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Alphadol (Calcitriol)

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Alphadol is an active metabolite of vitamin D that is used to treat hyperparathyroidism and is also used in dialysis patients to combat hypocalcemia. Alphadol is a biologically active calcitrophic hormone with anti-osteoporotic, immunomodulatory, anticarcinogenic, antipsoriatic, antioxidant, and mood-modulatory activities.

Other names for this medication:
Admax, Alfabond, Alfacip, Biocal, Biocitral, Bonetuf, Calasto, Calbec, Calcibest, Calcor, Calfa, Calotec, Calsure, Caltin, Caltop, Cholical, Citroj, Coecoral, Dmcal, Duracal, Estovon, Fovit, Ikmag, Koncal, Kurecal, Lctrol, Nutribone, Osteobel, Primacal, Qpcal, Roical, Rolsical, Solbiocal, Sorvate, Trolec, Zaxial

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Also known as: Calcitriol


Vitamins are compounds that you must have for growth and health. They are needed in small amounts only and are available in the foods that you eat. Vitamin D is necessary for strong bones and teeth.

Lack of vitamin D may lead to a condition called rickets, especially in children, in which bones and teeth are weak. In adults it may cause a condition called osteomalacia, in which calcium is lost from bones so that they become weak. Your doctor may treat these problems by prescribing vitamin D for you. Vitamin D is also sometimes used to treat other diseases in which calcium is not used properly by the body.

Ergocalciferol is the form of vitamin D used in vitamin supplements.

Some conditions may increase your need for vitamin D. These include:

Alcoholism Intestine diseases Kidney disease Liver disease Overactivity of the parathyroid glands with kidney failure Pancreas disease Surgical removal of stomach

In addition, individuals and breast-fed infants who lack exposure to sunlight, as well as dark-skinned individuals, may be more likely to have a vitamin D deficiency. Increased need for vitamin D should be determined by your health care professional.

Alfacalcidol, calcifediol, calcitriol, and dihydrotachysterol are forms of vitamin D used to treat hypocalcemia (not enough calcium in the blood). Alfacalcidol, calcifediol, and calcitriol are also used to treat certain types of bone disease that may occur with kidney disease in patients who are undergoing kidney dialysis.

Claims that vitamin D is effective for treatment of arthritis and prevention of nearsightedness or nerve problems have not been proven. Some psoriasis patients may benefit from vitamin D supplements; however, controlled studies have not been performed.

Injectable vitamin D is given by or under the supervision of a health care professional. Some strengths of ergocalciferol and all strengths of alfacalcidol, calcifediol, calcitriol, and dihydrotachysterol are available only with your doctor's prescription. Other strengths of ergocalciferol are available without a prescription. However, it may be a good idea to check with your health care professional before taking vitamin D on your own. Taking large amounts over long periods may cause serious unwanted effects.


Generic Alphadol is available in capsules (0.25 mcg) and liquid form. Capsules must be swallowed whole. Do not crush or chew them. If you are prescribed the liquid form, use as directed. Follow dosing instructions closely. Do not take this medication with mineral oil or magnesium containing antacids which may reduce its effects. Foods rich in vitamin D include: fortified dairy products, eggs, sardines, cod liver oil, chicken livers and fresh-water fish. Vitamin D is also obtained from periodic exposure to the sun. It is important to maintain a well-balanced diet while taking this medication. Calcium supplements may be recommended in addition to this medication. If you want to achieve most effective results do not stop taking Generic Alphadol suddenly.


If you overdose Generic Alphadol and you don't feel good you should visit your doctor or health care provider immediately.


Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F) away from moisture, light and heat. Keep container tightly closed. Throw away any unused medicine after the expiration date. Keep out of the reach of children.

Side effects

The most common side effects associated with Alphadol are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


Problems in older adults have not been reported with intake of normal daily recommended amounts. Studies have shown that older adults may have lower blood levels of vitamin D than younger adults, especially those who have little exposure to sunlight. Your health care professional may recommend that you take a vitamin supplement that contains vitamin D.

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Characteristics of aggregation of human platelets by bovine factor VIII. In the absence of a documented genetic profile and family history, awareness of these features should help us to diagnose clear cell pancreatic NETs resembling metastatic renal cell carcinoma. If spheroids from this squamous cell carcinoma cell line may be regarded as a relevant model system for their in vivo counterparts, then the results from the present study may indicate that accelerated fractionation of treatment is advantageous for small lesions, but not for larger tumours. Ultrastructural alterations in mammalian parathyroid glands induced by fixation. In the future, combination antiviral therapy may limit the development of resistance. In the model, the zwitterionic lipid bilayer is assumed to be in contact with aqueous solution of monovalent salt ions. This modality has outlived many other intravascular techniques 26 years after its inception. Nevertheless, our demonstration that polymorphism in T cell receptor (TcR) alpha chain are related to MS and that, in demyelinating lesions, TcR usage is limited, suggests that T cells may recognise particular epitopes of a critical antigen involved in this disease. A retrospective non-controlled clinical study of the data of patients who underwent Artisan PIOLs between March 2006 and July 2008 was evaluated.

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Characteristic of the neurotic patients was a tendency toward overcoming problems in a passive manner. Protein-energy malnutrition (PEM) is a major public health problem in the tropical and subtropical regions of the world and often arises during protein and / or energy deficit due to nutritional inadequacy, infections and poor socio-economic and environmental conditions. New targets for the cyclic AMP receptor protein in the Escherichia coli K-12 genome. ovata may be able to rapidly colonize benthic substrates outcompeting other species. Murine peritoneal macrophages were preincubated with amphotericin B (AMPH) and were then stimulated with bacterial lipopolysaccharide or streptococcal preparation (OK432).

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Significant renal damage can result from the first episode of urinary tract infection. DNA-bound LexA-SNF2 fusion protein also activated transcription, dependent on SNF5 and SNF6. Upon disruption of the plant material, as in food preparation or chewing, a thioglucosidase-mediated autolytic process ensues generating indole-3-carbinol (I3C), glucose, and thiocyanate ion. The yield and all the biological assays performed on the DNAs obtained by our method recommend it for routine laboratory use. The cDNA-derived amino acid sequences of the alpha chains of adult hemoglobins B and C: their roles in deoxygenation-induced aggregation. This review aims to discuss the various factors impacting surface sampling of viruses from fomites and to explore how researchers could move towards a more sensitive and standard sampling method. These findings identify C/EBPbeta as a direct activator of E2F target genes in mammalian cell cycle progression through a mechanism that involves recruitment of CBP/p300.

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calcitriol 2018-02-26

A CT scanner suggests the presence of a gastro- esophageal-pericardial fistula. It was formerly described in Japan, and subsequently in other countries and in Italy as an anatomo-clinical entity. Okadaic acid also inhibited secretion induced by the calcium ionophore A23187, in the presence or absence of PMA, indicating that the phosphatase inhibitors act on a component of the secretory pathway downstream of calcium mobilization. Bim, a proapoptotic BH3-only member of the Bcl-2 family should diflucan be taken after antibiotics is required for initiation of apoptosis induced by cytokine deprivation or certain stress stimuli. In this study, we cloned the cDNAs encoding two betaPix isoforms from mouse brain cDNA library. The aphC promoter in strain TA441 was not silenced, unlike the cases of the aphK and aphR promoters, and was highly induced by HMS.

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Rabbit placental relaxin: purification and immunohistochemical localization. We present a patient with recently diagnosed osteosarcoma of the right femur, showing abdominal wall metastasis diagnosed by technetium-99m-methylene diphosphonate (99m Tc-MDP) whole body bone scintigraphy and confirmed histologically. These results suggest that phonological working memory is related to the function of cortical structures that canonically underlie speech perception and production. Some of them are accepted as valid and others are still discussed. Double-blind crossover trial of bisolvon in the treatment of chronic bronchitis. Effects of pH and concentration of sodium citrate anticoagulant on platelet aggregation measured by light transmission aggregometry induced by adenosine diphosphate. Lung cancer is a rapidly progressing, often life-threatening disease that constitutes a huge societal burden.

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Females, problem-oriented dental attenders, and participants who had not completed high school were significantly more dissatisfied with their dental appearance than their respective counterparts. Guidelines for obstetrical scanning and reporting: the legal necessity. Toxicity at higher concentrations of adenosine is adenosine kinase independent and is potentiated by homocysteine thiolactone. This text reviews and updates the uses of the reference procedures for antifungal susceptibility testing in yeasts, the reliability of the commercial methods and the guidelines for the use of these procedures for patient management and for epidemiological reasons to determine the susceptibility profile and the emergence of resistances. Our objective was to evaluate right ventricular echocardiographic and hemodynamic predictors of mortality in a cohort of patients with IPF referred for lung transplant evaluation. The authors describe an uncommon localization of fibromuscular dysplasia in the superficial femoral artery. The octopus protocadherin expansion shares features with the mammalian clustered protocadherins, including enrichment in neural tissues, clustered head-to-tail orientations zetia dose range in the genome, and a large first exon encoding all cadherin domains. Liver toxicity generally produces liver cell death, while cardiac toxicity causes adverse changes in heart beat kinetics.

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The purpose of this paper is to provide psychiatrists with practical advice on how to detect malingered mental illness. The drug also reduced levels of C-reactive protein in the synovial fluid taken from the affected stifle joint. In ICS patients, asthma control was maintained with FP200QD, whereas FP100BID provided greater improvements in pulmonary function and asthma stability. Intraoperative injury of bladder was observed in 2 children with sliding inguinal hernia. Modern antiviral strategies are effective in controlling the clinical syndromes associated with acute cytomegalovirus infection in heart transplant recipients. It took them more time to accomplish these tasks and they made different mistakes as compared to normal.

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In this model study, Ppa thus showed effects in healthy individuals. The investigated regions of dura mater after noise-vibration stress the magnitude of harmonics, mesor and the amplitude of fluctuations increased greatly. For this reason we often use in the same time a 99mTc stannous pyrophosphates scintigraphy of rachis. The duration of individual bouts ranged from 2 to 100 seconds, and their dynamics exhibited local homeostasis: the duration of bouts of ativan tablet uses quiescence positively correlated with the duration of bouts of motion that immediately preceded them in a cAMP-dependent manner. However, due to different diffusion properties of the compound in tissue, the RR in vivo is different from the RR in vitro. These neuropathies are linked to heterozygosity for missense mutations in five ARS genes, which points to a shared mechanism of disease.

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Minimizing the discrepancy between implant platform and alveolar bone for tilted implants with a sloped implant platform: A clinical report. Cellophane paper has been used as a dressing for split-thickness skin graft donor sites in 251 patients between October 1985 and December 1989. AtTPK1 and AtTPK2 are biochemically redundant cytosolic proteins that are similarly expressed throughout different plant tissues. These data demonstrate excellent agreement between this out-of-laboratory system and polysomnography in its ability to detect accurately RDI, PLM index, and saturation levels. Postoperative alignment of TKA indapamide equivalent dose in patients with severe preoperative varus or valgus deformity: is there a difference between surgical techniques?. Direct determination of selenium in human serum by inductively coupled plasma-collision cell-mass spectrometry.

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Trachea segments were evaluated for degree of lumenal occlusion, as well as percent and type of lumen epithelial cell coverage. Between the other four treatments, all including surgery, no statistically significant differences in the 5-year relative survival rates were found. To clarify the influence of stromal cells on the 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2H tetrazolium bromide assay (MTT assay), a gastric carcinoma cell line (KATO-III) and a human fibroblast cell line (IMR-90) were subjected to a colorimetric assay, in which the chemosensitivity KATO-III was found to be highly sensitive to mitomycin C at 10 micrograms/ml, whereas IMR-90 was insensitive to mitomycin C at the same concentration. Post-operative drain output as a predictor of bladder neck contracture following radical prostatectomy. HIV1 infection of human monocytes and macrophages promotes induction or translocation of NF-KB-related factors. Influence of moderate beer consumption on aluminium toxico-kynetics: acute study. This response suggests that etoposide may be a useful agent in the management of histiocytosis X. Results showed a normal or slight hyper-response of GH up to 150 ng/ml, and normal somatomedin activity in those blood samples with high GH level. Comparative in vitro effects of cyclophosphamide derivatives on murine bone marrow-derived stromal and hemopoietic progenitor cell classes. DNI, DNM and DNC differ from one another principally in their directionality.

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Challenging declarations of abstinence by the determination of morphine in hair by radioimmunoassay. We identified alternatively spliced exons in a human alpha 6 genomic clone that encode X1- and X2-like segments. This effect on polarized cell growth did not appear to be due to an inability to establish cell polarity, since both the actin cytoskeleton and localization of the septin Cdc12p were unaffected by increased expression of Cdc42p, Cla4p, or Ste20p. We present current approaches to quantitate velocity patterns in the ophthalmic and retinal artery by Duplex ultrasound imaging. Indomethacin in the treatment of ureteral colic: is fluid restriction necessary?.

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The FGFR4 Gly388Arg polymorphism is associated with cancer and cardiovascular diseases, but its association with hypertension is unclear. The CBL and CIPK Gene Family in Grapevine (Vitis vinifera): Genome-Wide Analysis and Expression Profiles in Response to Various Abiotic Stresses. Lasers are now used can you mix seroquel and alcohol in many areas of medicine and may have applications in minimally invasive spinal surgery. Marked differences in the swainsonine inhibition of rat liver lysosomal alpha-D-mannosidase, rat liver Golgi mannosidase II, and jack bean alpha-D-mannosidase. We report a newborn with progressive leukoencephalopathy and lactic acidaemia, diagnosed with isolated sulfite oxidase deficiency.

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