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Amitryptyline (Amitriptyline)

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Amitryptyline works by affecting the balance of certain chemicals in the brain. It helps improve mood, relieve anxiety and tension, helps you sleep better, and increase your energy level. Amitryptyline is readily absorbed and starts action within approximately 6 hours of taking it orally.

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Also known as: Amitriptyline


Amitryptyline (amitriptyline) is a tricyclic antidepressant with sedative effects. Amitriptyline affects certain chemical messengers (neurotransmitters) that communicate between brain cells and help regulate mood.

Amitryptyline is a prescription medicine used to treat symptoms of depression.


Usual Adult Dose for Depression:

OUTPATIENTS: -Initial dose: 75 mg orally per day in divided doses; this may be increased to 150 mg/day (if needed) -Maintenance dose: 40 to 100 mg orally per day -Maximum dose: 150 mg/day Alternate outpatient treatment regimen: 50 to 100 mg orally as a single dose at bedtime; this may be increased by 25 or 50 mg as needed at bedtime to a total of 150 mg/day INPATIENTS: -Initial dose: 100 mg orally per day -Maintenance dose: 40 to 100 mg orally as a single dose at bedtime -Maximum dose: 300 mg/day Comments: -Dose increases should preferably be made in the late afternoon or at bedtime due to the sedative effect. -The full therapeutic effect may take as long as 30 days to develop. -Maintenance doses should be reduced to the lowest amount that will maintain relief of symptoms when satisfactory improvement has been obtained. -Maintenance therapy should be continued for 3 months or longer to lessen the possibility of relapse. Use: Relief of symptoms of depression

Usual Geriatric Dose for Depression:

10 mg orally 3 times a day AND 20 mg orally once a day at bedtime Comments: -The full therapeutic effect may take as long as 30 days to develop. -Elderly patients should be monitored carefully and serum levels obtained as clinically appropriate. -Dose adjustments should be made according to clinical response. Use: Relief of symptoms of depression

Usual Pediatric Dose for Depression:

12 years or older: 10 mg orally 3 times a day AND 20 mg orally once a day at bedtime Comments: -The full therapeutic effect may take as long as 30 days to develop. -Dose adjustments should be made according to clinical response. Use: Relief of symptoms of depression

Detailed Amitryptyline dosage information


If you overdose Amitryptyline and you don't feel good you should visit your doctor or health care provider immediately. Symptoms of Amitryptyline overdosage: seizures, loss of consciousness for a period of time, seeing things or hearing voices that do not exist, agitation, feeling drowsy, rigid muscles, vomiting, high temperature, cold body temperature, problems concentrating, abnormal heartbeats, confusion.


Store at room temperature between 20 and 25 degrees C (68 and 77 degrees F) away from moisture and heat. Throw away any unused medicine after the expiration date. Keep out of the reach of children.

Side effects

The most common side effects associated with Amitryptyline are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


You should not use Amitryptyline if you are allergic to amitriptyline, or:

if you have recently had a heart attack.

Do not use Amitryptyline if you have used an MAO inhibitor in the past 14 days. A dangerous drug interaction could occur. MAO inhibitors include isocarboxazid, linezolid, methylene blue injection, phenelzine, rasagiline, selegiline, tranylcypromine, and others.

Tell your doctor if you have used an "SSRI" antidepressant in the past 5 weeks, such as citalopram, escitalopram, fluoxetine (Prozac), fluvoxamine, paroxetine, sertraline (Zoloft), trazodone, or vilazodone.

To make sure Amitryptyline is safe for you, tell your doctor if you have ever had:

bipolar disorder (manic-depression) or schizophrenia; mental illness or psychosis; liver disease; heart disease; a heart attack, stroke, or seizures; diabetes (amitriptyline may raise or lower blood sugar); glaucoma; or problems with urination.

Some young people have thoughts about suicide when first taking an antidepressant. Your doctor should check your progress at regular visits. Your family or other caregivers should also be alert to changes in your mood or symptoms.

Tell your doctor if you are pregnant or breastfeeding.

Amitryptyline is not approved for use by anyone younger than 12 years old.

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Thoughts on public policy to increase family-based care and decrease institutional care. Here, we pharmacokinetically analyzed (125)I-labeled PNA(TAR) conjugated with two CPPs: a 16-mer penetratin derived from antennapedia and a 13-mer Tat peptide derived from HIV-1 Tat. Comparison of cannabinoid pharmacokinetic properties in occasional and heavy users smoking a marijuana or placebo joint. Plasma somatomedin C/insulin-like growth factor I in liver diseases. In case of PPHN, favorizing factors such as acidosis, stress, lung over distension, and polyglobuly should be treated. Intensity of bitterness (scalar dimensions) of PTC is a separate trait having no commonality with the genetic basis of recognition threshold for PTC tasting ability. Moreover, through an emphasis on costs and benefits, the overseers of prevention policy will be better placed to consider the relative efficiency of existing policies--since all share the common objective of reducing future morbidity and mortality.

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The results of the current study indicate that telomerase is highly activated in biliary tract carcinomas and that the detection of a telomerase ladder in biopsy samples is an excellent tool for the diagnosis of bile duct carcinomas. Characterization of particle-associated choriomammotrophin and progesterone in ovine placentomes. The chronically ill, developmentally disabled, mentally ill and aging population has looked to long-term care support services as a means of physical and emotional support. There was no significant difference in menstrual blood loss (MBL) between those women treated with the OCP and danazol, mefenamic acid or naproxen. To establish the existence of concurrent infections by different dengue virus (DENV) serotypes in an outbreak in the Northwestern in Peru during 2008. Using a simple glucuronidase assay protocol, drug efficacy tests yielded results similar to those from cell counting. Lacey and Lacey hypothesize the presence of cortical inhibitory influences which result from the cardiac events which initiate baroreceptor discharge.

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To identify and characterize food items with high risk of airway obstruction in children younger than 15 years. Osteoclast-gene expression profiling reveals osteoclast-derived CCR2 chemokines promoting myeloma cell migration. The organotypic culture system allows for the examination of neuronal, astrocytic and microglial effects, but as an ex vivo preparation, does not address effects of blood flow, or recruitment of peripheral inflammatory cells. Along with procedural factors, individual susceptibility to these events plays an important role. HuLuc63-mediated antimyeloma activity was tested in vitro in antibody-dependent cellular cytotoxicity (ADCC) assays and in vivo using the human OPM2 xenograft model in mice. Commonly identified bacterial and viral pathogens such as Pseudomonas spp., Corynebacterium diphtheriae, Escherichia coli, Staphylococcus spp., and respiratory synctial virus (RSV) were inoculated into either gauzes or diapers, and their survivals were characterized. Temporal-mediated FGFR1 independence: implications for targeting candidate molecules in prostate cancer. The most important methods to determine the cohesive interactions of materials and adhesive interactions between different substances are reviewed. Together, these data show that Vif mediates the degradation of Vpr and modulates Vpr-induced G2 arrest in HIV-1-infected T-cells. A 61-year-old man presented to the emergency room with significant weight loss.

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The records of 610 patients with pathologic stage I complete pulmonary resection were retrospectively reviewed. Thus far, genetic analysis has identified mutations in eleven different genes but it is clear that additional phenotypic subgroups exist where the underlying genetics has not yet been defined. Antibodies are very often used as specific cell and/or tissue markers. When the task was performed under ganzfeld viewing (alternating wavelengths) so that the LGN would output only the difference between the two wavelengths, discrimination was poor and sometimes, absent. In situ complex adenocarcinoma on the femoral part of the hindlimb in an Asian Leaf Turtle (Cyclemys dentata). An increasing body of circumstantial evidence implicates a role of TLR signalling in systemic lupus erythematosus (SLE), atherosclerosis, asthma, type 1 diabetes, multiple sclerosis, bowl inflammation and rheumatoid arthritis (RA). Elephant numbers (density), study duration, rainfall, tree cover, and the presence of artificial water and fences failed to describe patterns of impact.

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However, project implementation was incomplete: first because it did not cover all intended geographic areas, and second because of a recurring inconsistency in the supply and distribution of the fish. This study suggests the need for enforcement of laws restraining roaming or straying dogs and proper veterinary care of dogs. In vivo imaging of sentinel nodes using fluorescent silica nanoparticles in living mice. Intensive pharmacovigilance was carried out in departments of internal medicine of two university hospitals. CT scan, MR imaging and anatomopathologic correlation in the glottic carcinoma T1-T2. We advocate the use of the presented method rather than employing less advanced approaches for curve comparison. Gender and parenthood did not contribute to knowledge, but the field of expertise did. The binary or ternary combinations characterized by the highest coupling constants and the highest intensities are those involving the nu(OH), delta(OH), gamma(OH), and nu(C-O) vibrations.

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Pseudohypoaldosteronism types I and II: little more than a name in common. Trait variation and genetic diversity in a banana genomic selection training population. Case of profuse ulcer hemorrhage in patients with subarachnoid hemorrhage. Increased vascular reactivity to ET-1 and altered protein levels of ETA and ETB receptors could play a role in the pathogenesis of cardiovascular complications associated with chronic ethanol consumption. Right thoracophrenotomy in simultaneous treatment of hepatopleuropulmonary hydatid cysts. Sensitivity to perspective structure while walking without vision. Evaluation of bladder neoplasms cases followed-up at the radioinstitute O. The deubiquitinylation and localization of PTEN are regulated by a HAUSP-PML network. SDS gel electrophoresis of microtubule proteins obtained from bovine brain by polymerization cycles revealed a new protein of 18 kDa. The results showed that the survival time of mice in the 500 mg Chinese herbs group and sulfadiazine group was significantly longer than that of the PBS control group.

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Nature and extent of brain lesions in mice related to ingestion of monosodium glutamate. There are no national level data on types of dialysis in use for acute kidney injury (AKI). Helicopter Transport From the Scene of Injury: Are There Improved Outcomes for Pediatric Trauma Patients?. Since genetic testing for the premutation is resource intensive, it is not practical to screen individuals for FX premutation status using genetic testing. The response was associated with induction of the yeast caspase, Yca1p, and was abolished in a yca1Delta mutant. When a cooling rate of 0.5 degree C/min is used, renal function is significantly reduced whether the final temperature is -10, -15, or -20 degrees C. Two authors assessed articles for inclusion in the review and extracted data.

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There are 2 morphologically distinct types of inclusions with different mechanisms of formation and diagnostic significance, including bona fide nuclear inclusions and nuclear pseudoinclusions. Our secondary outcomes were all-cause mortality, ascites, variceal bleeding, hepato-renal syndrome, hepatic encephalopathy, hepatocellular carcinoma, non-serious adverse events (each reported separately), and sustained virological response. 6) Anti-immune mechanisms: these allow parasites to resist innate humoral factors, to neutralize host antibodies or to scavenge reactive oxygen species within macrophages. Trapezoid chest compressions and active decompression to zero level improved blood flow to the brain. The potential of suppressing BMP inhibitors is emerging as a biological therapeutic target in bone tissue engineering, because it results in an unopposed synergy between the various growth factors that are involved in osteogenesis, within their physiological milieu. Here we report a systematic study to examine the effects of surface coating chemistry on the hydrodynamic size, fluorescence quantum yield, photostability, chemical stability, and biocompatibility of water-soluble QDs. Surveys were mailed to 250 randomly selected households within 500m of 12 matched parks. In contrast, no significant difference was seen between WHO grade-II and -III oligodendrogliomas.

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Above and beyond the effects of age and gender, significant relationships were found between general cognitive ability (IQ) and the volume of subcortical brain structures (cerebellum and caudate) as well as spatial working memory and the putamen. Computational study on nonenzymatic peptide bond cleavage at asparagine and aspartic acid. Human glutathione transferase A1-1 (GST A1-1) is a detoxifying enzyme catalyzing the conjugation of glutathione with a variety of hydrophobic, electrophilic substrates. Correlation between sealer penetration and microleakage following the use of MTAD as a final irrigant. Examining intra-rater and inter-rater response agreement: a medical chart abstraction study of a community-based asthma care program. In the animal exposed to dehydrating conditions a statistically highly significant reduction in prolactin binding to the membranes from the kidney and epidermis was recorded. After a delay following symmetrical phosphatidylinositol (3,4,5)-triphosphate (PIP(3)) production, a polarized distribution of PIP(3) was induced by positive feedback requiring actin polymerization. Bias against foreign-born or foreign-trained doctors: experimental evidence. Reactive oxygen species (ROS) are important mediators of a variety of pathological processes, including inflammation and ischemic injury. We used another technique, that is, radiofrequency ablation (RFA), for treatment of a sporadic AML in a patient with a solitary kidney, in whom maximal sparing of normal renal tissue was required.

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A comparison with caudal block for intra and postoperative analgesia. Use of a mix of strategies, including social distancing, antiviral medications, and targeted vaccination, may limit the overall attack rate so that demand for care would not exceed the capacity of the infrastructure. Difference in tree growth responses to climate at the upper treeline: Qilian Juniper in the Anyemaqen Mountains. Manganese-Based Layered Double Hydroxide Nanoparticles as a T1 -MRI Contrast Agent with Ultrasensitive pH Response and High Relaxivity. The second an 11-year-old boy who presented with a mass lesion on the left thalamic and basal ganglionic region, diagnosed as germinoma. Production of mycotoxins by Penicillium expansum inoculated into apples. The circulating levels of melatonin in this species exhibited daily variations with a decrease during the photophase (0600, 1200, and 1800 h) and an increase during the scotophase (0000 h), while cortisol levels peaked during the early photophase (0600 h). The effect of glucose on urinary cation excretion during chronic extracellular volume expansion in normal man.

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Left ventricular diastolic mechanical dyssynchrony is common in pediatric DCM, especially in patients who subsequently experience transplantation or death, and may be associated with a decreased length of transplantation-free survival. Further study demonstrated that K6PC-9p inhibited ConA-induced IL-4 secretion and LPS-induced macrophage activation. scapularis burdens on white-footed mice (Peromyscus leucopus) and eastern chipmunks (Tamias striatus) to explore which factors are important to predicting tick burdens. Measurement by film-dosimeter of the local radiation load in medical x-ray departments. Although the data collected over the years give an idea of what happens during the larval development of T. It is well established that sexually dimorphic neural regions are organized by steroid hormones during development. This study indicates that thromboembolism is a common complication in the acute phase of Takotsubo cardiomyopathy, and anticoagulation therapy should be performed in all patients until wall motion abnormalities improve. The aims of this study were to report the surgical and visual outcomes of posterior polar cataract and to assess the risk factors for posterior capsule rupture. After treatment of spermatogonia, 9 enzyme-activity mutants in 4247 F1 offspring of males treated with 80 mg ENU/kg body weight, 15 mutants in 3396 F1 offspring of a 160-mg/kg group, and 9 mutants in 1402 F1 offspring of a 250-mg/kg group were detected. Identification of the equine rhinopneumonitis virus isolated from aborted lioresal 25 mg fetuses.

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The first peak is caused by systemic inflammatory response syndrome (SIRS), which takes place in the first week of the disease. The goals of this case study were to identify the policy influences on trail development, explore the roles of key players in trail development, and compare and contrast findings from the different trails. Coronary flow velocity reserve and aortic distensibility indices in hypertensive patients with hypercholesterolaemia and normal epicardial coronary arteries. Transporter engineering for cellobiose fermentation under lower pH conditions by engineered Saccharomyces cerevisiae. Simple aneurysmectomy without mitral valvuloplasty was sufficient to relieve significant mitral regurgitation in this case. Factor analysis of the adolescent version of the Eating Disorders Examination Questionnaire (EDE-Q): results from Swedish general population and clinical samples. Furthermore, it unravels a parkin-Pink-1 feedback loop controlling mitochondrial physiology that could be disrupted in neurodegenerative conditions. Web-based approaches, specifically social media sites, represent a promising approach for recruiting young gay and bisexual men for research studies. Enzyme-substrate complexes of diphosphopyridine nucleotide-linked aldehyde dehydrogenase of yeast.

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Even so, responses in protected communities diverged from exploited communities. MicroRNAs (miRNAs) are a class of non-protein coding small RNAs that regulate expression of genes at post-transcriptional levels. Since the TP activity proved to be related to PD-ECGF expression and angiogenesis, we can state that TP seems to be an active form of PD-ECGF growth factor in endometrial carcinoma. Pathological aspects of bronchopulmonary cancers (structures and course). Available evidence suggests that the community strategy with the greatest impact on neonatal mortality is home visits by CHWs combined with community mobilization. Based on preclinical findings, it is hypothesized that NMDA receptors mediate the common adaptive processes that are involved in the development, maintenance, and expression of nicotine addiction.

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Studies of proteinuria after exertion in a group of young athletes. Drought stress adversely affects plant growth, development, and productivity. In recent years there has been a rapid growth in patient monitoring and medical data analysis using a number of computer-aided systems based on expert systems, fuzzy logic and many other intelligent techniques. Rising prevalence of non-B HIV-1 subtypes in North Carolina and evidence for local onward transmission. Deathbed phenomena: its role in peaceful death and terminal restlessness. The adrenal gland is a major site of AKR1B expression mobic 15 mg tabletten in both human (AKR1B1) and mouse (AKR1B3, AKR1B7). Application of the myograph in studies on rabbit coronary arteries is demonstrated by a length-tension diagram obtained in experiments with tubular segments (inner diameter about 500 micron) of the circumflex branch on the left coronary artery, which shows a typical course in development of active and passive tension of the smooth musculature when exposed to alternating potassium depolarization and increasing mechanical stretching. The results obtained highlight the importance of clay minerals in governing the sorption of phenanthrene in soil, and emphasize the inapplicability of the carbon-normalized distribution coefficient K(OC) in soils. The premanifest group was subdivided into A and B, based on the proximity to estimated disease onset, the manifest group into stages 1 and 2, according to their Total Functional Capacity scores.

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The same mutations that prevent phospholipid binding of the isolated C2 domain in vitro abolished the calcium-dependent translocation of cPLA2 to internal membranes in vivo, suggesting that the membrane targeting is driven largely by direct interactions with the phospholipid bilayer. Is there preliminary in-vivo evidence for an influence of nonsteroidal antiinflammatory drugs on progression in osteoarthritis?. We must be aware that BPPV may involve multiple canals and how much does generic paxil cost without insurance may be associated with central lesions. A new method of measuring oxygen consumed in the metabolism of small animals. In cultured mammalian cells, the effect of photoactivated pyr-TFO-directed DNA damage was to induce mutations, in the form of deletions, approximately 7-fold over background levels, at the targeted site. These observations suggest that patients with localized systemic-to-pulmonary shunt could exhibit modified vascular tone in remote pulmonary arteries.

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The results showed that dyslexic children failed to learn the sequence when they were not informed about its presence (implicit condition). A number of other signaling systems are also involved in regulation of the main steps of vessel formation. After 6 sporadic cases, this is the first instance of siblings with the acrocallosal syndrome. The ventral septal area: electrophysiological evidence tenormin generic drug name for putative arginine vasopressin projections onto thermoresponsive neurons. Presidential address: China, then and now--a personal perspective. Recently, several signalling molecules such as Trim, PLD, ARF-1 and TIRC7 have been described to be involved in the transport of CTLA-4 to the cell surface.

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Implants of material 3 were remarkable in that, while surrounded by an inflammatory infiltrate and a fibrous capsule, they did not show any disturbance even at 24 weeks. Combining fractal aerosils and polymer constitutes an original way to realize promising dental composites. Deletion analysis shows that the clathrin-binding motif and the J-domain, when over-expressed, are sufficient for rescuing dAux phenotypes, implying that the recruitment of Hsc70 to clathrin is a critical role for dAux. A new class of equilibria with all pairwise linkage disequilibria zero, but with third order linkage disequilibrium, has been discovered. Transmission disequilibrium studies in early onset of obsessive-compulsive disorder for polymorphisms in genes of the dopaminergic system.

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Skin-autofluorescence, a measure of tissue advanced glycation end-products (AGEs), is related to diastolic function in dialysis patients. To identify barriers unique to young women, we compared them to a group of young men of similar age from the LRGV who also were aspiring to a health career. Is survival after radical cystectomy for bladder cancer in Saudi patients different from that of Western patients?. The study showed the presence of a prolonged pituitary activity during the luteinization process, which seems to be modulated by an interaction between P and LH. Mesoporous films obtained by dip-coating, combining polycondensation of silicate species and organization of amphiphilic mesophases, were decorated with iron-based nanoparticles from iron aqueous solution. The purpose of the current study was to assess the prevalence of and the risk factors associated with stunting and severe stunting among children aged less than five years in North Maluku province of Indonesia. Sulfur - Containing Amino Acids Homocysteine And Taurine In Seizures: Current State Of The Art. The closed loop between heart period and systolic arterial pressure was detected as open at the level of the baroreflex if systolic arterial pressure is more easily predictable from heart period than vice versa according to a conditional entropy approach. This paper reports a case of a spontaneous regression of a large lumbar disc extrusion. Agranulocytosis caused by ethosuximide is extremely rare in children.

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Assessment of comprehensive nutritional status and eating behavior among 311 middle aged and aged women with osteoporosis in Chengdu. TERS also activated Wnt signaling in recipient cancer cells and enhanced resistance to nutrient starvation and common chemotherapies such as the proteasome inhibitor bortezomib and the microtubule inhibitor paclitaxel. We report that antibody binding to infected CD4 T cells is highly variable and correlates with ADCML and ADCC processes. The different diagnosis should include infectious abscess, ureteral injury with urinoma, pancreatic injury with pseudocyst formation, and spinal fluid leak with pseudomeningocele. Although absence seizures and absence status are two distinct conditions, they should not be considered together. Septic pulmonary embolus is a rare disorder that classically presents with fever, respiratory symptoms, and lung infiltrates. After the nerve is cut, the Merkel cells and the dome ultimately disappear.2. Effect of Rosuvastatin on Carotid Intima-Media Thickness in Children With Heterozygous Familial Hypercholesterolemia: The CHARON Study (Hypercholesterolemia in Children and Adolescents Taking Rosuvastatin Open Label). Studies on first phases of development of colonies S and R of Escherichia coli.

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Contribution to the clinical aspects of postpartum hypophysealdiencephalic symptom complexes. Human immunodeficiency virus (HIV) Gag precursor protein is cleaved by viral protease (PR) within GagPol precursor protein to produce the mature matrix (MA), capsid, nucleocapsid, and p6 domains. When adaptation occurred, this was specific for the stressor which the animals were repeatedly exposed to. We recommend that it be used to analyse non-displaced fractures of the lateral humeral condyle in children. We developed a formulation using the continuous least-squares method to determine the inclined toroidal surface that best fits a given off-axis conic section.

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