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Imitrex (Sumatriptan)

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Imitrex is used to treat the symptoms of migraine headaches (severe, throbbing headaches that sometimes are accompanied by nausea or sensitivity to sound and light). Imitrex is in a class of medications called selective serotonin receptor agonists.

Other names for this medication:
Migratan, Sumatriptan, Suminat, Sumitrex

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Also known as: Sumatriptan


Sumatriptan is used to treat acute migraine headaches in adults. It is not used to prevent migraine headaches and is not used for cluster headaches. Sumatriptan works in the brain to relieve the pain from migraine headaches. It belongs to the group of medicines called triptans.

Many people find that their headaches go away completely after they take sumatriptan. Other people find that their headaches are much less painful, and that they are able to go back to their normal activities even though their headaches are not completely gone. Sumatriptan often relieves other symptoms that occur together with a migraine headache, such as nausea, vomiting, sensitivity to light, and sensitivity to sound.

Sumatriptan is not an ordinary pain reliever. It will not relieve pain other than from migraine headaches. This medicine is usually used for people whose headaches are not relieved by acetaminophen, aspirin, or other pain relievers.

Sumatriptan has caused serious side effects in some people, especially people who have heart or blood vessel disease. Be sure that you discuss with your doctor the risks of using this medicine as well as the benefits that it can have.

This medicine is available only with your doctor's prescription.


Usual Adult Dose for Migraine:

Use only after a clear diagnosis of migraine has been established Oral: Initial dose: 25 mg, 50 mg, or 100 mg orally, once -If some response to first dose occurs, a second dose may be administered at least 2 hours after first dose if needed -Oral doses of 50 and 100 mg may provide greater relief than 25 mg; however, a 100 mg dose may not provide greater effect than a 50 mg dose Maximum dose: 200 mg per 24 hours Intranasal: Nasal spray: Initial dose: 5 mg, 10 mg, or 20 mg into one nostril, once -Administer the 5 and 20 mg doses as a single spray in 1 nostril; the 10 mg dose may be administered as 5 mg into each nostril -If some response to first dose occurs, a second dose may be administered at least 2 hours after first dose if needed Maximum dose: 40 mg per 24 hours Comments: -Treatment should be started at the first sign of a migraine headache, or associated symptoms such as nausea, vomiting, or photophobia; this drug should not be used for migraine prophylaxis. -Higher doses may have a greater effect, but also carry a greater risk of adverse reactions. -The safety of treating an average of more than 4 headaches in a 30 day period has not been established. Use: For the acute treatment of migraine with or without aura.

Detailed Imitrex dosage information


Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Overdose symptoms may include tremors, skin redness in your arms or legs, weakness, loss of coordination, breathing problems, blue-colored lips or fingernails, vision problems, or a seizure (convulsions).


Store at room temperature between 2 and 30 degrees C (36 and 86 degrees F) away from moisture and heat. Throw away any unused medicine after the expiration date. Keep out of the reach of children.

Side effects

The most common side effects associated with Imitrex are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


Appropriate studies have not been performed on the relationship of age to the effects of sumatriptan injection in the pediatric population. Use of Imitrex® is not recommended in children. Safety and efficacy have not been established.

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Selective biliary obstruction: a model for the study of lipid metabolism in cholestasis. Differential effects of cytokines and corticosteroids on toll-like receptor 2 expression and activity in human airway epithelia. Indifferent urogenital complexes were excised from mouse foetuses assessed by developmental criteria as day 10.5 or 11. KL28 and belongs to the superfamily of type I extradiol dioxygenases. EDOT-capped sigma3-phosphole self-rigidifies due to an unprecedented P-O interaction and can be electropolymerised affording functionalizable polymers.

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Any immunosuppressant or immunomodulatory treatment including corticosteroids, azathioprine, methotrexate, ciclosporin, chlorambucil, cyclophosphamide, intravenous immunoglobulin, interferon and plasma exchange was considered. Predictors of oral health-related quality of life in patients with temporomandibular disorders. Staining with the fluorochrome D 287/170 did not preferentially highlight any of the DA-DAPI positive regions in any of them. Compliance to the treatment remains an important factor of prognosis. These CMR data show that LA dimensions and volume in healthy, individuals vary significantly by BSA, with lesser effects of age and gender. Correlation between respiratory dz and intrathoracic physiological events. Experiments confirmed the role of derivative H as substrate/inhibitor of fungal transporter Cdr1p relating to increased sensitivity to fluconazole. Ultraviolet irradiation (uvR) has been demonstrated to have profound effects on many functions of the immune system. Follow-up surveys were conducted to determine implant survival and patient-reported outcomes. The authors describe a case of a newborn with HLHS, whose diagnosis was made after birth because of early respiratory failure.

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Anatomic considerations for splenic salvage during distal pancreatectomy are reviewed. Together with our previous work on post-ER localization of peptide-receptive class I molecules, our results suggest that loading of peptides onto class I molecules in the context of the peptide-loading complex can occur outside the ER. Discharge eligibility scores were higher in the nicotine group at 48 and 72 h compared with the control group, but the time to return to work was 19 days in both treatment groups. These changes must be kept in mind for the L-T3 measurement in rat serum. Any outbreak of an Office International des Epizooties trade-disrupting (previously List-A) disease, such as classical swine fever or foot and mouth disease in a previously disease-free region can have severe consequences for nonhuman animal welfare.

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The levels of thermospermine are around 6-fold lower than those of spermine in Arabidopsis seedlings. Thirty-six patients with pathology in the area of the craniocervical junction and the cervical spine have been studied with Magnetic Resonance Imaging (MRI), using the Inversion Recovery and Spin-Echo technique. In this study we use genetic methods to compare dispersal patterns in a British and a Swiss population that differ in their ecology and demography. Cell-free DNA from human plasma and serum differs in content of telomeric sequences and its ability to promote immune response. The crystallization mechanism of the polymerizing chain was discussed. The patient reported alterations in alcohol- and cocaine-seeking along with changes in defensive behaviour, including suicidal tendencies. The determination of the crystal structures of the two title polymorphs of 20-desmethyl-beta-carotene allows information to be gained regarding the structural effects on the polyene chain, as well as on the end groups, versus that of the parent compound beta-carotene. This novel finding may impact the clinical interpretation of CPX data in patients with HF who also present with this chronic pulmonary condition.

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A comparative study on the cellular processing of free and gold-conjugated transferrin. Timing therapeutic donor inseminations in natural cycles: human chorionic gonadotrophin administration versus urinary LH monitoring. From 2002 to 2007 the rate of inpatient cardiac catheterization procedures declined. In our experience protocol C is the most suitable in terms of patient compliance, impact of surgical procedures, and work organization, and is granted by an appropriate DRG. The H70 includes an age-homogeneous sample (127 cases and 255 non-cases) initially assessed at age 70 with 12 follow-ups over 30 years.

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Examples include improvements in monitoring and preventing osteoporosis in patients on long-term systemic corticosteroids, the detection of those at risk for azathioprine toxicity bowing to low thiopurine methyltransferase activity, and the addition of agents such as mycophenolate mofetil and IVIG to our therapeutic armamentarium. Specifically, the active site loop containing His-248 exhibits positional changes upon binding of the substrate and establishes a hydrogen-bonding network with Tyr-257, which is near the hydroxyl group of the substrate. Although extremely rare both in our experience and in the literature, benign metastasizing leiomyofibroma is an important differential diagnosis in young women seen with multiple lung nodules. In the high-dose (80 mg/kg) and medium-dose (40 mg/kg) groups, the kinetic profile of PUE in blood and kidney samples showed two absorption peaks, while that of the other tissues showed only one peak. Here we have examined potential selectivity of RGS2, 3 and 4 against signalling mediated by G alpha q/11-coupled muscarinic M3 receptors and gonadotropin-releasing hormone in an immortalised mouse pituitary cell line. Anti-perforin neutralizing antibody reduces myocardial injury in viral myocarditis.

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Action of cocarboxylase and vitamin B1 on carbohydrates in experimental fatigue. Efficacy of dutasteride, alfuzosin or both on Quality of Life in patients with prostatic hyperplasia and BOO.A two-year spontaneous, observational, self-controlled study. A total of 293 patients underwent the TVT operation and 80 patients the IVS operation. The microbiological activity of thymus peptide is destroyed by acid or alkaline hydrolysis and also by trypsin digestion, but is unaffected by pepsin digestion. NASs can be used as alternative sweeteners for controlling blood glucose levels and weight gain. A woman with unresectable squamous cell carcinoma of the thymus was treated with combination chemotherapy consisting of cyclophosphamide, adriamycin, cisplatin, and prednisone. albenza 200 mg Trp29 mutations significantly reduced the apparent V(max) and/or increased the apparent K(m) values for adenosine transport. In addition, ATF4(-/-) mice experienced significantly smaller infarcts and improved behavioral recovery as compared with wild-type mice subjected to the same reductions in blood flow in a rodent model of ischemic stroke.

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Chemical genetics identifies c-Src as an activator of primitive ectoderm formation in murine embryonic stem cells. The aim of this study was to evaluate the levels of cystatin C, interleukin-1beta (IL-1beta), and tumor necrosis factor-alpha (TNF-alpha) in the total saliva and gingival crevicular fluid (GCF) of periodontally healthy children (PHC) and children with gingivitis (CG) who were between 11 and 16 years old. Autolytic changes of human white matter: an electron microscopic and electrophoretic study. Serum levels of IGF-I, IGFBP-3 and colorectal cancer risk: results from the EPIC cohort, plus a meta-analysis of prospective studies. Aggregation of biological particles under radial directional guidance. However, mechanisms governing HSC recruitment to injured hepatic microcirculation are poorly understood. Instrumental neutron activation analysis for mercury in dogs administered methylmercury chloride: use of a low energy photon detector.

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The receptor path of an autonomous system is distinguished and the aims that could be achieved by preliminary modification of a carrier of information are discussed. Human immunodeficiency virus controllers (HICs) form a heterogeneous group of patients with regard to formal definitions, immunologic characteristics, and changes over time in viral load. The euchromatic organization of DXZ4 on the otherwise heterochromatic Xi, its binding of CTCF, and its function as a unidirectional insulator suggest that this macrosatellite has acquired a novel function unique to the process of X chromosome inactivation. Metabolic syndrome, with its increasing prevalence, is becoming a major public health problem throughout the world. The synchronization of the multiple interaction modalities results from a unique scene representation or model. Indeed, inbreeding level seems to be an important factor affecting the intra-plant spatial distribution of mites. Genetic and immunochemical study of Legionella strains isolated in Sverdlovsk region.

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It was established that portosystemic encephalopathy (PSE) is caused by the portosystemic shunts occurrence resulting in lowering of the volumetric blood flow in portal vein and hepatic artery, the diameter and intraluminal pressure in portal vein are diminished. Different mouse models developed recently indicate that miR-155 plays a critical role during hematopoiesis and regulates lymphocyte homeostasis and tolerance. Shedding light on zwitterionic magnetic nanoparticles: limitations for in vivo applications. The role of helicopter transport (HT) in civilian trauma care remains controversial. In the mouse pituitary glands, IGF-I mRNA and IGF-I receptor mRNA were detected by reverse transcription-polymerase chain reaction (RT-PCR). Hypothyroidism in immature rats was associated with markedly reduced myocardial beta-adrenoceptor density, lower content of the long isoform (Gsalpha-L) of the stimulatory G protein and increased amounts of Gialpha2 and Gialpha3. Detailed perioperative parameters were obtained from chart records. This review summarizes results of cost-utility analyses done with newer versus older antidepressants as well as atypical versus conventional/typical neuroleptics/antipsychotics. Moreover, they achieve good accuracy in both annotation and detection.

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To investigate epivir the malignant potential of oral lichen planus (OLP) on the basis of expression of the Fas/FasL markers in healthy individuals (H), OLP patients and patients with squamous cell carcinoma (SCC). Our data can assist planning for the treatment of patients during the winter in the Northern Hemisphere. In vivo efficacy of pyridone 16 by dose-dependent inhibition of histamine release was demonstrated in a rodent pharmacodynamic model of mast cell activation. The role of ultimobranchial bodies in the modulation of the response of chick embryos to 1,25-dihydroxy-cholecalciferol. GIT-27NO significantly inhibited the expression of the transcription repressor and apoptotic resistant factor YY1 and, in parallel, augmented the presence of total p53. Epithelial mesenchymal transition (EMT) has long been associated with breast cancer cell invasiveness and evidence of EMT processes in clinical samples is growing rapidly. Comparative cradle-to-grave life cycle assessment of biogas production from marine algae and cattle manure biorefineries. The major interactions are found to be between the substituted benzenes and the aromatic ring of a nearby phenylalanine residue. Portable electrical thermostat and its application in rural conditions.

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