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Indocin (Indomethacin)
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Indocin

Indocin is used to treat moderate to severe pain, swelling, tenderness, and stiffness caused by osteoarthritis, rheumatoid arthritis, and ankylosing spondylitis. It can also be used for gout attacks and shoulder busitis or tendonitis.

Other names for this medication:
Artid, Artisid, Donica, Ducain, Edcin, Idicin, Indmecin, Indoc, Indocap, Indocid, Indoflam, Indol, Indomethacin, Indonet, Indopar, Indoriv, Inmecin, Inocin, Methadocin, Microcid, Recticin, Tissop

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Also known as: Indomethacin

Description

Indomethacin is a nonsteroidal anti-inflammatory drug (NSAID) used to help relieve symptoms of moderate to severe arthritis (eg, osteoarthritis and rheumatoid arthritis) or gout, such as inflammation, swelling, stiffness, and joint pain. However, this medicine does not cure arthritis and will help you only as long as you continue to use it.

Indomethacin is also used to treat moderate to severe ankylosing spondylitis, which is a type of arthritis that affects the joints in the spine. This medicine may also be used to treat painful shoulder caused by bursitis or tendinitis.

This medicine is available only with your doctor's prescription.

Dosage

This section provides information on the proper use of a number of products that contain indomethacin. It may not be specific to Indocin. Please read with care.

For safe and effective use of this medicine, do not use more of it, do not use it more often, and do not use it for a longer time than your doctor ordered. Using too much of this medicine may increase the chance of unwanted effects.

This medicine should come with a Medication Guide. Read and follow these instructions carefully. Ask your doctor if you have any questions.

When used for severe or continuing arthritis, this medicine must be used regularly as ordered by your doctor in order for it to help you. This medicine usually begins to work within one week, but in severe cases up to two weeks or even longer may pass before you begin to feel better. Also, several weeks may pass before you feel the full effects of this medicine.

Do not take rectal suppositories by mouth or use it in the vagina.

To use the suppository:

If the suppository is too soft to insert, chill it in the refrigerator for 30 minutes or run cold water over it before removing the foil wrapper. Remove the foil wrapper and moisten the suppository with cold water. Lie down on your side and use your finger to push the suppository well up into the rectum Remain lying down for about 15 minutes to keep the suppository from coming out before it melts. Make sure to wash your hands with soap and water before and after inserting this medicine.

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

For rectal dosage form (suppositories): For moderate to severe ankylosing spondylitis, osteoarthritis, or rheumatoid arthritis: Adults and children older than 14 years of age—One 50-milligram (mg) suppository, inserted into the rectum up to 3 times a day. Children up to 14 years of age—Use and dose must be determined by your doctor. For acute painful shoulder caused by bursitis or tendinitis: Adults and children older than 14 years of age—One suppository inserted into the rectum 3 to 4 times a day. Children up to 14 years of age—Use and dose must be determined by your doctor. For gout: Adults and children older than 14 years of age—One suppository inserted into the rectum 3 times a day. Children up to 14 years of age—Use and dose must be determined by your doctor.

Overdose

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Overdose symptoms may include severe drowsiness, stomach pain, or vomiting.

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Detailed Indocin dosage information

Side effects

The most common side effects associated with Indocin are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

No information is available on the relationship of age to the effects of indomethacin injection in geriatric patients.

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Antiphospholipid syndrome (APS) is similar to HIT in that it is mediated by autoantibodies that are also prothrombotic. Therapy with 2,3-dimercaptopropane-1-sulfonate was effective in these two patients. Consequently, these fixed internal errors will remain uncorrected. The influence of stimulus movements on perception in parafoveal stabilized vision. The OPD, Bahawal Victoria Hospital, Bahawalpur, from September 2000 to January 2004. Frictional wear characteristics of biomedical Ti-29Nb-13Ta-4.6Zr alloy with various microstructures in air and simulated body fluid.

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The aim of this study is to report a series of 12 laparoscopic upper-pole partial nephrectomies, to highlight the feasibility of a single-setting treatment for this rare condition. Compared with normotensive controls, hypertensive participants demonstrated increased late/early ejection-phase MWS and reduced LA function. Quantum dots, dye-doped polymer and silica particles have found many applications in biochemical protocols and are extensively discussed in the literature. To fulfill the requirement for HSCT, international collaborations as well as domestic efforts are considered to be important for the future. A PCF, also called a holey fiber or microstructured fiber, is an optical fiber which consists of a periodic array of very tiny and closely spaced air holes on the scale of 1 microm running through the whole length of the fiber. We suggest that relative stability of IL in old age may reflect neural reorganization that compensates for age-related losses in striatal functions. The aim of this study was to examine the effects of two important proinflammatory cytokines released during H. When a preoperative diagnosis is made, a conservative treatment is recommendable, including frozen sections analysis of the cyst and adjacent testicular parenchyma to rule out a coexistent intratubular germ cell neoplasia.

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Rapid changes in foveal sensitivity resulting from direct and indirect adapting stimuli. The numerous advantages of BS have prompted applications not only in the food, cosmetic, and pharmaceutical industries but in energy and environmental technologies as well. Cellulose pretreatment in subcritical water: effect of temperature on molecular structure and enzymatic reactivity. To review the nature and outcomes of acute severe proptosis in patients after craniofacial trauma, over a 6-year period. DARPins comprise a novel class of binding molecules suitable to complement or even replace antibodies in many biotechnological or biomedical applications. Evaluation of the risk of infection through exposure to aerosols and spatters in dentistry. Epindolidione, a hydrogen-bonded derivative of the organic semiconductor tetracene, is an organic pigment which has previously been used to produce stable OFETs with relatively high hole mobilities.

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Comparison between arthroscopic and open synovectomy for the knee in rheumatoid arthritis. Body weight regulation in ground squirrels and hypothalamically lesioned rats: slow and sudden set point changes. Increased fibrin monomer level is an independent predictor of mortality in patients with myocardial infarction. In each session, subjects undertook a bout of intense one-leg glycogen-depleting exercise followed by a 5-h recovery period during which they ingested a protein/carbohydrate mixture. Metal nanocrystals with highly branched morphologies are an exciting new class of nanomaterials owing to their unique structures, physicochemical properties, and great potential as catalysts, sensing materials, and building blocks for nanoscale devices. In the majority, therapy is based on inadequate indications, mainly continuous long-term therapy after previous variceal bleeding. However, the 2010 AHA Guidelines for Cardiopulmonary Resuscitation and Emergency Cardiovascular Care corrects this by changing the A-B-C of CPR to C-A-B, acknowledging that chest compressions are the most important aspect of the cardiac arrest management. Bypass reactions offer more scope for controlling and manipulating reaction conditions, e.g., redox potential, because they effectively isolate or decouple the Q-cycle initial reactions from later steps, preventing many complications and interactions. All of the analogs increased CREB transcription with forskolin stimulation up to twofold. A biphenyl privileged structure library containing three attachment points were synthesized using a catechol-based safety-catch linker strategy.

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In vivo, ethanol exposure caused both decreased angiogenesis and increased hypoxia in wounds. Complications do occur in the treatment of idiopathic scoliosis. At E16.5, kynurenate abolished the spontaneous bursts in the cervical VR. Evaluation of standardized routine documentation with implementation of the requirements of multicenter studies. Here we report the first evidence of germline activity in the mouse using a naturally active DNA transposon derived from the medaka fish called Tol2, as an alternative system for high-throughput forward genetic mutagenesis screening tool.

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Association between the physical activity of Korean adolescents and socioeconomic status. Fusion is indicated in cases with bad bony and soft tissue situation. Recently, much has been written about the challenges in implementing the concept of professionalism within healthcare delivery. Reverse total shoulder arthroplasty has become a widely accepted surgical procedure in Japan since the time when the implants were approved for use in 2014. Additive interaction of pentagastrin and secretin on pancreatic growth in rats.

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In our patients, BTH injection, involving the action of injecting under the skin acetylated morphine derivatives (mostly 6-monoacetylmorphine and 3-monoacetylmorphine), was associated with the development of botulism. Pathomechanism of true hermaphroditism in the light of observed cases. Health effects of an efficient vented stove in the highlands of Guatemala. To study the inductive effects of aluminum (Al) on metallothioneine (MT) in rats. Nevertheless, the pollen dispersal pattern of dipterocarp, main canopy tree species in palaeo-tropical forest remains unclear, and flowering intensity variation in the field suggests heterogeneity of fecundity. Effect of dorsal midbrain lesion in infant rats on development of circadian rhythm. Thus, UV damage to keratinocytes of the epidermis may participate in the destruction of collagen in the dermis by release of soluble mediators that signal fibroblasts to release MMP-1. Gene expression analysis by reverse-transcription quantitative PCR (RT-qPCR) has been a key enabling technology of the post-genome era. We computed polytomous logistic regression models to examine the relationship between communication (communication about tests, communication about sexual and intimate relationships), barriers to screening, and on-schedule BCCS among unmarried women. Conversely, isolated infradiaphragmatic cutaneous metastases are exceedingly rare and are associated with an aggressive clinical course.

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Subsequently a model predicting 30-day mortality was created and compared with the performance of the GUSTO-I and TIMI models. Subsequently, eight species of gut bacteria were fed to larvae, and RNA-based DGGE analysis of 16S rRNA was used to detect the persistence of these isolates in the hindgut environment. A high temperature piezoelectric ceramic: (1-x)(Bi0.9La0.1)FeO(3-x)PbTiO3 crystalline solutions. The degree of acetylation of pectin can be modulated by pectin acetylesterase (EC 3.1.1.6, PAE). The environmental complexity seems to constitute a strong stimulator competent to rescue the diabetic brain from neurodegenerative progression. Experience with Reiter type of electric coma at the Boston Psychopathic Hospital. The ingestion of foreign bodies is the second most frequent cause of aorto-esophageal fistulization after aneurysms of the thoracic aorta. Colonization of the skin of patients with atopic dermatitis (AD) by Staphylococcus aureus (SA) is associated with more severe disease. Here, we established mutant cells that were selectively defective in transport of GPI-APs from the ER to the Golgi. Then, a complete tumour resection should be performed using the most careful incision possible to avoid postoperative complications.

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Role of quantitative endotracheal aspirate and cultures as a surveillance and diagnostic tool for ventilator associated pneumonia: a pilot study. Provinces of Alberta and British Columbia, and their TB registries. An unusual filamentous component associated with the guinea pig sperm middle piece. Characterization of antimicrobial properties of Salmonella phage Felix O1 and Listeria phage A511 embedded in xanthan coatings on Poly(lactic acid) films. However, this success came at heavy toll, requiring harsh cytoreductive regimen and a balance tipped toward graft-versus-host reactivity.

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If penumbral tissue can be conclusively identified, endovascular treatment in proximal and intracranial tandem occlusion can be successful, even in treatments initiated 6-9 h after stroke onset. Our results support the hypothesis of the existence of physiological TWA levels, which are to be considered in the effort to improve reliability of nonphysiological TWA levels discrimination. The CRE infections occured in patients with substantial comorbidities and were associated with high mortality and low rates of clinical cure with available antibiotics. Containment wells facilitate the formation of hydraulic barriers. The associations between cigarette smoking and health-related behaviors among Chinese school-aged adolescents.

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Patients determined to have KL grade 4 OA by any rater on extension AP radiographs were excluded. While the individual protein Tim9 forms a homodimer, Tim10 is a monomer. These results suggest that lePrxV and lePrxVI play protective roles against oxidative stress caused by thermal exposure. In addition, several slices of images have been obtained as proofs by using the multislice two-dimensional spin echo sequence through replacement of the conventional soft pulse by the proposed P/N pulse. Our PS matching analysis showed that VATET is a reliable and effective surgical approach alternative to T-3b in patients with MG who are candidates for thymectomy.

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Eye-hand-coordination: a model for computing reaction times in a visually guided reach task. While the success rate for genotyping of a common SNP in MTHFR was similar to the hybridization probe approach, the HRM based method was more cost-effective and had a shorter turnaround time. Iatrogenic injury to the infrapatellar branch of the saphenous nerve (IPBSN) is associated with many surgical interventions to the medial aspect of the knee, such as anterior cruciate ligament (ACL) reconstruction. These results suggest close associations between resting state brain activity in the prefrontal and striatal regions and specific personality traits and thus contribute to the understanding of the zebeta 5 mg equivalent neurobiological bases of predisposition to psychiatric disorders. In addition, we demonstrate that dicarbonyls can attenuate the inflammatory signaling induced by tumor necrosis factor-alpha in a reporter cell system. Patients were divided into non-corticosteroid and low dose corticosteroid treated groups after elimination of patients with concomitant disease or therapy which might affect bone mass.

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RPA-Mediated Recruitment of the E3 Ligase RFWD3 Is Vital for Interstrand Crosslink Repair and Human Health. The molecular mechanisms governing reparative dentinogenesis are yet to be fully understood. Our results suggest implanting a heavy metals biomonitoring program in the TSB marine ecosystems. A generative model of interacting neuronal ensembles for ERPs was inverted in a scheme allowing investigation of the connections from and to the SPL, how long should i not drink alcohol after taking flagyl a multisensory processing area. In contrast to microorganisms, plant products mostly contain glucose, galactose, rhamnose and xylose as structural elements. Limited evidence suggests also that the two loci encoding for the s-MDH-A subunit are each polymorphic and linked or pseudolinked. Hepatic vein bullet embolus as a complication of left thoracic gunshot injury.

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