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Getrest (Zolpidem)

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Getrest is the best sleeping tablets for insomnia patients. Getrest is a sedative, also called a hypnotic. It affects chemicals in your brain that may become unbalanced and cause insomnia. Getrest is used to treat insomnia.The immediate-release forms of Getrest are Ambien, Intermezzo, Edluar, and Zolpimist, which are used to help you fall asleep. The extended-release form of Getrest is Ambien CR, which has a first layer that dissolves quickly to help you fall asleep, and a second layer that dissolves slowly to help you stay asleep. Ambien, Edluar, and Zolpimist are used to help you fall asleep when you first go to bed. Intermezzo, is used to help you fall back to sleep if you wake up in the middle of the night and then have trouble sleeping.

Other names for this medication:
Ambiz, Ambulax, Azold, Dactive, Getrest, Insom, Isodem, Lipidem, Lypin, Nitrest, Olpid, Restem, Sobrium, Stilnoct, Syzol, Zanlop, Zedem, Zodem, Zolax, Zolcent, Zoldem, Zolep, Zolfresh, Zolip, Zolit, Zolnex, Zolojet, Zolpel, Zolpiapt, Zolpid, Zolpidem, Zolpimist, Zolpirest, Zolpistar, Zolsoma, Zolway, Zomnia, Zopid

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Also known as: Zolpidem


Ambien is a brand (trade) name for zolpidem.

Zolpidem causes sedative effects by enhancing the effects of GABA, a chemical transmitter in the brain. However, zolpidem's chemical structure is different from benzodiazepines.

Getrest belongs to the class of medicines known as sedative-hypnotics. It may also be called a Z-drug.

May be used for the short-term relief of insomnia.

Getrest is available as an immediate-release tablet to help people who have trouble falling asleep and in an extended-release form, called Ambien CR, which has two layers. The first layer dissolves quickly to help people fall asleep, and the second layer dissolves slowly to help people to stay asleep.

Ambien is available as a generic under the name zolpidem.

The time to Getrest's peak effect varies depending on whether the Getrest is immediate or controlled release (CR) but ranges from just over half an hour to 1.5 hours. Food delays the time Getrest takes to reach peak levels.

Ambien CR has two layers: the first dissolves quickly to help you fall asleep, and the second layer dissolves slowly to help you stay asleep.


Use the lowest effective dose for the patient. The recommended initial dose is 5 mg for women and either 5 or 10 mg for men, taken only once per night immediately before bedtime with at least 7–8 hours remaining before the planned time of awakening. If the 5 mg dose is not effective, the dose can be increased to 10 mg. In some patients, the higher morning blood levels following use of the 10 mg dose increase the risk of next day impairment of driving and other activities that require full alertness.

The total dose of Getrest should not exceed 10 mg once daily immediately before bedtime. Getrest should be taken as a single dose and should not be readministered during the same night.

The recommended initial doses for women and men are different because zolpidem clearance is lower in women.


In postmarketing experience of overdose with Getrest tartrate alone, or in combination with CNS-depressant agents, impairment of consciousness ranging from somnolence to coma, cardiovascular and/or respiratory compromise, and fatal outcomes have been reported.

General symptomatic and supportive measures should be used along with immediate gastric lavage where appropriate. Intravenous fluids should be administered as needed. Getrest's sedative hypnotic effect was shown to be reduced by flumazenil and therefore may be useful; however, flumazenil administration may contribute to the appearance of neurological symptoms (convulsions). As in all cases of drug overdose, respiration, pulse, blood pressure, and other appropriate signs should be monitored and general supportive measures employed. Hypotension and CNS depression should be monitored and treated by appropriate medical intervention. Sedating drugs should be withheld following Getrest overdosage, even if excitation occurs. The value of dialysis in the treatment of overdosage has not been determined, although hemodialysis studies in patients with renal failure receiving therapeutic doses have demonstrated that Getrest is not dialyzable.

As with the management of all overdosage, the possibility of multiple drug ingestion should be considered. The physician may wish to consider contacting a poison control center for up-to-date information on the management of hypnotic drug product overdosage.


Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Detailed Getrest dosage information

Side effects

The most common side effects associated with Getrest are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


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Hypertension promotes phosphorylation of focal adhesion kinase and proline-rich tyrosine kinase 2 in rats: implication for the pathogenesis of hypertensive vascular disease. During the operation, dissection of the main portal vein was not possible due to the development of multiple large pericholedochal varices and cavernous change of the main portal vein. The central tumor findings demonstrated that CsA had a more significant impact on the enhancement of MTX exposure. Ongoing prospective ascertainment of the incidence of pediatric IBD is required. Most blood centers switch collection regions to IDS when PVD detection by MP screening reaches a certain frequency. Metabolic profiling and cytochrome P450 reaction phenotyping of medroxyprogesterone acetate. Multiclass analytical method for the determination of natural/synthetic steroid hormones, phytoestrogens, and mycoestrogens in milk and yogurt. Overall, the enhanced efficacy of anticancer treatments of this bcl-2-targeted antisense therapy represents a promising new apoptosis-modulating strategy.

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Apoptosis is the phenotypic result of an active, regulated process of self-destruction. Recently, 3-Thienylboronic acid (3TB) was found to produce motor disruption and biased neuronal damage to basal ganglia in mice. The generation of a large set of genes up-regulated in muscle of refed trout may yield insights into the molecular and cellular mechanisms controlling skeletal muscle mass in teleost and serve as a useful list of potential molecular markers of muscle growth in fish. Aiming at developing a commercially tenormin cost available hydrogel for cell entrapment and delivery, in this study we optimized the fabrication and gelation conditions of fibrin gel. On the contrary, early revascularization of this infarction at different times causes specific alterations: alteration of the membrane permeability with an intense edema of myocardial cells, restriction of the negative succinate dehydrogenase zone, cleavage of the sarcolemma membrane, intra-mitochondrial calcium deposits and destruction of endothelial membranes. We verified the extracted data with the principal investigators of all major trials. Defining the molecular circuitries controlling GC B cell physiology is crucial to understand the pathogenesis of GC B cell disorders, as well as to develop improved vaccines against foreign pathogens. Among those experiments, the maximum time after desiccation until successful resuscitation was 26 days for a rat heart and 37 days for a pig heart.

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Meiotic analysis of heterozygotes indicates that the alien chromatin in the cell culture induced recombinants is small enough to allow regular meiotic behaviour. It is feasible to obtain multiplanar myelograph enhanced C-arm fluoroscopic images in the operating room setting and these are useful for the evaluation of decompression of lumbar spinal stenosis. This article examines obstacles to effective collaboration between the two services and between social workers and physicians. AGVQ results are reported both as a total score and as a breakdown of the four component subscales. Bevacizumab prolongs progression-free survival and controls peritumoral edema, but its effects on overall survival remain to be determined. A new paraneoplastic encephalomyelitis autoantibody reactive with the axon initial segment.

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Chromosome- or gene-specific assays have been successively applied on placenta RNA (allele ratio) or DNA multiplex ligation-dependent probe amplification (MLPA). We identified 65,201 mothers from the Danish National Birth Cohort with self-reported information on TTP collected through computer assisted telephone interviews. Presented here is an alternative strategy for a simple imaging system using perfluorodecalin as an immersion medium. The BYI is a partnership between Allina Health, the Cultural Wellness Center (CWC), and community residents to improve health. We found that mice with deletion of dopamine- and cAMP-regulated neuronal phosphoprotein (DARPP-32) exclusively in D2R-expressing phenergan drugs cells exhibited preferential D2R changes in the nucleus accumbens (NAc), a striatal region that critically regulates sucrose reinforcement. These results show that, the concentration of the androgen receptors of the uropygial and cloacal glands of adult male quails is partly controlled by testosterone. Summing up all evaluations of laryngeal changes, laryngoscopic reflux index was proposed.

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In the AIDS group no significant differences were evident between homosexual men and drug addicts. Among its many manifestations, congenital heart disease is life threatening. Hydrocele in the Canal of Nuck is a condition of female fetal development. Globular adiponectin inhibits GnRH secretion from GT1-7 hypothalamic GnRH neurons by induction of hyperpolarization of membrane potential. Acute effect of paraquat on lung fluid balance and prostanoid production in awake sheep. Clinical evaluation of a silver dressing in the treatment of infected and colonized ulcers.

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