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Duphaston (Dydrogesterone)
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Duphaston

Duphaston is a synthetic progestogen and has a similar action to the female hormone, progesterone. It is used to treat menstrual disorders in women caused due to a lack of hormones. It is also used to reduce the risk of miscarriages or abortions. This medicine is not recommended for use in patients below 18 years of age.

Other names for this medication:
Climaston, Dabroston, Didrogesterona, Didrogesterone, Dirogest, Dufaston, Dydrogesteron, Dydrogesterone, Dydrogesteronum, Femaston, Femoston, Femphascyl, Gestatron, Isopregnenone

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Also known as: Dydrogesterone

Description

Generic Duphaston is an orally active progestogen which acts directly on the uterus, producing a complete secretory endometrium in an estrogen-primed uterus. At therapeutic levels, Generic Duphaston has no contraceptive effect as it does not inhibit or interfere with ovulation or the corpus luteum. Furthermore, Generic Duphaston is non-androgenic, non-estrogenic, non-corticoid, non-anabolic and is not excreted as pregnanediol. Generic name of Generic Duphaston is Dydrogesterone. Duphaston is also known as Dydrogesterone. Brand name of Generic Duphaston is Duphaston.

Dosage

The dosage schemes below are meant as general recommendations. For optimal therapeutic effect, the dosages are to be adapted to the nature and severity of the disorder. In irregular cycles due to endogenous progesterone deficiency Generic Duphaston 5 to 10 mg is recommended especially in irregular cycles due to shortened luteal phase (ie pre-menopause). Treatment should be repeated for several cycles. In secondary amenorrhoea Administration of Generic Duphaston in combination with an estrogen is usually recommended as in these conditions endogenous progesterone deficiency is nearly always accompanied by estrogen deficiency. 0,05 mg ethinylestradiol is administered each day from the 1st to the 25th day of the cycle, and 5 mg Generic Duphaston is added twice daily from the 11th to the 25th day. Five days after the subsequent withdrawal bleeding, the same is repeated to imitate a natural cycle. In dysfunctional uterine bleeding The symptomatic treatment is aimed at stopping the bleeding and including a subsequent withdrawal bleeding. To stop bleeding: Generic Duphaston 10 mg together with 0,10 mg ethinylestradiol twice daily for 5 to 7 days. To prevent heavy bleedings: Generic Duphaston 5 mg twice daily from day 11 to day 25 of the cycle, if necessary, combined with an estrogen during the first half of the cycle. In post-menopausal complaints If for the symptomatic treatment of post-menopausal complaints estrogens are used (hormone replacement therapy A?A?A? HRT), Generic Duphaston 10 mg is used to counteract the effects of unopposed estrogens on the endometrium. A subsequent withdrawal bleeding is induced. On continuous estrogen therapy: Generic Duphaston 10 mg twice daily during the first 12 to 14 days of each calendar month. On cyclic estrogen therapy: Generic Duphaston 10 mg twice daily during the last 12 to 14 days of the treatment. If you want to achieve most effective results do not stop taking Generic Duphaston suddenly.

Overdose

If you overdose Generic Duphaston and you don't feel good you should visit your doctor or health care provider immediately. Symptoms of Generic Duphaston overdosage: diarrhea, stomach pain, hot and dry skin, confusion, uneven heart rate, extreme thirst, increased urination, leg discomfort, and muscle weakness or limp feeling.

Storage

Store at room temperature below 25 degrees C (77 degrees F) away from moisture, light and heat. Throw away any unused medicine after the expiration date. Keep out of the reach of children.

Side effects

The most common side effects associated with Duphaston are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

Do not take Generic Duphaston if you are allergic to Generic Duphaston components. It is unknown how Generic Duphaston affects pregnant women or nursing mother. Do not take Generic Duphaston if you have undiagnosed vaginal bleeding or a history of thromboembolic disorders. Be careful with Generic Duphaston if you have cardiovascular, renal or hepatic impairment, diabetes mellitus, asthma, epilepsy and migraine, history of mental depression. Drug interactions can result in unwanted side effects or prevent a medicine from doing its job. Some medicines or medical conditions may interact with this medicine. Inform your doctor or pharmacist of all prescription and over-the-counter medicine that you are taking. Do not stop taking Generic Duphaston suddenly.

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Loss of LRPPRC in the liver caused a generalized growth delay, and typical histological features of mitochondrial hepatopathy. Awareness of the etiology and clinical manifestations makes it easier to suspect this condition even in the absence of a history of exposure to the insect. Voluntary induction of a premature delivery, which goes against our constant battle to reduce prematurity, represents, at this time, a paradoxical situation which is not exceptional in vasculorenal syndromes and premature rupture of the membranes. This results from a failure both to understand the leadership role and the elements necessary to carry out this role. The objective of this study was to determine the relationship between health status and productivity loss and to provide estimates of the business implications of lost work performance. We identified the first GRE in the eNOS glucophage medication classification promoter region and demonstrated that endogenous 11 beta-HSD1 and 11 beta-HSD2 play significant and distinct roles in modulating the effect of glucocorticoids on eNOS expression. An EMF cell with a nitrogen solid electrolyte--on the transference of nitrogen ions in yttria-stabilized zirconia. The present study disaggregated these two domains developmentally and examined the relation between childhood behavior trajectories and adolescent substance use.

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The result showed that the toxicity of runoff in spring was higher than those in summer. Absence of transovarial transmission of Borrelia duttonii, a tick-borne relapsing fever agent, by the vector tick Ornithodoros moubata. Acriflavine being actively bound to DNA is demonstrated not to protect DNA molecule from radiation damage. Our objective was to identify and compare available apps for ear and hearing assessments and consider the incorporation of such apps into hearing screening programs. Comparison of ICE (ifosfamide-carboplatin-etoposide) versus DHAP (cytosine arabinoside-cisplatin-dexamethasone) as salvage chemotherapy in patients with relapsed or refractory lymphoma. Nevertheless, these persons are as many in the practice of all the physicians and their various pathologies concern all the medical specialties. Bronchial asthma, a psychosomatic disease (medical psychology of the asthmatic). However, unlike in children, clinical presentation of foreign bodies in adults often varies with regard to symptoms and signs and occurs without asphyxia. In addition, diet restriction increased locomotor activity in a runwheel cage among mice of both ages but did not affect exploratory activity in a novel arena.

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The control samples were exposed to the same intensity of light generated by a conventional incandescent light bulb. At the same time, no sleep snoring children were include as controls. Together, our findings indicate that MPO-mediated methionine oxidation contributes to bacterial killing by neutrophils. This line when seen in otherwise intact corneas has been presumed to be an autoimmune endotheliopathy. Patients with solitary FVPTCs who underwent thyroid surgery were included. No embolic events occurred in the preoperative or postoperative period. A series of novel sulfone substituted 4,5-diarylthiazoles have been synthesized and evaluated for their inhibition of the two isoforms of human cyclooxygenase (COX-1 and COX-2). The C3N- anion: first detection of its electronic luminescence in rare gas solids.

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