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Motrin (Ibuprofen)

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Motrin is a non-steroidal anti-inflammatory drug (NSAID). It works by blocking the release of certain chemical messengers that cause fever, pain and inflammation (redness and swelling).

Other names for this medication:
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Also known as: Ibuprofen


Diphenhydramine is an antihistamine. Ibuprofen is a nonsteroidal anti-inflammatory drug (NSAID).

Motrin PM is a combination medicine used to treat occasional insomnia associated with minor aches and pains. Motrin PM is not for use in treating sleeplessness without pain, or sleep problems that occur often.

Motrin PM is for use in adults and children at least 12 years old.


This section provides information on the proper use of a number of products that contain ibuprofen. It may not be specific to Motrin. Please read with care.

For safe and effective use of this medicine, do not take more of it, do not take it more often, and do not take it for a longer time than ordered by your doctor. Taking too much of this medicine may increase the chance of unwanted effects, especially in elderly patients .

When used for severe or continuing arthritis, this medicine must be taken regularly as ordered by your doctor in order for it to help you. This medicine usually begins to work within one week, but in severe cases up to two weeks or even longer may pass before you begin to feel better. Also, several weeks may pass before you feel the full effects of this medicine .

To lessen stomach upset, you may take this medicine with food or milk .

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

For oral dosage form (tablets and suspension): For fever: Children over 2 years of age—Use and dose must be determined by your doctor. Children 6 months of age up to 2 years—Dose is based on body weight and body temperature, and must be determined by your doctor. For fever lower than 102.5 °F (39.2 °C), the dose usually is 5 milligrams (mg) per kilogram (kg) (about 2.2 mg per pound) of body weight. For higher fever, the dose usually is 10 mg per kg (about 4.5 mg per pound) of body weight. The medicine may be given every six to eight hours, as needed, up to 40 mg per kg per day. Infants younger than 6 months of age—Use and dose must be determined by your doctor . For menstrual cramps: Adults—400 milligrams (mg) every four hours, as needed. Children—Use and dose must be determined by your doctor . For mild to moderate pain: Adults and teenagers—400 milligrams (mg) every four to six hours, as needed. Children over 6 months of age—Dose is based on body weight and must be determined by your doctor. The dose usually is 10 milligrams (mg) per kilogram (kg) of body weight every six to eight hours, as needed, up to 40 mg per kg per day. Infants younger than 6 months of age—Use and dose must be determined by your doctor . For osteoarthritis and rheumatoid arthritis: Adults and teenagers—1200 milligrams (mg) up to 3200 mg per day divided into three or four equal doses. Children—Dose is based on body weight and must be determined by your doctor. The dose usually is 30 milligrams (mg) to 40 mg per kilogram (kg) of body weight per day, divided into three or four doses. Infants younger than 6 months of age—Use and dose must be determined by your doctor .


Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.


Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Detailed Motrin Childrens dosage information

Side effects

The most common side effects associated with Motrin are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


Appropriate studies have not been performed on the relationship of age to the effects of ibuprofen in children below 6 months of age. Safety and efficacy have not been established .

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Computer-interactive method for quantifying cerebrospinal fluid and tissue in brain CT scans: effects of aging. Amniotic fluid cells from normal and abnormal fetuses (neural tube defects and abdominal wall lesions) were examined uncultured and after short-term culture for macrophages. We investigated the membrane motion at the leading edge of red blood cells in detail and showed that this technique can achieve simultaneous manipulation and detection of cellular edge dynamics with unprecedented precision. In this paper a hit rate of 0.7 is achieved by the Morphological contour detectors which are comparable with the other two methods. The effects of diethylstilbestrol and medroxyprogesterone acetate on kinetics and production of testosterone and dihydrotestosterone in patients with prostatic carcinoma. An Experience from Pre- and Post-treatment Study with Missing Data. Immunoelectron microscopic localization of a tumor-associated antigen (TAA) in the canine transmissible venereal sarcoma by anti-TAA-antiferritin hybrid antibodies. Since the goal of those involved in medical education and patient care is to perform at the highest possible level, we offer twelve practical tips for making the best use of feedback in order to support learners of all levels. After transurethral resection of a superficial bladder tumor 63 patients were treated by chemoprophylaxis with mitomycin C over a period of two years: 33.3 percent experienced recurrent disease under metaphylaxis and 42 patients who remained recurrence-free during instillation therapy were observed further for an average of 26.4 months. To address the highly elevated levels of heavy metals found in Asian and non-Asian dust, studies should be performed to assess the potential impacts of settled particles on surface ecosystems, water resources, and human health in Korea.

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