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Adefin (Nifedipine)

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Adefin is a dihydropyridine calcium channel blocker. Adefin is used to: treat high blood pressure (hypertension), prevent chronic stable angina (chest pain). Adefin was the first calcium channel blocker to be shown to significantly reduce the development of new overt heart failure in patients with coronary artery disease. Excellent blood-pressure control in recent clinical trials has been shown to result in significant protection against stroke. Adefin works by opening up blood vessels in the body to lower blood pressure and improve the supply of blood and oxygen to the heart. Calcium channel blockers do not change the amount of calcium in your blood or bones.

Other names for this medication:
Addos, Adefin, Anpect, Aprical, Atenerate, Buconif, Calcheck, Cardifen, Cardules, Casanmil, Chronadalate, Citilat, Coral, Cordaflex, Cordalat, Cordipin, Depine, Epilat, Milfadin, Nifecap, Nifecard, Nifecardia, Nifedalat, Nifedate, Nifedel, Nifedical, Nifedin, Nifedip, Nifedipine, Nifestad, Nilol, Nipidin, Nipin, Nyefax, Ospocard, Oxcord, Tensopin, Tredalat, Viscard

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Also known as: Nifedipine


Nifedipine is used alone or together with other medicines to treat severe chest pain (angina) or high blood pressure (hypertension). High blood pressure adds to the workload of the heart and arteries. If it continues for a long time, the heart and arteries may not function properly. This can damage the blood vessels of the brain, heart, and kidneys, resulting in a stroke, heart failure, or kidney failure. High blood pressure may also increase the risk of heart attacks. These problems may be less likely to occur if blood pressure is controlled.

Nifedipine is a calcium channel blocker. It works by affecting the movement of calcium into the cells of the heart and blood vessels. As a result, nifedipine relaxes blood vessels and increases the supply of blood and oxygen to the heart while reducing its workload.

This medicine is available only with your doctor's prescription.


This section provides information on the proper use of a number of products that contain nifedipine. It may not be specific to Adefin XL. Please read with care.

In addition to the use of this medicine, treatment for your high blood pressure may include weight control and changes in the types of foods you eat, especially foods high in sodium (salt). Your doctor will tell you which of these are most important for you. You should check with your doctor before changing your diet.

Many patients who have high blood pressure will not notice any signs of the problem. In fact, many may feel normal. It is very important that you take your medicine exactly as directed and that you keep your appointments with your doctor even if you feel well.

Remember that this medicine will not cure your high blood pressure, but it does help control it. You must continue to take it as directed if you expect to lower your blood pressure and keep it down. You may have to take high blood pressure medicine for the rest of your life. If high blood pressure is not treated, it can cause serious problems such as heart failure, blood vessel disease, stroke, or kidney disease.

Swallow the extended release tablet whole. Do not break, crush, or chew it. It is best to take this tablet on an empty stomach.

If you are taking the extended-release tablets, part of the tablet may pass into your stool after your body has absorbed the medicine. This is normal and nothing to worry about.

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

For treatment of chest pain or high blood pressure: For oral dosage form (capsules): Adults—At first, 10 milligrams (mg) three times a day. Your doctor may increase your dose as needed. Children—Use and dose must be determined by your doctor. For oral dosage form (extended-release tablets): Adults—At first, 30 or 60 milligrams (mg) once a day. Your doctor may increase your dose as needed. However, the dose is usually not more than 90 mg once a day. Children—Use and dose must be determined by your doctor.


If you overdose Adefin and you don't feel good you should visit your doctor or health care provider immediately.


Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Detailed Nifedipine dosage information

Side effects

The most common side effects associated with Adefin are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


Appropriate studies have not been performed on the relationship of age to the effects of nifedipine in the pediatric population. Safety and efficacy have not been established.

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To investigate the diversity of integrons and extended-spectrum beta-lactamases (ESBLs) among Enterobacteriaceae from chickens and swine in Portugal and analyse the clonal relationships between Portuguese ESBL-producing isolates of animal and human origin. Bone regeneration with active angiogenesis by basic fibroblast growth factor gene transfected mesenchymal stem cells seeded on porous beta-TCP ceramic scaffolds. Tropical diseases remain a significant threat to deployed military personnel as demonstrated by recent outbreaks amongst troops in Sierra Leone, Iraq and Afghanistan. The augmentation of the barbiturate effect in mice, by atropine and scopolamine. Thyroid-stimulating hormone location in the chicken pars distalis. Perinatal mortality, stillbirths and congenital anomalies are increased between two- and fourfold. These data support the hypothesis that a receptor distinct from CD14 functions as the actual signal transducer and suggest that surface binding of LPS to the cell membrane is the crucial first step for initiating downstream signaling events. Respiration rate decreased as oxygen tension decreased and approached zero at low oxygen tensions. Third, we use our experiences in neurobiology and human genetics to highlight how communication between clinical medicine and biomedical research lead to effective implementation of cross-species model organism approaches to uncover the biological underpinnings of health and disease.

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Using lumbar 5 (L5) dorsal root rhizotomy-bearing rats, we examined the extent to which L5 spinal nerve lesion (SNL)-induced mechanical hyperalgesia was governed by two peripheral components, that is Wallerian degeneration (WD) and peripherally-propagating injury discharge (PID). Advanced age, female gender, and a history of chronic renal failure, congestive heart failure, or chronic lung disease were predictive of perioperative death. The fate of phenolic compounds, along with short-chain fatty acids (SCFAs) production kinetics, was evaluated on six different commercial gluten-free (GF) pasta samples varying in ingredient compositions, focussing on the in vitro faecal fermentation after the gastrointestinal digestion. Recombinant Aczonin-CC3, expressed in cultured neurons as a green fluorescent protein fusion protein, is targeted to synapses and suppresses vesicle turnover, suggesting involvements in synaptic assembly as well as activity. Participants were matched with a control group of similar patients who did not receive a psychiatric diagnosis. The study was carried out in cooperation with the Danish National Board of Health. Measures of brain and hippocampal volume in 40 healthy young (aged 18-30 years) and 36 healthy elderly (aged 60-83 years) subjects were compared with composite cognitive function scores in three conceptual domains: memory ability, processing speed, and general fluid intelligence. Although patience is required to evolve them, these experimental channels offer the opportunity to explore several fundamental issues about river morphodynamics.

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Characterization of Al2O3 sintered pellets for dosimetric applications in radiotherapy. Much effort has been expended on interpreting the mechanism of influenza epidemics, so as to better predict them. Furthermore, meal size was significantly correlated with the gain of adipose tissue. Hospital pharmacy buying groups: the perspective of a contract sales manager. Cases of TdP are underreported and data on the incidence of TdP is scarce. In this study we evaluated the effects of the new NO donating compound (S,R)-3-phenyl-4,5-dihydro-5-isoxazole acetic acid-nitric oxide (GIT-27NO) on the A375 human melanoma cell line. We treated a case of congenital membranous stenosis of the esophagus successfully by transendoscopic incision. Crystal structures of cisplatin bound to a human copper chaperone. Effect of phospholipids on mebendazole pharmacokinetics in experimental multilocular echinococcosis. In the linear 1,040 km experiment, a Bit Error Rate (BER) of 10(-3) can you take cymbalta 60 mg twice a day was achieved with an Optical Signal-to-Noise Ratio (OSNR) penalty with respect to back-to-back of 2.9 dB, using two samples per bit and 16,384 trellis states.

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We report the complete data we have collected concerning abnormal Hb in Tunisia, and their local repartition. Our data suggests that the Shh transcriptional factor Gli2 regulates radial patterning of the bladder mesenchyma. The nitrile stretching vibration is increasingly used as a sensitive infrared probe of local protein environments. Molecular detection of hybridization between sympatric kangaroo species in south-eastern Australia. In native arteries, this J-shaped circumferential stress-strain curve arises primarily from initial load transfer to low stiffness elastic fibers followed by progressive recruitment and tensing of higher stiffness arterial collagen fibers. Characteristic findings of depressed early gastric cancer were summarized by neoplastic histological type according to the roentgenographic findings as follows: Undifferentiated cancer: The depressed surface shows many irregular changes and granular shadows of various biaxin what antibiotics treat tooth infection sizes. Levels of ammonia are also affected by proper sampling technique, transport, and analysis. Limited psychometric research has examined the reliability of self-reported measures of neighbourhood conditions, the effect of measurement error on associations between neighbourhood conditions and health, and potential differences in the reliabilities between neighbourhood strata (urban vs rural and low vs high poverty).

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Recent data suggest that lithium and valproate can protect gray matter in patients with bipolar disorder. Bioinformatics and systems biology approaches identified potential pathways that are regulated by these miRNAs. For incipient nephropathy, ideal therapy should bring about microalbuminuria regression. Spermagglutinin in normal serum and its relationship to homologous seminal plasma in cattle. Case presentation with corneal topographic correlation, along with the relevant literature pertaining to surgical techniques used in PMD. A comparison of the induction of myeloid and lymphoid leukemias in x-radiated RF mice. These changes in contact angle indicate that photo-induced aging processes involving ozone (such as oligomerisation) not necessarily favour increased hygroscopicity of organic aerosols in the atmosphere. Nu-Med plans to spin off 6 hospitals to new ESOP (employee stock ownership plan). However, pesticide overuse led to serious concerns for human health and the environment. These alterations were associated to the content and fatty acid composition of cardiolipin.

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