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Coolam (Alprazolam)
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Coolam

Coolam is commonly used to treat anxiety and panic disorders. It falls into a category of medications called benzodiazepines. They are known to affect the central nervous system components and produce a calming effect, thus decreasing brain activity.

Other names for this medication:
Aldip, Alpanol, Alpaz, Alpra, Alsert, Altin, Alzopam, Alzotime, Ambulax, Anquil, Aryalam, Ateez, Besquil, Calmtec, Depoxit, Fludep, Hiprazole, Indolam, Luzarn, Mebrin, Mediprex, Nexlpra, Nokzok, Oclam, Omelam, Ozolam, Prolam, Samitol, Somnirest, Trapose, Xycalm, Zamitol

Similar Products:
Plavix, Hytrin, Ovral, Indocin, Atarax, Dramamine, Nizoral, Elavil, Aricept, Leparox, Famodic, Glatix, Menilet, Zolit, Capehope, Enalbal, Evrina,

Also known as: Alprazolam

Description

Alprazolam is used to relieve symptoms of anxiety, including anxiety caused by depression. It is also used to treat panic disorder in some patients.

Alprazolam is a benzodiazepine. Benzodiazepines belong to the group of medicines called central nervous system (CNS) depressants, which are medicines that slow down the nervous system.

This medicine is available only with your doctor's prescription.

Dosage

This section provides information on the proper use of a number of products that contain alprazolam. It may not be specific to Coolam XR. Please read with care.

Take this medicine only as directed by your doctor. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered. If too much of this medicine is used for a long time, it may become habit-forming (causing mental or physical dependence) or cause an overdose.

This medicine should come with a Medication Guide. Read and follow the instructions carefully. Ask your doctor if you have any questions.

Swallow the extended-release tablet or tablet whole with a full glass of water. Do not break, crush, or chew it.

If you are using the orally disintegrating tablet, make sure your hands are dry before you handle the tablet. Do not remove the tablets from the bottle until you are ready to take it. Place the tablet immediately on the top of your tongue. It should melt quickly and be swallowed with saliva.

If you are using the oral liquid, measure the dose with a marked measuring spoon, oral syringe, or medicine cup.

Do not eat grapefruit or drink grapefruit juice while you are using this medicine.

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

For anxiety: For oral dosage forms (solution, tablets, or orally disintegrating tablets): Adults—At first, 0.25 to 0.5 milligram (mg) 3 times a day. Your doctor may increase your dose as needed. However, the dose is usually not more than 4 mg per day. Older adults—At first, 0.25 mg 2 or 3 times a day. Your doctor may increase your dose as needed. Children—Use and dose must be determined by your doctor. For panic disorder: For oral dosage form (extended-release tablets): Adults—At first, 0.5 to 1 milligram (mg) taken in the morning once a day. Your doctor may increase your dose as needed. However, the dose is usually not more than 10 mg per day. Older adults—At first, 0.5 mg taken in the morning once a day. Your doctor may increase your dose as needed. Children—Use and dose must be determined by your doctor. For oral dosage forms (solution, tablets, or orally disintegrating tablets): Adults—At first, 0.5 milligram (mg) 3 times a day. Your doctor may increase your dose as needed. However, the dose is usually not more than 10 mg per day. Older adults—At first, 0.25 mg 2 or 3 times a day. Your doctor may increase your dose as needed. Children—Use and dose must be determined by your doctor.

Overdose

Seek emergency medical attention if you think you have used too much of this medicine. An overdose of Coolam XR can be fatal.

Overdose symptoms may include extreme drowsiness, confusion, muscle weakness, loss of balance or coordination, feeling light-headed, fainting, and coma.

Storage

Store at room temperature away from light and moisture. Do not store in the bathroom. Keep all medications away from children and pets.Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company for more details.

Side effects

The most common side effects associated with Coolam are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

Appropriate studies have not been performed on the relationship of age to the effects of alprazolam in the pediatric population. Safety and efficacy have not been established.

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Subjects were randomly assigned to one of three haloperidol plasma ranges and treated for 6 weeks. In a case report we want to demonstrate the importance of urodynamic assessment in the successful treatment of voiding difficulties after sling procedure following radical hysterectomy. The post-translational modifiers ubiquitin and small ubiquitin-related modifier (SUMO) regulate numerous critical signaling pathways and are key to controlling the cellular fate of proteins in eukaryotes. Unmanned aircraft systems as a new source of disturbance for wildlife: A systematic review. Administration of a single daily dose of liquid Orntide resulted in testosterone suppression within 6 h to levels below 0.5 ng/ml (castration level).

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An active puromycin analog derived from a non-nephrotoxic aminonucleoside. The gene frequencies were utilized for estimating the genetic distance between the breeds and breed groups. GAGs, especially heparin, are implicated in various processes, such as capacitation, acrosome reaction (AR), and sperm nuclei decondensation by interacting with a wide range of proteins, leading to fertilization. The single biggest difficulty with automated technology is the high cost of the software, making the cost of producing source plasma by this type of technology, in general, not cost efficient at this time. Decisions in force field development: an alternative to those described by Roterman et al. The effect of short-term treatment with prednisolone during proestrus and estrus on urinary estrogen excretion, estrous behavior, and ovulation in the bovine species was investigated. Notably, there was no effect on the corrected Q-wave to T-wave (QTc) interval. A stent was placed in the narrowed and dissected segment of ICA, and the dissecting aneurysm of the cavernous segment was successfully managed with a stent-assisted coil embolization. Correction of the immune response to sheep erythrocytes in mice of different strains using polyelectrolytes.

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No appreciable side effects were observed, but two patients had suppressed cortisol values and synacthen responses at six weeks. To explore the effect and toxicity profile of recombinant human interleukin 11(rhIL-11) on the platelet after hematopoietic stem cell transplantation in patients with leukemia. Lipid peroxidation dependent aldrin epoxidation in liver microsomes, hepatocytes and granulation tissue cells. Right lower lobe sleeve resection: bronchial flap to correct caliber disparity. brassicae resting spores, and nearly no complete cells were observed at 24 h treatment.

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To assess conventional, large chest tube therapy in iatrogenic pneumothorax and to determine the optimal moment when to use more invasive procedures. Cholinergic mechanisms of cutaneous active vasodilation during heat stress in cystic fibrosis. Coronary artery calcium screening in persons with metabolic syndrome and diabetes: implications for prevention. If an early diagnosis is made and appropriate treatment instituted, the prognosis is considered to be reasonably good. The A-minor I water bridge, however, does not appear to stabilize the tertiary contact, and its role is to provide structural flexibility to this binding pattern within the context of the RNA structure. We re-evaluate conclusions about disfluency production in high-functioning forms of autism spectrum disorder (HFA). Finally, reducing unit moral distress that affects learners requires formal educational opportunities to debrief about difficult end-of-life cases and formal institutional mechanisms for effective clinical ethics consultation. We evaluated the usefulness of serum IL-6 in the diagnosis of primary BDC and measured changes in serum IL-6 levels following photodynamic therapy (PDT). GDP-inhibitable proton conductance, as measured by passive swelling, was unaffected by this brief exposure to cold but more than doubled in rats kept at 4 degrees C for 10 days.

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A heterologous system for detecting eukaryotic enzymes which synthesize pseudouridine in transfer ribonucleic acids. The data from this investigation provide criteria for the rational selection of bond strength-compatible porcelains and alloys for clinical use. The cycle of the seminiferous epithelium and stages in spermatogenesis in dd-mice. Antiepileptic drug levels were not affected by nimodipine treatment but circulating nimodipine concentrations were low. The PANTHERIS score is a simple scoring system for the prediction of SAP based on easy-to-assess parameters. Involvement of the dorsal hippocampal GABA-A receptors in histamine-induced facilitation of memory in the Morris water maze. Tandem duplications of the lac region of the Escherichia coli chromosome. Enzymatic joining of the chemically synthesized segments to form a DNA duplex corresponding to the nucleotide sequence 1-26. The anti-ischemic properties of verapamil and its effect on myocardial functional potentials in coronary artery occlusion. Access to influenza vaccine in East Harlem and the Bronx during a national vaccine shortage.

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A solid and papillary neoplasm of a mesocolonic ectopic pancreas, 6 cm of diameter, was found by chance in a woman age 33 and resected surgically. Whereas the efficacy of cognitive-behavioural therapy has been demonstrated for a variety of mental disorders, there is still need for improvement, especially regarding less prevalent or more severe disorders. National Resident Matching Program statistics, and the interest in the program expressed by US graduates, have improved for the University of Arizona program during a time when national interest in family medicine has continued to decline. Anatomy in the land of Tuscany during the 15th and 16th centuries. Investigation of the urinary tract infections of schoolchildren. However, there has been no explicit analysis of the network structures formed, their dynamic behaviour nor how either impact on their ecological function. In the first group borrelidin resistance is coupled to the gene HOM3 coding for aspartokinase, in the second group to the gene LEU1. It should be noted, however, that research in this area is mostly limited to studies in small numbers of patients. Resveratrol differentially regulated the activities of SOD, catalase and GPx in paw skin as well as spinal cord of hyperalgesic rats in both phases.

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Langerhans cells are not damaged in contact allergic reactions in humans. In the duodenum, epithelial cells of villi and the neck of crypts showed positive adenosine deaminase staining whereas no staining for the enzyme was observed in the epithelial cells of the base of crypts. Then the radial plombage is placed beneath the encircling element. In the conclusion they submit a proposal of ATB prophylaxis in severe inflammations of the gallbladder and biliary pathways. Histologic analysis of macrophage and fibroblast migration, collagen regeneration, and epithelialization were significantly increased in the FN group compared with the control group. To investigate whether there is an association between vascular endothelial growth factor (VEGF) levels in serum and peritoneal fluid, and the presence of pelvic endometriosis and its clinical symptoms. This is a case report of an individually designed removable prosthesis that positions an acrylic tube through each port lateral to the pharyngeal flap, with the goal of preventing the collapse of the ports during sleep and the consequent snoring. Total lung capacity, residual volume and predicted residual volume in a densitometric study of older men. Natural killer cells actively patrol peripheral lymph nodes forming stable conjugates to eliminate MHC-mismatched targets.

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The immunomorphologic findings strongly supported the hypothesis that the replication of P. Here we describe mutations of the gene encoding ribose-binding protein that were selected as suppressors of a defect in export of that protein and that alter the folding pathway. Progressive Multifocal Leukoencephalopathy: Endemic Viruses and Lethal Brain Disease. The anthropometric (weight, height, waist and hip circumferences) and blood pressure measures were reported in some 5724 subjects. Such plants are used in traditional medicine in many countries, particularly in Africa, for skin lightening. A series of discriminant function analyses based only on clinical symptomatology suggests that psychotic and neurotic depressives do not differ globally but at a fairly specific level and that the principal, if not only, clinical difference between the groups is one of severity. Antiinflammatory drugs and gastrointestinal bleeding: a comparison of aspirin and ibuprofen. Seven-locus (rs699947, rs833061, rs1570360, rs2010963, rs25648, rs833068 and rs833070) haplotype analysis demonstrated positive association of ATGCCAA, ACAGCAG and CCAGCGG, and negative association of CCAGCAA and ATGCCGG haplotypes with PE, all of which except for ACAGCAG remained associated with PE after correcting for multiple comparisons.

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The regular use of pain assessment tools and adequate training of all healthcare professionals are essential requirements for an effective pain control. In MLP, AII significantly increased plasma LH (p less than 0.02 vs. Only three patients lost 30 degrees or more of flexion of the elbow or of pronation or supination of the forearm. Ultrasonographic findings in circumscribed choroidal hemangioma after photodynamic therapy. The main objective of this study was to understand the experiences of women with disabilities who are or have been abused by their partners and to explore the knowledge, views and training requirements of primary care professionals. Human perception of horizontal trunk and head rotation in space during vestibular and neck stimulation. Sirtuin 6 plays an oncogenic role and induces cell autophagy in esophageal cancer cells. The peptide was coupled to cellulose and used to absorb mid-region antibodies from a goat antiserum against intact human PTH. Reactive oxygen species (ROS) promote formation of AGEs, which cause AGE-receptor-mediated ROS generation with activation of signalling pathways leading to tissue injury and further AGE accumulation. The stereochemical assignments and overall structures were confirmed by subsequent total synthesis of depsipeptide 1, as reported in the accompanying contribution.

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Changes in pressure gradient after VSS were classified according to pattern of gradient resolution into types I-III. This residual basal lamina formed the pathway for the orderly regeneration of microvessels. Discovery of a high-energy gamma-ray-emitting persistent microquasar. A study has been made with intracellular electrodes of the responses of acini of the salivary gland of Nauphoeta cinerea Olivier to salivary duct nerve stimulation. Incident STIs were defined as cases of gonorrhea, chlamydia, or early syphilis acquired after HIV diagnosis. As will be shown, this scenario results in the highest values of adhesion force and interaction energy. Thrombolysis of prosthetic tricuspid valve thrombosis with human recombinant tissue plasminogen activator in an adolescent. Antisense RNA to eIF4E suppresses oncogenic properties of a head and neck squamous cell carcinoma cell line. This report includes data from 922 adult native renal biopsies in patients referred from the whole country and performed in our center from 1996 till February 2012. These results suggest that the glutathione status of macrophages in the artery wall could be important in both controlling foam-cell formation and the detoxification of oxidized LDL.

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Peritubular cells that display a flat-stellate shape transition when placed in culture medium free of serum (with or without hormones and growth factors), accumulate various proteins in the medium that are less apparent when these cells are maintained in medium supplemented with serum. Photodegradation of polychlorinated dibenzo-p-dioxins and dibenzofurans in aqueous solutions and in organic solvents. Blood space volumes and plasma diffusion distances had negligible effects on diffusing capacity. The color dissimilarity on the cosmetically sensitive regions frequently induces quality of life impairment and high willingness to pay for treatment in patients with vitiligo. Cyclosporin A treatment caused only minor histopathologic changes in SHRs receiving a low-sodium diet. Because of the local occurrence of Hb variants and the ethnic origin of a given population, every individual laboratory must establish and validate its own assay method. These analyses could shed some light on the biological mechanisms involved in the adaptation and survival of this yeast in the sugarcane fermentation process for ethanol production. Suppressing TSG101 by siRNA in ovarian cancer cells led to growth inhibition, cell cycle arrest, and apoptosis with concurrent increases in p21 mRNA and protein.

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The value of potency testing of poliomyelitis and measles vaccines as an integral part of cold chain surveillance. However, while fertilization increased the relative abundance of fungi, warming caused only a minimal shift in the microbial community composition based on the phospholipid fatty acid (PLFA) and neutral lipid fatty acid (NLFA) profiles. consolidation of fractures or of non-union and congenital pseudarthrosis, beneficial effects in urinary incontinence or in neuropathology. The Biotes conversion prosthesis: a provisional fixed prosthesis supported by osseointegrated titanium fixtures for restoration of the edentulous jaw. Local physicians chose nephrectomy with or without preoperative chemotherapy as the initial treatment based on the risk of unsafe and/or incomplete immediate surgery. HCV antigens were detected by immunoblot analysis, using heparin-purified brain samples, and HCV immunoreactivity was detected in astrocytes and in macrophage-microglial cells. A variety of patient characteristics, including many not directly related to LRI, were consistently associated with long-term mortality in two cohorts with differing illness severity. One is the transcription factor Osf2/Cbfa1, which allows mesenchymal stem cells to differentiate into osteoblasts. The average elimination half-life (T1/2) of ticarcillin increased from 0.95 h in patients with plavix generic creatinine clearance (Clcr) of 80 ml/min to 1.8, 4.4, 6.9 and 11.2 h respectively in mild, moderate and severe renal insufficiency and in almost anuric patients. Those phases reviewed include ovulation, fertilization and tubal passage of sperm and fertilized ova, capacitation of spermatozoa, the spacing of ova along the uterus, preimplantation stages of the uterus and uterus-blastocyst interaction, decidualization, the zona pellucida, normal and delayed nidation, superfetation, and the parthogenetic activation of eggs.

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The system incorporates LED digital displays, a bargraph and audiovisual alarms. The self-sustained turbulence that develops in magnetized accretion disks is suppressed in the weakly ionized, quiescent disks of close binary stars. Prokaryotic expression and purification of SRG4, a novel mouse spermatogenesis gene. Fresh heparinized whole blood was incubated with ABO-compatible or -incompatible RBCs. Glucose bactrim ds dose uses was also reduced, but not dose-dependently and only to a moderate extent. Fluorescent cells were observed in the wall of a restricted part of the branchio-cardiac veins which was electrophysiologically shown to be a chemoreceptor region. Professional-led cancer support groups can improve quality of life and address unmet needs, but most Canadians affected by cancer do not have access to or do not make use of cancer support groups. Vascular endothelial cells (EC) are one of the initial cells exposed to decreases in blood oxygen tension. Intravascular coagulation associated with the adult respiratory distress syndrome.

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High sulfur loading cathodes fabricated using peapodlike, large pore volume mesoporous carbon for lithium-sulfur battery. To conduct an initial investigation of the psychometric properties of the Hopkins Rehabilitation Engagement Rating Scale (HRERS), a 5-item, clinician-rated measure developed to quantify engagement in acute rehabilitation services. A green, rapid and cost effective method for the bio-synthesis of silver nanoparticles (AgNPs), using polyphenols present in European cranberry bush fruit extracts was developed. The high dose of curcumin not only enhanced G2/M cell cycle arrest, but also induced S phase of cell cycle arrest. A historical overview of key elements in the evolution of quality improvement in nursing is presented. Calculated lifetimes are discussed in terms of energy transfer from primarily excited to fluorescent chromophores.

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In order to judge the QoL of OCD patients, obsessions and compulsions have to be considered differently. Severe methemoglobinemia from topical anesthetic spray: case report, discussion and qualitative systematic review. The results obtained showed a significant age-related decrease in pDC numbers, whilst cDC numbers remained unaltered. The cell lines which show only moderate decreases in enzyme activity and polyamines differentiate poorly while the cell lines which fail to respond to DFMO in that polyamines do not drop below the threshold level necessary to induce differentiation fail to differentiate. The potential advantages which Chinese learners may have in learning from the global dental curriculum are proposed. Immunophenotyping clearly indicated a lymphoid origin of the blasts and showed positivity of HLA-DR, CD10, CD19 and CD24 markers. Here, we develop a simple model to mechanistically explain the emergence of periodic changes in length and spatiotemporal dynamics of traction forces measured in chemotaxing unicellular amoeba, Dictyostelium discoideum. The magnitude of F1, F2, vowel space area, and duration differences for vowels in content and function words was not statistically different for speakers with ALS and healthy controls. To test the hypothesis that the antiproliferative effect of heparin in vivo may be related to an inhibition of proto-oncogene expression, the effects of pretreatment with heparin on the expression of the c-myc, c-fos and c-jun proto-oncogenes were examined in a rabbit model of balloon denudation. No significant level of differentiation was evident between the two Libyan Tuareg groups according to AMOVA.

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The underestimation rate of ultrasound-detected non-mass lesion was significantly lower with VAB than with CCNB. This connection, and the comparable molecular weights of the coat proteins of Golgi-derived and clathrin-coated vesicles, indicates that they may be structurally related. Prokaryotic Contig Annotation Pipeline Server: Web Application for a Prokaryotic Genome Annotation Pipeline Based on the Shiny App Package. This suggests that the resulting phenotypic transformation in sp-FGF-1 transfectants requires an uninterrupted interaction between the FGF-1 ligand and its receptor. These results support the existence of two functionally different human BCGF species, differing at least in their relative sugar content and distinct from IL 2.

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Pulmonary arterial occlusion pressure (Ppao) may not accurately reflect left ventricular filling pressure (LVFP) during ventilation with positive end-expiratory pressure (PEEP) because increases in pleural pressure (Ppl) increase measured intrathoracic vascular and cardiac chamber pressures relative to atmospheric while decreasing LVFP by decreasing venous return. It seems that the combination of portal resistance and portal hyperdynamics are the necessary pathogenic factor of formation of portal hypertension. Chorions of unfertilized and fertilized eggs of the rainbow trout were isolated from tissue and yolk components and investigated for isopeptide bonds. Golgi-endomannosidase provides an alternate glucosidase-independent pathway of glucose trimming. Most of blood glucocorticoids are bound to corticosteroid-binding globulin (CBG), which liver expression and circulating levels are higher in females than celebrex medication typical dose in males. The avidity of the detected antibodies appeared variable and was quite low in some of them. However, the protein amount of heat shock protein 70, which is a molecular chaperon and a marker of injury, showed no significant changes. Preliminary study of the effects of feeding ethyl mercury chloride on four breeds of chickens.

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The application of these methods is illustrated by some results of appropriate investigations in urban areas. Improvements in mixing operations of water treatment plants by use of a stable finite element model. The role of mechanical support and transplantation in treatment of patients with end-stage cardiomyopathy. Other host cell types may be important in natural resistance, fungal spores being handled by the macrophages which, under conditions when animals are not immunosuppressed, are likely to be an effective first line of defense. The range of positive benefits experienced by women suggests a running/walking program can help fill a gap in care for women diagnosed with breast cancer, and thus be part of cancer rehabilitation. The key statistical features of this process are a shift of the mean population refraction toward emmetropia and a reduction in variability.

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Delayed catabolism of apoB-48 lipoproteins trileptal medication drug class due to decreased heparan sulfate proteoglycan production in diabetic mice. Outcome status was determined from medical records and telephone interviews. These results suggest that fresh vascularized grafts in the judiciously matched or immunosuppressed recipient offer attractive clinical possibilities. In vivo inhibition of low density lipoprotein receptor-related protein improves survival of factor VIII in the absence of von Willebrand factor. The same combination administered for 10 days following SE in 3-week-old rats, reduced the development of spontaneous recurrent seizures and limited the extent of mossy fiber sprouting. Clinico-bacteriological characteristics of postvaccinal lymphadenitis in the calcinosis phase.

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