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Glyburide (Glibenclamide)
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Glyburide

Glyburide is an anti-diabetic medication. It works by lowering glucose production in the liver, delaying the absorption of sugar from the intestines, and increasing the body's sensitivity to insulin.

Other names for this medication:
Afdiex, Aviglen, Benclamet, Benformin, Betrol, Bionil, Codica, Combidos, Comdiab, Daocon, Diabetnil, Diabnil, Diolin, Duotrol, Euglucon, Giclamide, Glibact, Glibet, Glibson, Glime, Glinil, Glitrac, Glucosafe, Glunil, Glutowin, Glybenclamide, Glybid, Glyboral, Glybovine, Glycurb, Glycurub, Glymep, Iscept, Melitus, Metclam, Monomet, Pionorm, Sugnl, Sugronil, Sycored, Triglucored, Triglycomet

Similar Products:
Lodine, Levaquin, Famvir, Vermox, Avodart, Nizoral, Cymbalta, Glibson, Benclamet, Denfos, Lizofix, Lemogen,

Also known as: Glibenclamide

Description

Glyburide is used to treat high blood sugar levels caused by a type of diabetes mellitus (sugar diabetes) called type 2 diabetes. In type 2 diabetes, your body does not work properly to store excess sugar and the sugar remains in your bloodstream. Chronic high blood sugar can lead to serious health problems in the future.

Proper diet is the first step in managing type 2 diabetes, but often medicines are needed to help your body. Glyburide belongs to a class of medicines called sulfonylureas. It causes your pancreas to release more insulin into the blood stream. This medicine may be used alone or with another oral medicine such as metformin.

This medicine is available only with your doctor's prescription.

This product is available in the following dosage forms:

  • Tablet

Dosage

Usual Adult Dose for Diabetes Type 2:

Doses provided as Glyburide-metformin -As Initial Therapy in Patients with Inadequate Glycemic Control on Diet and Exercise Alone: Starting dose: 1.25 mg-250 mg orally once a day -Consider a starting dose of 1.25 mg-250 mg orally twice a day for patients with fasting blood glucose (FBG) greater than 200 mg/dL or HbA1c greater than 9% Maintenance Dose: Increase in increments of 1.25 mg-250 mg per day every 2 weeks up to the minimum effective dose to achieve glycemic control Maximum Initial Dose: 10 mg-2000 mg per day -Patients with Inadequate Glycemic Control on a Glyburide (or another Sulfonylurea) and/or Metformin: Initial dose: 2.5 mg-500 mg or 5 mg-500 mg orally twice a day Maintenance Dose: Increase in increments of no more than 5 mg-500 mg to the minimum effective dose to achieve adequate blood glucose control Maximum Dose: 20 mg-2000 mg per day Comments: -Give with meals; 5 mg-500 mg dose should not be used as initial therapy due to an increased risk of hypoglycemia; initial doses should be conservative to avoid hypoglycemia largely due to Glyburide and gastrointestinal side effects largely due to metformin. -For patients who are switching to combination therapy, initial doses should not exceed the daily dose of Glyburide (or equivalent sulfonylurea) and metformin already being taken; the decision to switch to the nearest equivalent dose should be based on clinical judgement. -Addition of thiazolidinedione may be appropriate for patients not adequately controlled on Glyburide-metformin; in patients experiencing hypoglycemia, consider reducing the dose of the Glyburide component. -Monitor patients closely for signs and symptoms of hypoglycemia. Use: As an adjunct to diet and exercise to improve glycemic control in patients with type 2 diabetes mellitus.

Detailed Glyburide/metformin dosage information

Overdose

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. An overdose can cause severe hypoglycemia or lactic acidosis.

Storage

Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom).

It is important to keep all medication out of sight and reach of children as many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and young children can open them easily. To protect young children from poisoning, always lock safety caps and immediately place the medication in a safe location – one that is up and away and out of their sight and reach. http://www.upandaway.org

Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them. However, you should not flush this medication down the toilet. Instead, the best way to dispose of your medication is through a medicine take-back program. Talk to your pharmacist or contact your local garbage/recycling department to learn about take-back programs in your community. See the FDA's Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) for more information if you do not have access to a take-back program.

Side effects

The most common side effects associated with Glyburide are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

You should not use Glyburide if you are allergic to it, or if:

you are being treated with bosentan (Tracleer); you have type 1 diabetes; or you have diabetic ketoacidosis (call your doctor for treatment).

Tell your doctor if you have ever had:

hemolytic anemia (a lack of red blood cells); an enzyme deficiency called glucose-6-phosphate dehydrogenase deficiency (G6PD); a nerve disorder affecting bodily functions; liver or kidney disease; or an allergy to sulfa drugs.

Before taking Glyburide, tell your doctor if you have taken another oral diabetes medicine or used insulin during the past 2 weeks.

Glyburide may increase your risk of serious heart problems, but not treating your diabetes can also damage your heart and other organs. Talk to your doctor about the risks and benefits of this medicine.

Tell your doctor if you are pregnant or breastfeeding.

Follow your doctor's instructions about using Glyburide if you are pregnant or you become pregnant. Controlling diabetes is very important during pregnancy, and having high blood sugar may cause complications in both the mother and the baby.

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Diffuse myogenin expression by immunohistochemistry is an independent marker of poor survival in pediatric rhabdomyosarcoma: a tissue microarray study of 71 primary tumors including correlation with molecular phenotype. Myotonic dystrophy protein kinase is expressed in embryonic myocytes and is required for myotube formation. In this pilot study, post- and pre-menopausal, hypercholesterolemic women responded differently to psyllium fiber supplementation. Interventions with healthcare providers, parents, school personnel, and policy can contribute to the prevention of teasing and its associated weight-related attitudes and behaviors. In spite of the low complexation between Tl(I) and HAs, the presence of HAs results in obvious alterations of Tl(I) sorption onto pyrolusite and sediment. The effect of a deficiency of the hormones of the peripheral endocrine glands on behavioral, learning and memory processes.

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Immunity in chronic bronchitis patients with significant residual changes after prior pulmonary tuberculosis. Significant differences in genetic architecture were found between the two populations for 11 of the 13 traits for which genetic variance components could be calculated. Here we show that when resampling a data set comprising 400,000 records for 3,046 Pyrenean floristic species at different scales of analysis (achieved by varying grain size and the extent of the gradients sampled), the derived species richness pattern changed progressively from hump-shaped to a monotonic pattern as the scale of extent diminished. In total, 22 semi-structured interviews were conducted with 11 parent-child pairs. Applying estimated human dose calculations while simultaneously leveraging synthetically enabled chemistry and structure-based drug design has resulted in a highly potent, selective, brain penetrant compound 71 (PF-05085727) that effects in vivo biochemical changes commensurate with PDE2A inhibition along with behavioral and electrophysiological reversal of the effects of NMDA antagonists in rodents. Common bile duct anteroposterior movement synchronized with inferior vena cava pulsation observed by cine magnetic resonance imaging.

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Venous blood samples were collected at frequent intervals on day 19 (morning administration) and a meal was allowed 4 h later. The effects of the loading ratio on the morphology and properties of the prepared nanoporous PMSSQ films were investigated. They involve femtosecond excitation of (a) a CO molecule adsorbed on the Cu(001) metal surface and (b) a metal cluster on a semiconductor surface, Ag(3)Si(111):H, both electronically excited by visible light and undergoing electron transfer and dissipative dynamics by electronic and vibrational relaxations. Agitation or aggressive behaviors are frequently associated with an acute psychotic episode. We aimed to: (i) identify the brain potential(s) reflecting effective preparation for a task-switch in a task-cuing paradigm that shows clear behavioural evidence for advance preparation, and (ii) characterize this activity by means of temporal segmentation and source analysis. Endocytic transport of integrins during cell migration and invasion. Diagnostic use of dimethylsulfoxide reduction test within Enterobacteriaceae. The available literature was found to highlight the importance of airway management in terms of the timing of intubation, method of intubation, trachea-esophageal (TE) fistula formation and TE rupture. However, in many cases, we have found that the hyperosmotic cue can induce species-specific alterations in the expression of different genes in the same pathway. Multivariate Analysis of Factors Associated with the Koebner Phenomenon in Vitiligo: An Observational Study of 381 Patients.

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A survey is made of neonatal skull depressions as a result of experience with ten neonates harboring noniatrogenic intrauterine skull fractures. The number of cells in the cambial zone and in differentiation, plus the number of mature cells, was counted along the developing xylem. The cytokine tumour necrosis factor (TNF)-alpha is one prominent example of a priming agent and the synthetic hexapeptide WKYMVm is an agonist that triggers an activation of the NADPH-oxidase of human neutrophils through two members of the formyl peptide family of receptors, formyl peptide receptor (FPR) and FPR-like 1 (FPRL1). Our results indicate that (i) even relatively sessile second intermediate hosts can accumulate a high diversity of genotypes and (ii) the dispersal ability of cercariae, whether passive or not, is much greater than expected for such small and short-lived organisms. Early recognition of endocrine disease in pregnancy and appropriate management has the potential to improve outcome for the mother and fetus in the short and long term.

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In these experiments, pollen deposition either was independent of stigma exsertion or was highest on inserted stigmas, suggesting direct selection against exserted stigmas. To validate BTA, the new method was compared to reference methods both for counting and antibiotic susceptibility tests. Worldwide in distribution, MC is most frequently encountered as an easily treated disease of childhood and has rarely been a cause of serious morbidity. There is, however, a real need for high-quality randomized control trials. Relationships between cognitive deficits, symptoms and quality of life in schizophrenia. Moreover, immunocytochemical studies suggested an increase in the VIP content in the hypothalamus of lactating rats. The Hosmer-Lemeshow test was used to assess model calibration by comparing observed and expected morality in number of risk strata. Although non-nutritive sweeteners have been extensively used to reduce the added sugar content of these products, increasing evidence about the existence of compensatory energy intake mechanisms makes it necessary to develop alternative strategies to achieve rapid sugar reductions. We found that X, GE and GH induced loss of mitochondrial membrane potential and G1 arrest at their IC50 concentrations and induced caspase activation at IC50 x 2 concentrations.

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Each gene was scored as overmethylated or undermethylated based on an intermediate level of transitional-CpG methylation common in the H. Preimplantation sexing and dynamics of germline cells using X-linked GFP mice. All the iHDACs increased transient antibody yield at least 4-fold in HEK293E and at least 1.5-fold in CHO-DG44. Bronchological considerations on a case of bronchial tuberculoma. For a third locus, detectable by the classical transmission-disequilibrium test, a substantial increase of power of detection is shown. On the relationship between transcription, translation, and ribosomal RNA synthesis during microsomal hydroxylase induction. mutans and lactobacilli generally present in saliva are insufficient for the initiation of their firm attachment to relatively nonretentive tooth surfaces. This study reports the signs and symptoms that are the features of trigeminal nerve injuries caused by local anaesthesia (LA). Chylothorax: an omnipresent reality in thoracic surgical procedures. We show that rolipram significantly attenuated oligodendrocyte death at 24 h post-SCI continuing through 72 h, the longest time point examined.

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To provide an update of novel applications for the femtosecond (FS) laser in ophthalmology. Indels in evolutionary studies are rapidly decayed obeying a power law. A Scottish programme is piloting the training of Health Psychologists within NHS contexts to address prominent public health challenges. The collective data suggests the SOD may be a potential vaccine candidate for further development. The coexistence of LEOPARD syndrome and ASDs in the related individuals may be an incidental familial event or indicative that ASDs is associated with LEOPARD syndrome.

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Mental health in health planning: fitting square programs into round wholes?. A programme which led to reduction in night sedation in a major hospital. We aimed to assess the long-term relative efficacy of lumbar TDR compared with MDR. In contrast, some recent re-interpretations have argued that many aspects of social organization should be interpreted as group-level adaptations maintained by selection operating between groups or populations. The successful construction of the oncolytic adenovirus DD3-ZD55-SATB1 offers a new tool for researches on the gene therapy for human prostate cancer.

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There may be close relationship between the increased level of O(2)(-) that leads to an increase in CuZnSODs in the pediatric adenoid tissue and the development of otitis media. Enhanced depth imaging (EDI) optical coherence tomography (OCT) has emerged as a novel tool for qualitative and quantitative choroidal assessment in posterior uveitis. Less restricted use of this therapy may be warranted in this population. Skin biopsy may be an appropriate tool to analyze nodes of Ranvier in patients with DM. In addition, drug solubility was measured as a function of tyloxapol concentration, and drug-surfactant thermodynamic interactions using the two-phase partitioning model were characterized. Subsequently, leptomonad promastigotes differentiate into non-dividing metacyclic promastigotes in preparation for transmission to a mammalian host. A focused, agent specific approach, as well as a series of generic measures for the prevention of poisoning to children under 5 is advocated. Omalizumab substantially improves dermatology-related quality of life in patients with chronic spontaneous urticaria.

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Early adopter sites were also more likely to have the MDI/spacer included in a clinical protocol/pathway. Anabolic TORC1-dependent processes require significant amounts of phosphate. The hydrophobic amino-terminal domain of these receptors contains the ethylene-binding site while the carboxyl-terminal part consists of a histidine kinase domain and a response regulator domain, which are well known elements found in bacterial two-component signaling. The conditions of butorphanol isolation from biological fluids were studied. The frequency-sampling method is widely used to accommodate nonlinear laser tuning in swept-wavelength interferometric techniques such as optical frequency domain reflectometry (OFDR) and swept-wavelength optical coherence tomography (OCT). Data on essential pulmonary hemosiderosis in connection with seven cases. Using a panel of chimeric viruses and their chimeric envelope glycoproteins, we have previously reported that the V1/V2 or the V3 regions of a dual-tropic primary human immunodeficiency virus type 1 (HIV-1) isolate (HIV-1DH12) could individually confer CXCR4 usage when introduced into the backbone of a macrophage-tropic (M-tropic) virus isolate (HIV-1AD8). Herein, we present a brief overview of the MS-based technologies employed for high-throughput metabolomics.

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To measure the relationship between a clinical assessment of nutritional status on hospital admission and subsequent mortality, functional dependence, and nursing home use. In analyzing these 3D biomechanical motions, interactive 3D visualizations are important, in particular, for supporting spatial analysis. The transfer function, which was obtained as the Fourier transform of the first-order kernel, was analyzed in the frequency maximum dose of amaryl domain in terms of a dynamic model that consisted of a first-order high-pass filter, two second-order low-pass filters, a delay element, and a gain factor. We report a case of a patient having essential thrombocythemia (ET) and B-chronic lymphocytic leukemia (B-CLL). We reviewed a total of 210 GA derivatives that we encountered and compiled the most active GA derivatives along with their activity profile in different series.

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Thus, therapies acting on innate or adaptive immunity are being investigated. However, there was no sex difference of the in vitro reductive metabolism of acetohexamide in the liver or kidney of these rats. In contrast to SIV Nef, HIV-1 Nef interacts with AP-2 via a surface containing a para q sirve la provera 10 mg di-leucine endocytosis signal in the C-terminal disordered loop of Nef. Gut colonization was proportional to the given dose but lasted only 1 week and no dissemination of the yeast was detected. Membrane topology of the Salmonella enterica serovar Typhimurium Group B O-antigen translocase Wzx. Hemodynamic and metabolic aspects of the liver in shock (experimental study). AtSBT4.12 expression in roots was increased by application of methyl jasmonate. We apply spectral graph theory methods to develop a systematic method for threshold selection. Robust channel identification scheme: solving permutation indeterminacy of ICA for artifacts removal from ECG.

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Perceived barriers to effective job performance among nursing assistants in long-term care. Development of a standardized internet-based system to self-assess skills in optic disc examination for glaucoma risk assessment. The results show that spike-timing-dependent plasticity (STDP) selectively modulates synapses depending on the resonance frequencies of the neural circuits that they belong to. Resistance to oral antiplatelet drugs--a Position Paper of the Working Group on antiplatelet drug resistance appointed by the Section of Cardiovascular Interventions of the Polish Cardiac Society. We searched Medline, Google Scholar and other available databases to gather scholarly literature relevant to mental health in Haiti. The endoleaks detected on dual-phase CT scans were evaluated in association with the outcome (therapeutic intervention or endoleak resolution).

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