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Alpostin (Alprostadil)

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Alpostin injection and suppositories are used to treat certain types of erectile dysfunction (impotence; inability to get or keep an erection) in men. Alpostin is in a class of medications called vasodilators. It works by relaxing the muscles and blood vessels in the penis to keep enough blood in the penis so that an erection can occur.

Other names for this medication:
Alpostin, Caverject, Edex, Muse, Prostin, Vitaros

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Also known as: Alprostadil


Alpostin injection is used to treat men who have erectile dysfunction (also called sexual impotence). It belongs to a group of medicines called vasodilators that can increase blood flow by expanding blood vessels. This medicine causes an erection because it increases the blood flow to the penis.

Alpostin should not be used as a sexual aid by men who do not have erectile dysfunction. If the medicine is not used properly, permanent damage to the penis and loss of the ability to have erections could result.

Alpostin is used alone or with medical tests to help diagnose erectile dysfunction that may be caused by nerve or blood vessel problems in the penis.

This medicine is available only with your doctor's prescription.

This product is available in the following dosage forms:

  • Powder for Solution
  • Solution


Read the manufacturer's patient instructions before you start using this medication and each time you get a refill. Learn all preparation and usage instructions in the product package. If any of the information is unclear, consult your doctor or pharmacist. This medication is given by injection into the penis as directed by your doctor. Before injecting each dose, clean the injection site with rubbing alcohol. It is important to change the location of the injection site with each dose to avoid problem areas under the skin. Therefore, choose an injection site on the other side of the penis from the site of the last dose, using a different area each time. After injection, apply pressure to the injection site with an alcohol swab for about 5 minutes to avoid bruising. Dosage is based on your medical condition and response to therapy. This medication should usually work within 5 to 20 minutes to produce an erection that lasts for about 1 hour. The manufacturer recommends that this medication be used no more than 3 times a week with at least 1 day between each dose. Before using, check this product visually for particles or discoloration. If either is present, do not use the liquid. Learn how to store and discard needles and medical supplies safely. Consult your pharmacist. Inform your doctor if your condition persists or worsens (e. g. , the drug does not produce an erection or it becomes more difficult to get an erection).


If overdose is suspected, contact a poison control center or emergency room immediately. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center. Symptoms of overdose may include: fainting, painful/prolonged erection.


Store unopened foil pouches in the refrigerator at 36-46 degrees F (2-8 degrees C). If necessary, this product may also be stored at room temperature below 86 degrees F (30 degrees C) for up to 14 days. Keep all medicines away from children and pets. Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company for more details about how to safely discard your product.

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Chaperone activity of bicyclic nojirimycin analogues for Gaucher mutations in comparison with N-(n-nonyl)deoxynojirimycin. Brain tissue binding of drugs: evaluation and validation of solid supported porcine brain membrane vesicles (TRANSIL) as a novel high-throughput method. Targeting health care resources for CVD by geographic variation may not be appropriate for older age-groups. Sensitive determination of a drug candidate in dried blood spots using a TLC-MS interface integrated into a column-switching LC-MS/MS system. Our results suggest that CRH act on CRH-R1 to stimulate SGK-1 mRNA and protein expression in cultured hippocampal neurons via a mechanism that is involved in AC/PKA signaling pathways. Patients were classified by the extent of colonic disease: limited left-sided colitis (LSC), pancolitis and any disease extent with concurrent primary sclerosing cholangitis. These intriguing structural differences between the two DAP5 isoforms suggest that they have different interaction partners and, subsequently, different functions. National health expenditures and related measures for the year ending in March 1980.

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In order to enhance transparency and consistency, a format called the upstream-operating-downstream framework (UOD) is proposed for reporting basic technology-related data regarding GHG issues including a clear distinction between direct emissions from waste management technologies, indirect upstream (use of energy and materials) and indirect downstream (production of energy, delivery of secondary materials) activities. Diagnostic anatomic pathologists have to resolve a number of conflicts. Hybrid scanners, which enable the performance of single photon emission computed tomography (SPECT) and X-ray computed tomography (CT) in one imaging session, have considerable diagnostic potential. The effects of PrRP on IPSCs in OLETF rats were similar to those in wild-type rats. We found evidence, of moderate quality, that radiation decreases the risk of disease progression compared with no further treatment, but little evidence that it might improve overall survival. Meta-analysis techniques are powerful tools used to combine results from many similar trials in which the response of interest is either small (i.e., continuous variables) or of low frequency (i.e., discrete variables). Transgenic mice expressing nitroreductase gene under the control of the podocin promoter: a new murine model of inductible glomerular injury.

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Removal of surgical silk from the bronchus after lung resection in tuberculosis. Results of immunohistochemical studies were consistent with a tumor of neuroectodermal origin. Group II mGluRs are required for persistent hippocampal long-term depression (LTD), but are not required for long-term potentiation (LTP) in the hippocampal CA1 region in vivo. Implementing the SCCM Family-Centered Care Guidelines in Critical Care Nursing Practice. The review does not point to a clear bio-behavioral target for psychiatric nursing intervention.

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Vascular access thrombosis increases morbidity in hemodialysis (HD) patients. To investigate the risk factors and the predictors of pharyngeal acid reflux (PAR) in Taiwanese patients with suspected reflux laryngitis. Younger diabetics were significantly more likely to use force and a weapon in their offenses and were most likely to injure their victims when compared to older diabetics and younger and older non-diabetic offenders. Moreover, the CD133 cells that show surface markers for CD34 are stem cells primitive. This study investigated urinary excretion of different solutes, particularly citrate and acids, in kidney stone formers and examined their association with high blood pressure. Results are presented for a set of numerical experiments in which the radius interval for which the distribution function can be obtained with a satisfactory accuracy is estimated. This case allows direct comparison between the histologic findings in a giant cell glioblastoma and a ganglioglioma and documents the aggressive biologic behavior of this complex neoplasm. Yet the biological impact of rising temperatures also depends on the physiological sensitivity of organisms to temperature change.

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White matter compromise of callosal and subcortical fiber tracts in children with autism spectrum disorder: a diffusion tensor imaging study. It also provided the basis for investigations on the role of GILT in cipro dosage in renal failure this important domestic species and an animal model for human diseases. The CaR is expressed in all nephron segments, but its effects on ion and water transport in specific segments as well as the mechanisms by which it regulates ion and water transport is not fully understood. The laboratory-made stationary phases presented chemical stabilities in phosphate solution more than three times better their chemical stabilities in carbonate buffer. Reciprocal interactions between cells in the MS and adipocytes regulate their immune and metabolic functions. Although complications of the syndrome may involve the eye, the lung and the skeleton, the high mortality of untreated cases results almost exclusively from cardiovascular complications, including aortic dissection and rupture. In the transgenic animals, we observed that the immature and mature enamel appeared normal. As such, in vitro studies are necessary precursors to in vivo ASC applications.

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Characterization of hepatocellular resistance and susceptibility to styrene toxicity in B6C3F1 mice. A model for the development and implementation of a quality assurance programme in a long term care facility. Mammalian Sprouty (Spry) proteins are known to function by specifically antagonizing the activation of the mitogen-activated protein kinase signaling pathway by receptor tyrosine kinases, a pathway known to promote angiogenesis. We describe all identified as well as possible (candidate) adapter TLR molecules by giving their brief characteristics, and we also propose generalized possible variants of the TLR ligand-specific recognition with involvement of adapter molecules. Transition is a complex and continuous process that requires careful planning. An appropriate amount of hair dye sample is dissolved in 10 ml of methanol containing 0.25 g of ammonium thioglycolate and an appropriate amount of 2-amino-4-methylphenol as an internal standard. DNA replication in the epithelium of rat vagina and lower cervix following estrogen-progesterone treatment (1,2). In contrast, when the utility of familiarity was undermined by using pseudohomophones, additivity was observed in the means but not in distributional characteristics. We investigated clinicopathological factors as determinants of survival in patients with MCC submitted to sentinel node biopsy. Is replacement modality choice knowledge important in the non-renal multidisciplinary team?.

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