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Aloxyn (Amoxicillin)
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Aloxyn

Aloxyn is a penicillin-like (beta-lactam) antibiotic. It belongs to the most widely-used group of antibiotics available. Aloxyn is usually the drug of choice within the class because it is better absorbed, following oral administration, than other beta-lactam antibiotics.

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Also known as: Amoxicillin

Description

Aloxyn (amoxicillin) is a penicillin antibiotic that fights bacteria.

Aloxyn is used to treat many different types of infection caused by bacteria, such as tonsillitis, bronchitis, pneumonia, and infections of the ear, nose, throat, skin, or urinary tract.

Aloxyn is also sometimes used together with another antibiotic called clarithromycin (Biaxin) to treat stomach ulcers caused by Helicobacter pylori infection. This combination is sometimes used with a stomach acid reducer called lansoprazole (Prevacid).

Dosage

Adults: 1 g PO once daily or 500 mg PO twice daily for 10 days. The American Heart Association (AHA) recommends extended-release Aloxyn as an alternative to penicillin V for rheumatic fever prophylaxis.

Infants, Children, and Adolescents: 25 mg/kg/dose (Max: 500 mg/dose) PO twice daily for 10 days is recommended by the Infectious Diseases Society of America (IDSA). Alternatively, 50 mg/kg/dose PO once daily (Max: 1 g/dose) for 10 days is recommended by The American Heart Association (AHA) as an alternative to penicillin V. For ear/nose/throat infections in general, the FDA-approved dosage is 20 mg/kg/day PO in divided doses every 8 hours (Max: 250 mg/dose) or 25 mg/kg/day PO in divided doses every 12 hours (Max: 500 mg/dose) for mild to moderate infections and 40 mg/kg/day PO in divided doses every 8 hours (Max: 500 mg/dose) or 45 mg/kg/day PO in divided doses every 12 hours (Max: 875 mg/dose) for severe infections.

Overdose

In case of overdosage, discontinue medication, treat symptomatically, and institute supportive measures as required. If the overdosage is very recent and there is no contraindication, an attempt at emesis or other means of removal of drug from the stomach may be performed. A prospective study of 51 pediatric patients at a poison-control center suggested that overdosages of less than 250 mg/kg of Aloxyn are not associated with significant clinical symptoms and do not require gastric emptying.

Interstitial nephritis resulting in oliguric renal failure has been reported in a small number of patients after overdosage with Aloxyn.

Crystalluria, in some cases leading to renal failure, has also been reported after Aloxyn overdosage in adult and pediatric patients. In case of overdosage, adequate fluid intake and diuresis should be maintained to reduce the risk of Aloxyn crystalluria.

Renal impairment appears to be reversible with cessation of drug administration. High blood levels may occur more readily in patients with impaired renal function because of decreased renal clearance of Aloxyn. Aloxyn may be removed from circulation by hemodialysis.

Storage

Store this medicine at room temperature, away from heat, light, and moisture.

Side effects

The most common side effects associated with Aloxyn are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

The possibility of superinfections with mycotic or bacterial pathogens should be kept in mind during therapy. If superinfections occur, Aloxyn should be discontinued and appropriate therapy instituted.

A high percentage of patients with mononucleosis who receive ampicillin develop an erythematous skin rash. Thus, ampicillin-class antibiotics should not be administered to patients with mononucleosis.

Prescribing Aloxyn in the absence of a proven or strongly suspected bacterial infection or a prophylactic indication is unlikely to provide benefit to the patient and increases the risk of the development of drug-resistant bacteria.

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