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Actalipid (Simvastatin)

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Actalipid is an inexpensive drug used to lower levels of cholesterol and triglycerides in the blood. Actalipid may also reduce the risk of heart attack or stroke in patients with risk factors for heart disease. This drug is slightly more popular than comparable drugs. It is available in generic and brand versions.

Other names for this medication:
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Also known as: Simvastatin


Actalipid (simvastatin) belongs to a group of drugs called HMG CoA reductase inhibitors, or "statins."

Actalipid is used to lower blood levels of "bad" cholesterol (low-density lipoprotein, or LDL), to increase levels of "good" cholesterol (high-density lipoprotein, or HDL), and to lower triglycerides (a type of fat in the blood).

Actalipid is also used to lower the risk of stroke, heart attack, and other heart complications in people with diabetes, coronary heart disease, or other risk factors.

Actalipid is used in adults and children who are at least 10 years old.


Take Actalipid exactly as prescribed. Follow all directions on your prescription label. Never take this medicine in larger amounts, or for longer than prescribed. Taking too much of this medication may cause serious or life-threatening side effects.

Actalipid is usually taken at bedtime or with an evening meal. If you take this medicine more than once daily, take it with meals. Your doctor may occasionally change your dose to make sure you get the best results.

While using Actalipid, you may need frequent blood tests at your doctor's office.

You may need to take Actalipid on a long-term basis for the treatment of high cholesterol. You may need to stop using this medicine for a short time if you have surgery or a medical emergency. Do not stop taking this medicine unless your doctor tells you to.

Actalipid is only part of a complete program of treatment that also includes diet, exercise, and weight control. Follow your diet, medication, and exercise routines very closely.

Store at room temperature away from moisture, heat, and light.

Detailed Actalipid dosage information


If you overdose Actalipid and you don't feel good you should visit your doctor or health care provider immediately.


Store at room temperature below 30 degrees C (86 degrees F) away from moisture and heat. Keep container tightly closed. Throw away any unused medicine after the expiration date. Keep out of the reach of children.

Side effects

The most common side effects associated with Actalipid are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


Grapefruit and grapefruit juice may interact with simvastatin and lead to unwanted side effects. Avoid the use of grapefruit products while taking Actalipid.

Avoid eating foods that are high in fat or cholesterol. Actalipid will not be as effective in lowering your cholesterol if you do not follow a cholesterol-lowering diet plan.

Avoid drinking alcohol. It can raise triglyceride levels and may increase your risk of liver damage.

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Note: a simple correlation to locate the three phase coexistence line in methane-hydrate simulations. Results suggest that the effect of mixed borders is largely limited to dispersal by walking and does not apply to beetles leaving host patches by flight. Compilation and characterization of Arabidopsis thaliana response regulators implicated in His-Asp phosphorelay signal transduction. This predominance was of individual character in cases of conductive hypoacusis. These findings suggest that a stable Cse4 nucleosome is maintained by dynamic chaperone-in-residence Scm3.DOI: The enzyme may have anti-tumour and anti-inflammatory effects in colon and its levels are decreased in patients with colon cancer and ulcerative colitis. Hemophagocytic lymphohistiocytosis (HLH) is a life- threatening hyperinflammatory disease that causes extensive organ damage. Information on turnover and costs is needed to develop strategies that retain nurses as knowledge-based workers.

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While rare, lipomas should be included in the differential diagnosis of CPA and IAC lesions. We also evaluated marital status, ethnicity, birthplace and methods for suicide. The production, isolation, structure determination as well as the physical, spectroscopic and antibacterial properties of this C13H17NO3S compound are here reported. In the isolated IOLs, 70 mJ of energy deformed and partially melted both polymethylmethacrylate (PMMA) and polypropylene haptics. Fluoride pharmacokinetics in good and poor responders to fluoride therapy.

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Lateral meniscal cyst presenting as Medial Compartment Knee Swelling: A case report and literature review. We suggest that this age range may constitute a sensitive period for the acquisition of sexual preferences. The amine groups originating from the intercalated dendrimer molecules cross-link adjacent GO sheets and strongly favour CO2 adsorption under wet flue gas conditions. However, the applied heat can cause detrimental effects on health-promoting components such as phenolic compounds. The extract of Serenoa repens (SABA Lampugnani Farmaceutici S.p.A.) administered at the dose of 320 mg/day to patients with benign prostatic hypertrophy, is effective in terms of improvement of the functional symptomatologic picture improvement and of the instrumental parameters with a good tolerability profile. Computer simulations show that the proposed approach can achieve better bias versus variance trade-off and higher contrast recovery for dynamic PET image reconstruction than the conventional maximum likelihood method with and without post-reconstruction denoising. Both groups of rats were injected subcutaneously with 5 micrograms/100 g of estradiol benzoate (E2) in corn oil vehicle at 08.00 h, 1 and 2 days before serum collection and 5 mg/100 g of progesterone (P) in corn oil vehicle at 07.00 h on the day of serum collection. We found that on 2D surfaces, the cells were scarcely distributed and showed limited formation of lipid droplets, whereas cells grown in macroporous 3D scaffolds contained more cells growing in clusters, containing large lipid droplets. Infantile hypertrophic pyloric stenosis (IHPS) is a multifactorial heritable condition affecting infants in the first 3 months of life.

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Comparison between a new once-daily, bronchodilating drug, bambuterol, and terbutaline sustained-release, twice daily. Kinetochore staining in multicentric chromosomes of murine cancer cell lines. Gestation-specific D-dimer reference ranges: a cross-sectional study. For patients with severe deformity, the lateral approach may be used for anterior column support and to augment arthrodesis. There was a slight, but not significant increase in cardiac index. The absolute number of patients is likely to increase with the growth of radiation therapy to treat breast cancer. When compared with self-rated measures, adult-rated Conscientiousness and Openness were more strongly correlated with academic performance, but adult-rated Agreeableness was less strongly correlated. Pneumoperitoneum in healthy humans does not affect central blood volume or cardiac output.

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We show here, however, that models for branched complex systems are sometimes obtained that violate the stoichiometry of fluxes at branch points and as a result give unrealistic metabolite concentrations at the steady state. Average values of the effect of increasing stimulus rate were calculated as well. Thus, this system offers the opportunity to switch the bridges on and off and to tune precisely the bridge volume by altering the temperature in a convenient range. The role of nuclear medicine diagnostic bone scanning is well established in prostate cancer. Highly reflective Bragg gratings in slightly etched step-index polymer optical fiber. Measurement of human embryo-derived platelet-activating factor (PAF) using a quantitative bioassay of platelet aggregation. We have proven that reduced activity of mixed function monooxygenase is related only to diminished glycogen content of the liver. Clinical experience with extracorporeal shock wave lithotripsy (ESWL) in upper urinary tract stones.

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Medical emergency teams (MET) are established at several Danish hospitals. In addition, these results suggest that bovine milk contains active substances that inhibit both adhesion of Helicobacter pylori to mucosa and vacuole formation. The recombinant product of the alternative transcript specifically binds to HER-2-transfected cells with a K(D) of approximately 14 nM and was chemically crosslinked to p185HER-2, whereas the intron encoded sequence alone also binds with high affinity to transfected cells and associates with p185 solubilized from cell extracts. The usefulness and limitations of the nonisothermal method, as predicted by computer simulation, were validated. The intraclass correlation coefficient (ICC) was calculated to assess the reliability of the datasets. Radiography and computed tomography (CT) revealed nodules in the caudal esophagus.

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We employed gradient echo planar imaging (EPI) with repetition times of 3s and used simultaneous recordings of physiological parameters. Two interacting factors, Dom34 and Hbs1, are genetically implicated in NGD in yeast. Effect of codeine and loperamide on upper intestinal transit and absorption in normal subjects and patients with postvagotomy diarrhoea. The speed of oxygen consumption by isolated wound tissue was determined simultaneously. This rare, but potentially fatal reaction has not previously been reported with a PUREMA filter and this case should raise awareness of hypersensitivity reactions with this widely used method of renal replacement therapy.

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avium is very often linked with acquired immune deficiency syndrome-associated opportunistic infections. The present study, carried out on isolated tracheal muscle strips of guinea pigs, was designed to explore this controversy. In period I (1978-1979), the supervisory staff were inside the hospital from 07.01 to 17.00 hours, and on call at home from 17.01 to 07.00 hours of the next day, and in period II (1980-1981), the supervisory staff were inside the hospital 24 h a day. Influence of ampicillin, clindamycin, and metronidazole on faecal excretion of short-chain fatty acids in healthy subjects. Formation and stability of vincristine-tubulin complex in kidney cytosols. In the following decade ioMRI and image guided surgery has evolved from an experimental stage into a safe and routinely clinically applied technique. Normalization and improvement of CNS deficits in mice with Hurler syndrome after long-term peripheral delivery of BBB-targeted iduronidase. Thirty patients were enrolled, including 27 patients with stage IV disease, and 11 patients with performance status of 2. IFCC method for creatine kinase (ATP: creatine N-phosphotransferase, EC

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Riboflavin-free media is recommended for solar radiation investigations to eliminate concerns regarding riboflavin photosensitisation and nutrient deprivation. These in vitro results correlate with the in vivo findings that in lyn-/- mice, IgG1 Ab-forming cells develop prematurely in ontogeny and that adult lyn-/- mice have an abnormally high proportion of IgG1-expressing B cells in their spleens. Phytophthora foot rot of black pepper caused by Phytophthora capsici is a major disease of black pepper (Piper nigrum) throughout Vietnam. Minimal Fokker-Planck theory for the thermalization of mesoscopic subsystems. This study is among the first to implement and evaluate automated collection of data from patients at these clinics. After the infusion of BCAA-enriched amino acid solution, the BTR increased substantially, being significantly higher in patients who had not suffered an elevation in total bilirubin after liver resection.

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Despite plausible biologic mechanisms linking increased physical activity to decreased risk for renal cancer, few epidemiologic studies have been able to report a clear inverse association between physical activity and renal cancer, and no meta-analysis is available on the topic. These results suggest that the inhibitory effects of TNF on cutaneous tissue repair are mediated in part by IL-1. A Portable, Pressure Driven, Room Temperature Nucleic Acid Extraction and Storage System for Point of Care Molecular Diagnostics. Photo-ionization and photo-excitation of curcumin investigated by laser flash photolysis. There is currently intense interest in unravelling the modus operandi of type I modular polyketide synthases in order to lay the ground work for their use in the combinatorial biosynthesis of new bioactive molecules. In the two peaks pattern, another absorption peak appeared at 670nm, with the absorption shoulder from 350 to 450 nm, and shared the absorption characteristics of phycocyanin and chlorophyll complex protein. About 4 min is required for an exhaustive search of a 1500-base nucleotide sequence against all mammalian sequences (1.2M bases) in Genbank Ver.

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Xylazine (3 x 10(-5) M--4 x 10(-3) M) failed to induce platelet aggregation in vitro. Coverage of the positive effect of quality improvement efforts of managed care organizations (MCOs) and hospitals, however, has been practically nonexistent. A preoperative computed tomography (CT) scan demonstrated an enhancing lesion extending extra-abdominally from the region of the external inguinal ring. Here we examine early land plant evolution using complete plastome sequences including two previously unexamined and phylogenetically critical lineages. Furthermore, an interaction existed between the trait anxiety and optimism for some dimensions of SF36. To further reduce case fatality, health authorities need to ensure that SC/ST are targeted by the immunization programme and that outbreak investigations target for vitamin A treatment of cases in high risk groups such as SC/ST and young children and ensure regular visits by health-workers in affected villages to administer vitamin A to new cases. However, the integration of devices with the biological milieu is still a fundamental issue to be addressed.

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The protein complexes in the thylakoid membrane are composed of subunits derived from both the nuclear and chloroplast genomes. Development of a new technique for the efficient delivery of aerosolized medications to infants on mechanical ventilation. Before the advent of oral, targeted anticoagulants, physicians had no choice regarding the type of oral anticoagulant prescribed, as every patient received warfarin. Significant agreement on positive LNs and TDs in difficult colonic adenocarcinoma metastases was found among evaluators, but inconsistency remains. Abnormalities of autonomic function in the Lambert Eaton myasthenic syndrome. However, at the maximum tolerated doses of both drugs (3 mg/kg per injection for doxorubicin and 0.75 mg/kg per injection for idarubicin), the cardiac toxicity of idarubicin remained significantly lower than that of doxorubicin. Transfection studies with the 5-HT1A receptor have generated critical new information that might otherwise have been elusive. In addition, it was possible to prepare monoclonal antibodies that recognized an antigen expressed by TP which was not shared by T. There was evidence for dose-related elimination, with greater elimination of the larger dose. Large individual differences exist in the ability to delay gratification for the sake of satisfying longer-term goals.

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The hyperthyroid cats were diagnosed of about 23,000 cats examined in two internal veterinary clinics Giessen und Munich). The kinetic mechanism and the substrate specificity of liver alcohol dehydrogenase are changed when 3-benzoylpyridine-adenine dinucleotide is used as coenzyme. In this study, a broad investigation of possible causes of DNA degradation during storage was performed, including GC-content of the fragments, long-term storage, rapid freeze-and-thaw experiments, genomic DNA and short DNA fragments of different species, the influence of shear stress and the effect of nuclease remaining after DNA isolation. Previous research has yielded evidence of attentional biases for food-related cues in binge eating disorder (BED) using behavioural measures such as the Stroop and dot probe paradigm. These studies reveal an intricate, multilayered parasite survival strategy involving pseudokinases that regulate multiple active kinase complexes to synergistically thwart innate immunity. Therefore, the model is not active in the usual sense of adding energy to the cochlea. The study investigated the direct effects of tramadol on the coagulation status of women with gynecologic malignancies in vitro. Adult and embryonic skeletal muscle microexplant culture and isolation of skeletal muscle stem cells. Dynamic contrast enhanced magnetic resonance imaging (MRI) has proven to be quite sensitive for the characterization of masses and early response to therapy. Locomotor recovery following subtotal spinal cord lesions in a rat model.

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Factors associated with the suppressiveness of sugarcane soils to plant-parasitic nematodes. The human Tap protein has been proposed to mediate Mason Pfizer monkey virus constitutive transport element (CTE)-dependent nuclear RNA export and may also play a role in global mRNA export. This study assessed incidence, how to use vermox tablets predictive factors, and outcome of Epstein-Barr virus (EBV) DNAemia in 100 recipients of allogeneic hematopoietic stem cell transplant. The findings here suggest that although American Indian children are at higher risk, in general, compared to white children, rural populations in general are experiencing increases in childhood overweight and obesity. Attempts to extract informations on which input descriptors are important using a genetic input selection algorithm failed. Comparative analysis of results of examination and treatment of 54 patients, suffering obturation jaundice syndrome, is presented. Genetic introgression involved multiple exotic source populations of Danubian and Atlantic origin, thus evidencing the negative impact of few decades of stocking. The present results indicate that piperidine can discriminate between the fast transient and slow persistent components of ACh-induced ICl in Aplysia neurons, and also suggest that two components of the desensitization phase of ACh-induced ICl function in an independent manner. A trans-acting mechanism represses the expression of the major transplantation antigens in mouse hybrid thymoma cell lines. Qualitative and quantitative studies of antral and fundic G cells in pernicious anaemia.

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Infrared spectral data of Lophatheri Herba cordarone 200 mg tabletti cluster analysis was applied to explore the similarity between each sample. Previous studies have demonstrated that Friend leukemia virus (FLV) induces a profound immunosuppression in susceptible mice. Working memory inefficiency: minimal information is utilized in visual recognition tasks. Although widely used as an operational marker of proliferation, the cell cycle-regulated Ki67 protein is of unknown function. Quantitative agar gel electrophoresis of human gastric proteinase proenzymes. Glucose infusion as a tonometric loading test in the diagnosis of glaucoma.

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Six patients with calcified transitional cell carcinoma of the renal pelvis were encountered over a 10-year period, and the radiographic features in these cases are presented. Impaired selenoprotein expression in brain triggers striatal neuronal loss leading to co-ordination defects in mice. Synthesis, characterization and opto-electrical properties of ternary Zn2SnO4 nanowires. The distribution patterns of hypothalamocerebellar cortical axons resemble those reported for monoaminergic fibers in the cerebellar cortex. The number of patches also increases with increasing the wall selectivity. Towards global benchmarking of food environments and policies to reduce obesity and diet-related non-communicable diseases: design and methods for nation-wide surveys. The article analyzes the incidence of Sarcoma Kaposi in Norway during the period 1957-86 (30 years). Apparent N1m responses were observed despite total absence of the ABR or absence except for small wave I in all patients, although the latency of N1m was delayed in most patients. Resting and reactive hyperemic leg blood flows are significantly reduced in the paretic compared with the nonparetic limb after disabling stroke. Rapid kinetic characterization of glycosyl hydrolases based on oxime derivatization and nanostructure-initiator mass spectrometry (NIMS).

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Autonomic function was evaluated by the standard cardiovascular reflex tests and 24-hour heart rate variability measurement. Diagnosis, treatment and prevention are not always straightforward, although recent developments offer hope for improved options in future. Finally, childhood stress is related to an increased risk of developing MD such as depression, bipolar disorder, schizophrenia and substance abuse. The development of highly efficient, stable and environmentally-benign catalysts for SCR processes is very important for practical use. With due attention to the 5-HT3 receptor antagonists, both the change from injections to oral drugs and the change from brand-name drugs to generic drugs were tried between July 2008 and June 2009.

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Values of symptom index and symptom association proba-bility for acid and non acid reflux were transformed into binary response (i.e., positive or negative). Importantly, Ganetespib is active on B-RAF mutated melanoma cells that have acquired resistance to B-RAF inhibition. These results, however, will need to be further examined in future large prospective studies. During the same stage of memory retrieval participants carrying a rarer A variant exhibited an atypical pattern of brain activity, a topographically dissociable frontally-distributed old/new effect, even though behavioural performance did not differ between groups. Because of its observational nature, this study requires future research to confirm these intriguing findings. Typhoid, which is caused by Salmonella enterica serovar Typhimurium, remains a major health concern worldwide. Suicide rates by each major method of suicide are presented for 16 countries in 1960-1964 and in 1980.

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We conclude that echocardiography eliminates the need for invasive preoperative diagnostic procedures in selected neonates with congenital aortic arch obstruction. Fermentative production of bio-H2 can be a promising technique for concomitant generation of an electron source for hydrogen driven remediation strategies and treatment of organic residue in marine ecosystems. Hemangiomas of spinal nerve roots pose a challenging diagnostic problem. A comparison of the growth characteristics of samples of muscle from 30 patients (including some noroxin drug control samples) indicated that although muscle from younger patients (less than 14 years) regenerated more quickly, the myotubes did not have better differentiation. Post-operative cervical MRI showed a complete removal of the spinal dysraphism, fistula, and intramedullary abscess. Six patients were operated at 15 levels using psoas muscle retraction technique.

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This mechanism likely contributes to the regulation of processes beyond those of female reproduction. Antiplatelet and direct antithrombin agents may be useful in the prophylaxis of IE in humans. Collected data included surgical blood loss, perioperative complications (wound infection, vascular injury, approach-related complications, and neurological injury), need for secondary procedures, microbiological and laboratory results, and efficacy of infection eradication. The first four principal components represented the major axes of variation in foot morphology: low-arched versus high-arched feet, long and narrow versus short and wide feet, the relative length of the hallux, and the relative length of the forefoot. False diagnoses often lead to patients suffering from symptoms for periods of months or even years, which imposes significant limitations on their tramadol cost working and private lives. In this paper we discuss novel MR imaging blood pool agents characterized by new pharmacokinetic properties. The traumatic SAH is the common manifestation of head injury and difficult to make a diagnosis in forensic investigation. Animal studies have indicated since that KW-2149-induced pulmonary toxicity can be prevented by pretreatment with corticosteroids.

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Such a differential regulation of MMP and TIMP by TGF-beta may influence the rate of extracellular matrix (ECM) turnover following tissue injury, induced during myomectomy and Caesarean section, or in leiomyomas during growth. In the influenza H5N1 virus incident in Hong Kong in 1997, viruses that are closely related to H5N1 viruses initially isolated in a severe outbreak of avian influenza in chickens were isolated from humans, signaling the possibility of an incipient pandemic. Histones in chromatin appeared less accessible to carbamoylation than isolated histones. Structure of cell wall lipopolysaccharide from Salmonella typhimurium. Homer protein family regulation in skeletal muscle and neuromuscular adaptation. She had a 2-day history of fever, lower back and abdominal pain, dysuria, and constipation. It has been shown that vasotec brand name EOCs express CD40, whereas platelets represent the major source of its soluble ligand (sCD40L), which impairs EOC function.We aimed to test the hypothesis that the sCD40L/CD40 axis affects the anti-platelet function of EOCs. The cytoplasm was rather eosinophilic, PAS-negative, and stained red or yellow by AZAN. Androgen-dependent nitric oxide release in rat penis correlates with levels of constitutive nitric oxide synthase isoenzymes. Hemi-arthroplasty of the hip followed by ipsilateral fracture of the femoral shaft.

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