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Alpramax (Alprazolam)

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Alpramax is a potent, short-acting benzodiazepine anxiolytic—a minor tranquilizer. It is commonly used for the treatment of anxiety disorders, especially of panic disorder. It's also used in the treatment of generalized anxiety disorder (GAD) or social anxiety disorder. It was the 12th most prescribed medicine in the United States in 2010. Alpramax, like other benzodiazepines, binds to specific sites on the GABAA receptor. It possesses anxiolytic, sedative, hypnotic, skeletal muscle relaxant, anticonvulsant, amnestic, and antidepressant properties. Alpramax is available for oral administration as compressed tablets (CT) and extended-release capsules (XR).

Other names for this medication:
Aldip, Alflux, Alpanol, Alprawin, Alprax, Alzep, Alzoact, Alzomax, Anquil, Anxico, Avizolem, Cardilax, Dazolam, Depflu, Depser, Enxolam, Erazol, Esteem, Kaprolam, Maxorest, Mebasap, Morecalm, Nokzok, Notence, Omelam, Orten, Plaxid, Resolin, Riolam, Selam, Setlan, Tenan, Tranisol, Xycalm, Zenax, Zocam, Zopral

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Also known as: Alprazolam


Alpramax is a benzodiazepine (ben-zoe-dye-AZE-eh-peen). Alprazolam affects chemicals in the brain that may be unbalanced in people with anxiety. Alpramax is used to treat anxiety disorders, panic disorders, and anxiety caused by depression.

You should not use Alpramax if you have narrow-angle glaucoma, if you also take itraconazole or ketoconazole, or if you are allergic to Alpramax or similar medicines (Valium, Ativan, Tranxene, and others).

Alprazolam may be habit-forming. Misuse of habit-forming medicine can cause addiction, overdose, or death.

Do not drink alcohol while taking Alpramax. This medication can increase the effects of alcohol. Alprazolam may be habit-forming and should be used only by the person for whom it was prescribed. Keep the medication in a secure place where others cannot get to it.


This section provides information on the proper use of a number of products that contain alprazolam. It may not be specific to Alpramax XR. Please read with care.

Take this medicine only as directed by your doctor. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered. If too much of this medicine is used for a long time, it may become habit-forming (causing mental or physical dependence) or cause an overdose.

This medicine should come with a Medication Guide. Read and follow the instructions carefully. Ask your doctor if you have any questions.

Swallow the extended-release tablet or tablet whole with a full glass of water. Do not break, crush, or chew it.

If you are using the orally disintegrating tablet, make sure your hands are dry before you handle the tablet. Do not remove the tablets from the bottle until you are ready to take it. Place the tablet immediately on the top of your tongue. It should melt quickly and be swallowed with saliva.

If you are using the oral liquid, measure the dose with a marked measuring spoon, oral syringe, or medicine cup.

Do not eat grapefruit or drink grapefruit juice while you are using this medicine.

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

For anxiety: For oral dosage forms (solution, tablets, or orally disintegrating tablets): Adults—At first, 0.25 to 0.5 milligram (mg) 3 times a day. Your doctor may increase your dose as needed. However, the dose is usually not more than 4 mg per day. Older adults—At first, 0.25 mg 2 or 3 times a day. Your doctor may increase your dose as needed. Children—Use and dose must be determined by your doctor. For panic disorder: For oral dosage form (extended-release tablets): Adults—At first, 0.5 to 1 milligram (mg) taken in the morning once a day. Your doctor may increase your dose as needed. However, the dose is usually not more than 10 mg per day. Older adults—At first, 0.5 mg taken in the morning once a day. Your doctor may increase your dose as needed. Children—Use and dose must be determined by your doctor. For oral dosage forms (solution, tablets, or orally disintegrating tablets): Adults—At first, 0.5 milligram (mg) 3 times a day. Your doctor may increase your dose as needed. However, the dose is usually not more than 10 mg per day. Older adults—At first, 0.25 mg 2 or 3 times a day. Your doctor may increase your dose as needed. Children—Use and dose must be determined by your doctor.


Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. An overdose of alprazolam can be fatal.

Overdose symptoms may include extreme drowsiness, confusion, muscle weakness, loss of balance or coordination, feeling light-headed, and fainting.


Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

It is very important to protect the orally disintegrating tablets from moisture. Remove and throw away any cotton packaging from the medicine bottle when you first use the medicine.

Detailed Alpramax dosage information

Side effects

The most common side effects associated with Alpramax are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

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Effect of portal-systemic anastomosis on renal haemodynamics in cirrhosis. Using the perforated test surface significantly increased the peel bond strength for all the materials tested. The work of breathing increased with increasing ventilatory rate, tidal volume, and decreasing tube diameter. Thyrotropin-releasing hormone facilitates display of reproductive behavior and locomotor behavior in an amphibian. Systematic discovery of novel eukaryotic transcriptional regulators using sequence homology independent prediction. This study examined the pathophysiology of the myocaridal damage produced by direct current shock over a dose range of 10 to 90 watt-seconds, applied directly to the heart in 26 dosgs. Interestingly, the infiltration by Tregs protected a second islet transplant, indicating systemic tolerance to islet antigens. Juiciness, tenderness, Warner-Bratzler shear force, pork flavor intensity and sensory scores were not consistently affected by male condition or zeranol treatment.

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Promoting Mental Health in Italian Middle and High School: A Pilot Study. An average of 9 weeks later, patients returned for a second visit. A technique is presented by which chromosomal mutations may be efficiently transferred onto chimeric multicopy plasmids in vivo. The chronic alcohol intoxication of rats has an opposite (as compared to the acute intoxication) effect on changes in the content of ascorbic and dehydroascorbic acids in the studied organs. Responses of the basilar artery to products released by platelets during chronic hypertension. Comparison of infrared-excited up-converting phosphors and europium nanoparticles as labels in a two-site immunoassay. Homolytic reactive mass spectrometry of fullerenes: peculiarities of the reactions of C60 with aromatic compounds in the ionization chambers of mass spectrometers and in solution.

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To observe the choices of conventional disease modifying antirheumatic drugs (cDMARDs) and biologic DMARDs (bDMARDs) in the management of rheumatoid arthritis (RA) in Australian routine clinical practice, to assess treatment survival and determine the effect of cDMARDs/bDMARDs on disease activity. Analysis of the tumor cells isolated from the malignant ascites revealed a substantial increase in TAG-72 expression on the surface of tumor cells isolated from seven of eight patients. A brief introduction of the meat industry, in particular the production and consumption trend in these countries, is provided in this article. Daily marathon running for a week--the biochemical and body compositional effects of participation. The weekly rate of change of stable fly populations showed four peaks which were attributed to the emergence of an initial generation which had overwintered, followed by an additional three generations. People who are exposed to nongenotoxic bladder carcinogens that are present in the environment and that form bladder stones, therefore, may be at an increased risk for developing bladder cancer if they are also exposed to tumor promoters, such as indomethacin. The extent of release which is reached during this procedure is controversially discussed. This study examines the effect of bolus administration of 5 mg of epinephrine when given as an agent of last resort for cardiac arrest. Minor analgesic use among high-school students: indications for renal morbidity and mortality. Lysosomal enzymes in the human endometrium: a biochemical study in untreated and levonorgestrel-treated women.

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Immunochemical investigations on lipopolysaccharides and acidic polysaccharides from serum-sensitive and serum-resistant strains of Escherichia coli isolated from urinary-tract infections. There are reports of disease activity in different corners of India since 2004. Effects of amphotericin B and three azole derivatives on the lipids of yeast cells of Paracoccidioides brasiliensis. Applied to three series of crania of differing provenance, the results indicate a continuity in expression of the trait rather than the dichotomous character utilized in previous studies. Age-related changes in maxillary and mandibular cortical bone thickness in relation to temporary anchorage device placement.

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Effect of retinal illuminance and eccentricity on border enhancement extent. As a typical endosymbiosis, AM interactions involves the differentiation of both symbionts to create novel symbiotic interfaces within the root cells, and requires a continuous nutrient exchange between the two partners. Microspheres sieved out in the first capillary bed encountered, the lung, then following biodegradation they disappeared at a rate dependent on the amount of cross-linking agent used in their preparation. The greatest effect is recorded in the range of 5000--1000 Hz both for sound oscillations and electromagnetic field. If diagnosed early and treated adequately, a majority of patients with globe perforation during periocular anaesthetic could be saved. Cloning and expression in mammalian cells of porcine tumor necrosis factor alpha: examination of biological properties. The force plate can measure a wide range of effects in the horse.

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This study shows that flexoelectricity could be an effective driving force for ion transport through membrane pores and channels, thus further highlighting the possible biological significance of this mechano-electric phenomenon. Effect of furosemide administration on systemic circulation of ponies during severe exercise. Sperm associations in the male reproductive tract of Eurycea longicauda (Amphibia: Caudata). Both detrusor cells and urothelium can serve as a source of elevated IL-6 levels. Effect of chromium ion and antioxidant N-acetyl-cysteine on morphology of human osteoblast-like MG63 cell line. It has been found that patterns of inferred gaps in alignments contain information towards the true phylogeny, but it is as yet unknown whether gaps are simply reflecting information that was already present in the guide-tree. These data may help project the duration of phytonadione treatment required in future cases of brodifacoum poisoning. 3-Hydroxy-3-methylglutaryl coenzyme A reductase inhibitors (statins) inhibit synthesis of isoprenoids, which are necessary for membrane translocation and activation of small GTPases like RhoA and Ras. Flow cytometry demonstrated negligible expression of (alpha)v(beta)3 by (beta)1A-GD25 and (alpha)2(beta)1A-GD25 cells when compared to GD25 cells.

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Bile acid metabolism and duodenal bacterial flora were studied in 12 obese patients before and 1-2 months after jejunoileal bypass operation, either including 37.5 cm jejunum and 12.5 cm ileum (Type I roxithromycin capsule ) or 12.5 cm jejunum and 37.5 cm ileum (Type III). WHO Expert Committee on Specifications for Pharmaceutical Preparations. Demonstration of 5-HT(3) receptor function and expression in the mouse bladder. We previously demonstrated that rat cerebello-thalamic synapses undergo an ultrastructural change, consistent with expression of long-term potentiation, in association with motor adaptation. Because phospholipases A2 and C have been proposed to regulate prostanoid synthesis, we examined the effect of leukotriene D4 on these activities. No intrapair differences were found in GMV between discordant affected twins and their healthy co-twins. Grwoth response of Muscovy ducklings to thyroxine (iodinated casein). Sera containing immune complexes or platelet autoantibodies revealed positive surface staining for IgG, or for IgG and IgM. Evaluation of a non-invasive technique to assess cardiac function. Using a methylcellulose cell culture technique, we studied the serial changes in erythropoietic precursors in the femur, spleen, and blood of mice under erythropoietic stimuli.

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Subjective well-being of visually impaired older adults living in the community. The DSTM consists of two compact STMs, each having x, y, and z coarse positioning piezoelectric steppers with embedded capacitive positioning sensor for navigation. Data were analyzed through the technique of constant comparative analysis. To a lesser degree it was demonstrated in the kidney, where some--probably the actually functioning--nephrons give positive staining reactions within their tubular cells. The promotion of urate crystal formation by gouty synovial fluid was not due to native urate crystals nor to an effect on the level of urate supersaturation. There is minimal surface reactivity regeneration with time or via exposure to high relative humidity. More recently, the British Medical Research Council Adjuvant Gastric Cancer Infusional Chemotherapy (MAGIC) study found that preoperative and postoperative administration of epirubicin, cisplatin, and 5-fluorouracil significantly improved survival beyond surgery alone.

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