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Asacol (Mesalamine)

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Asacol is used to treat and prevent mild to moderately active ulcerative colitis (an inflammatory bowel disease). It works inside the bowels to reduce inflammation and other symptoms of the disease.

Other names for this medication:
Canasa, Mesacol, Mesalamine, Pentasa, Rowasa, Tidocol, Walasa

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Also known as: Mesalamine


Aspirin may also be used to lessen the chance of heart attack, stroke, or other problems that may occur when a blood vessel is blocked by blood clots. Aspirin helps prevent dangerous blood clots from forming. However, this effect of aspirin may increase the chance of serious bleeding in some people. Therefore, aspirin should be used for this purpose only when your doctor decides, after studying your medical condition and history, that the danger of blood clots is greater than the risk of bleeding. Do not take aspirin to prevent blood clots or a heart attack unless it has been ordered by your doctor.

Salicylates may also be used for other conditions as determined by your doctor.

The caffeine present in some of these products may provide additional relief of headache pain or faster pain relief.

Some salicylates are available only with your medical doctor's or dentist's prescription. Others are available without a prescription; however, your medical doctor or dentist may have special instructions on the proper dose of these medicines for your medical condition.


This section provides information on the proper use of a number of products that contain mesalamine. It may not be specific to Asacol 800. Please read with care.

Take this medicine exactly as directed by your doctor. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered. Do not stop using this medicine without checking first with your doctor.

Keep using this medicine for the full time of treatment, even if you begin to feel better after a few days. Do not miss any doses.

Swallow the capsule or tablet whole. Do not open, break, crush, or chew it.

If you are taking the Asacol® delayed-release tablet:

You may take this medicine with or without food. Drink extra fluids so you will urinate more often and help prevent kidney problems (eg, kidney stones).

Take the Asacol® HD tablet on an empty stomach, at least 1 hour before or 2 hours after a meal.

You should take the Lialda® tablets with food. All other brands of capsules and tablets can be taken with or without food.

If you have trouble swallowing the Delzicol® capsule, carefully open the capsule and take out the 4 tablets. Swallow the tablets whole and make sure all 4 are taken at the same time as one dose. Do not cut, break, crush, or chew them.

The contents of the Pentasa® capsule may be sprinkled onto soft foods (eg, applesauce or yogurt) if you have trouble swallowing the capsule. The mixture must be swallowed right away without chewing.

If you are taking the delayed-release capsule, extended-release capsule, or delayed-release tablet, part of the capsule or tablet may pass into your stool after your body has absorbed the medicine. Contact your doctor if this happens more often than 1 or 2 times.

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

For the treatment of ulcerative colitis: For long-acting oral dosage form (delayed-release capsules): Adults—800 milligrams (mg) 3 times a day. Children 5 years of age and older—Dose is based on body weight and must be determined by your doctor. The dose is usually not more than 2400 mg per day, divided in 2 doses. Children younger than 5 years of age—Use and dose must be determined by your doctor. For long-acting oral dosage form (delayed-release tablets): Asacol®: Adults—800 milligrams (mg) (two 400 mg tablets) 3 times a day for 6 weeks. Children 5 years of age and older—Dose is based on body weight and must be determined by your doctor: Weighing 54 to 90 kilograms (kg)—1200 mg (three 400 mg tablets) in the morning, then 1200 mg (three 400 mg tablets) in the afternoon for 6 weeks. Weighing 33 to less than 54 kg—1200 mg (three 400 mg tablets) in the morning, then 800 mg (two 400 mg tablets) in the afternoon for 6 weeks. Weighing 17 to less than 33 kg—800 mg (two 400 mg tablets) in the morning, then 400 mg (1 tablet) in the afternoon for 6 weeks. Children younger than 5 years of age or weighing less than 17 kg—Use and dose must be determined by your doctor. Asacol® HD: Adults—1600 milligrams (mg) 3 times a day for 6 weeks. Children—Use and dose must be determined by your doctor. Lialda®: Adults—2.4 to 4.8 grams (g) once a day. Children 5 years of age and older—Dose is based on body weight and must be determined by your doctor: Weighing more than 50 kilograms (kg)—4.8 grams (g) once a day for 8 weeks. Then 2.4 g once a day. Weighing more than 35 to 50 kg—3.6 g once a day for 8 weeks. Then 2.4 g once a day. Weighing 24 to 35 kg—2.4 g once a day for 8 weeks. Then 1.2 g once a day. Children younger than 5 years of age or weighing less than 24 kg—Use and dose must be determined by your doctor. For long-acting oral dosage form (extended-release capsules): Adults— For Apriso®: 1.5 grams (g) (four capsules) once a day as a single dose in the morning. For Pentasa®: 1 g (four 250 milligrams [mg] capsules or two 500 mg capsules) 4 times a day. Children—Use and dose must be determined by your doctor. For prevention of ulcerative colitis: For long-acting oral dosage form (delayed-release capsules): Adults—1600 milligrams (mg) per day, taken in divided doses. Children—Use and dose must be determined by your doctor. For long-acting oral dosage form (Asacol® delayed-release tablets): Adults—1600 milligrams (mg) (four 400 mg tablets) per day, taken in 2 to 4 divided doses. Children—Use and dose must be determined by your doctor. For long-acting oral dosage form (Lialda® delayed-release tablets): Adults—2.4 grams (g) once a day. Children—Use and dose must be determined by your doctor.


Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.


Keep out of the reach of children.

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Do not keep outdated medicine or medicine no longer needed.

Side effects

The most common side effects associated with Asacol are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


You should not use Asacol HD if you are allergic to mesalamine, aspirin, sulfasalazine, or salicylates (such as Disalcid, Doans Pills, Dolobid, Kaopectate, Nuprin Backache, Pepto-Bismol, Tricosal, Trilisate, and others).

To make sure Asacol HD is safe for you, tell your doctor if you have ever had:

a kidney stone or kidney disease; liver disease; a blockage in your stomach or intestines (such as pyloric stenosis); or a skin condition such as eczema.

Tell your doctor if you are pregnant or plan to become pregnant. It is not known whether mesalamine will harm an unborn baby. However, having untreated or uncontrolled ulcerative colitis during pregnancy may cause complications such as low birth weight or premature birth. The benefit of treating ulcerative colitis may outweigh any risks to the baby.

It may not be safe to breastfeed while using this medicine. Ask your doctor about any risk. If you are breastfeeding, tell your doctor if you notice diarrhea in the nursing baby.

Do not give this medicine to a child. Asacol HD is not approved for use in anyone younger than 18 years old.

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The average cumulative risks of breast and ovarian cancer for carriers of mutations in BRCA1 and BRCA2 attending genetic counseling units in Spain. Inhibition of angiogenesis by a tenascin-c peptide which is capable of activating beta1-integrins. Withdrawal of salt supplementation from adrenalectomized Wistar rats distinguishes between those animals with, and those without, adrenocortical insufficiency. Early subclinical atherosclerosis in women with previous gestational diabetes mellitus. The use of video as a pedagogic tool for the training of perioperative nurses: a literature review. Both, experienced and novel subjects proved to be able to deliver mental commands with high accuracy and speed. Discrete potentials are present in the great arteries of a select group of patients with outflow tract ventricular tachycardia originating above the semilunar valves. We review the biology of Mhc genes with particular reference to their relevance to avian mating and social systems.

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Nitrogen sources for renal ammoniagenesis: study with 15N amino acid. The organ chamber technique was employed to study rabbit renal artery rings. The functions of the DEG lists determined by IPA were compared across the four different platforms and two test sites for Affymetrix platform. EGFR activation appears to be effective in reducing the time of reepithelialization after corneal wound healing, with potential uses in penetrating keratoplasty, refractive surgery, alkali burns, diabetic keratopathy, keratopathy following chemotherapy, cornea transplantation, and dry eye. The strongest predictor of survival-the number of metastases present at the diagnosis of stage IV disease-represents a variable to consider in future staging systems. Isolated involvement of the thyroid by tuberculosis is very rare as reported in literature. Pulmonary infections associated with non-tuberculous mycobacteria in immunocompetent patients. Failure to demonstrate Borna disease virus genome in peripheral blood mononuclear cells from psychiatric patients in Korea.

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Analysis of the fucose and sialic acid in mucoid sputum from patients with chronic obstructive pulmonary disease. Images were acquired using an iMScope at a mass-to-charge range of 100-1000. Increasing level of asthma control was related to improved HRQoL and lower costs. Ubiquitin-independent binding of Hrs mediates endosomal sorting of the interleukin-2 aceon 4 mg receptor beta-chain. It is suggested that beta-adrenoceptor is involved in the control of cell proliferation, but its role in the pathogenesis of esophageal cancer remains unknown. Local recirculation of injected (3H)testosterone from the testis to the epididymal fat pad and the corpus epididymidis in the rat. The sequential polypeptides (L-Arg-Xaa-Gly)n where Xaa represents amino acid residues Ala, Val and Leu, were employed as models of arginine-rich histones, in studying their interactions with nucleic acids. Comparison of aldehyde fuchsin staining, metachromasia and periodic acid-Schiff reactivity of various tissues.

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