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Getrest (Zolpidem)
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Getrest

Getrest is the best sleeping tablets for insomnia patients. Getrest is a sedative, also called a hypnotic. It affects chemicals in your brain that may become unbalanced and cause insomnia. Getrest is used to treat insomnia.The immediate-release forms of Getrest are Ambien, Intermezzo, Edluar, and Zolpimist, which are used to help you fall asleep. The extended-release form of Getrest is Ambien CR, which has a first layer that dissolves quickly to help you fall asleep, and a second layer that dissolves slowly to help you stay asleep. Ambien, Edluar, and Zolpimist are used to help you fall asleep when you first go to bed. Intermezzo, is used to help you fall back to sleep if you wake up in the middle of the night and then have trouble sleeping.

Other names for this medication:
Ambiz, Ambulax, Azold, Dactive, Getrest, Insom, Isodem, Lipidem, Lypin, Nitrest, Olpid, Restem, Sobrium, Stilnoct, Syzol, Zanlop, Zedem, Zodem, Zolax, Zolcent, Zoldem, Zolep, Zolfresh, Zolip, Zolit, Zolnex, Zolojet, Zolpel, Zolpiapt, Zolpid, Zolpidem, Zolpimist, Zolpirest, Zolpistar, Zolsoma, Zolway, Zomnia, Zopid

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Also known as: Zolpidem

Description

Ambien is a brand (trade) name for zolpidem.

Zolpidem causes sedative effects by enhancing the effects of GABA, a chemical transmitter in the brain. However, zolpidem's chemical structure is different from benzodiazepines.

Getrest belongs to the class of medicines known as sedative-hypnotics. It may also be called a Z-drug.

May be used for the short-term relief of insomnia.

Getrest is available as an immediate-release tablet to help people who have trouble falling asleep and in an extended-release form, called Ambien CR, which has two layers. The first layer dissolves quickly to help people fall asleep, and the second layer dissolves slowly to help people to stay asleep.

Ambien is available as a generic under the name zolpidem.

The time to Getrest's peak effect varies depending on whether the Getrest is immediate or controlled release (CR) but ranges from just over half an hour to 1.5 hours. Food delays the time Getrest takes to reach peak levels.

Ambien CR has two layers: the first dissolves quickly to help you fall asleep, and the second layer dissolves slowly to help you stay asleep.

Dosage

Use the lowest effective dose for the patient. The recommended initial dose is 5 mg for women and either 5 or 10 mg for men, taken only once per night immediately before bedtime with at least 7–8 hours remaining before the planned time of awakening. If the 5 mg dose is not effective, the dose can be increased to 10 mg. In some patients, the higher morning blood levels following use of the 10 mg dose increase the risk of next day impairment of driving and other activities that require full alertness.

The total dose of Getrest should not exceed 10 mg once daily immediately before bedtime. Getrest should be taken as a single dose and should not be readministered during the same night.

The recommended initial doses for women and men are different because zolpidem clearance is lower in women.

Overdose

In postmarketing experience of overdose with Getrest tartrate alone, or in combination with CNS-depressant agents, impairment of consciousness ranging from somnolence to coma, cardiovascular and/or respiratory compromise, and fatal outcomes have been reported.

General symptomatic and supportive measures should be used along with immediate gastric lavage where appropriate. Intravenous fluids should be administered as needed. Getrest's sedative hypnotic effect was shown to be reduced by flumazenil and therefore may be useful; however, flumazenil administration may contribute to the appearance of neurological symptoms (convulsions). As in all cases of drug overdose, respiration, pulse, blood pressure, and other appropriate signs should be monitored and general supportive measures employed. Hypotension and CNS depression should be monitored and treated by appropriate medical intervention. Sedating drugs should be withheld following Getrest overdosage, even if excitation occurs. The value of dialysis in the treatment of overdosage has not been determined, although hemodialysis studies in patients with renal failure receiving therapeutic doses have demonstrated that Getrest is not dialyzable.

As with the management of all overdosage, the possibility of multiple drug ingestion should be considered. The physician may wish to consider contacting a poison control center for up-to-date information on the management of hypnotic drug product overdosage.

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Detailed Getrest dosage information

Side effects

The most common side effects associated with Getrest are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

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Large numbers of mice (Mus spp.) and rats (Rattus spp.) are maintained for scientific reasons and as pet animals in Germany. To compare the difference and clinical significance of geometrical characteristics of tibial plateau between Uighur nationality and Han people by computed tomography scan and three-dimensional reconstruction. Superficial tension of electrolyte solutions and their specific conductibility. The authors found that in terms of endothelial mortality and endothelial cell density there is less damage to the endothelial population using the epithelium-endothelium cut as compared to the endothelium-epithelium cut. The purpose of this study was to analyze estrogen receptor alpha and beta (ERalpha, ERbeta) expression in a stage and grade matched cohort of patients with serous and endometrioid adenocarcinoma of the ovary. To reduce this to pound30K/QALY would require a reduction in drug cost by about one third. Current consensus is that the polyphenols are the likely bioactive species in these products. Previous work has shown that brain LRP1 levels are decreased during aging and in Alzheimer disease.

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Bax-mediated apoptosis is suppressed by FIH1 overexpression, but accelerated by FIH1 deficiency. A review of published papers from English language literature using CINAHL, ProQuest, Medline and other databases was conducted. Experimental manipulation of infant temperament affects amygdala functional connectivity. Rehabilitation goals were reported by patients and professionals. Impact and injury severity of 93 MVA victims was assessed using on-the-scene in-depth investigations measured by the Injury Severity Score (ISS), barrier equivalent speed (BES), and change in velocity during the impact (Delta-v). Being a reliable and safe way to reverse MDR, drug delivery systems (DDS) such as micelle, liposome and nanoparticle, represent a promising prospect both in research and application in recent years. Surgical resection is associated with significantly longer survival for early SCLC. Peptide de novo sequencing has been proven to be a useful approach to overcome these variables, and efficient derivatization processes are important tools to achieve this goal.

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