder smooth muscle cells. THE GUILLEBAUD Committee: memorandum of evidence from the Royal College of Physicians. Tapes japonica lysozyme (TJL), which belongs to the invertebrate-type lysozyme family, has a unique dimer formation. The most fundamental objection is that healthcare resources should be allocated in accordance with need, not with merit. Structure-activity relationship study of leberagin-C suggested that there are some important amino acid differences with jararhagin, the most studied PIII metalloprotease from Bothrops jararaca, notably around the SECD motif in its disintegrin-like domain. Other natural compounds, extracts from medicinal plants employed in ethnomedicine and displaying marked anti-herpetic activity, are at present under investigation to determine the scientific evidence and rationale for their clinical use. Gene silencing of DNA methyltransferases by RNA interference in bovine fibroblast cells. Enhanced 5-fluorouracil cytotoxicity in high cyclooxygenase-2 expressing colorectal cancer cells and xenografts induced by non-steroidal anti-inflammatory drugs via downregulation of dihydropyrimidine dehydrogenase. Penetrating neck injuries: experience with selective exploration.

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