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Acesistem (Amiloride)
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Acesistem

Acesistem is a new, orally administered, potassium-sparing diuretic with mild natriuretic and diuretic properties. Its primary site of action is the distal tubule of the nephron where it selectively blocks sodium transport, thereby inhibiting sodium-potassium exchange.

Other names for this medication:
Amiloretic, Aquazide, Benazeplus, Bifrizide, Bihasal, Cibadrex, Coteveten, Crinoretic, Disothiazide, Dociteren, Emcoretic, Epratenz, Eprosartan, Esidrix, Fosicomb, Fosicombi, Fosicomp, Hidroronol, Hidrosaluretil, Hydrene, Hydrex, Lispirl, Nefrix, Olina, Quinaretic, Ridaq, Triamizide, Triampur, Turfa

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Also known as: Amiloride

Description

Hydrochlorothiazide is a thiazide diuretic (water pill) that helps prevent your body from absorbing too much salt, which can cause fluid retention.

Amiloride is a potassium sparing-diuretic that also prevents your body from absorbing too much salt and keeps your potassium levels from getting too low.

The combination of hydrochlorothiazide and amiloride is used to treat fluid retention (edema) and high blood pressure (hypertension).

Dosage

Take Acesistem by mouth with food. Acesistem may increase the amount of urine or cause you to urinate more often when you first start taking it. To keep this from disturbing your sleep, try to take your dose before 6 pm. If you want to achieve most effective results do not stop taking Acesistem suddenly.

Overdose

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Storage

Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F) away from moisture, light and heat. Do not freeze. Keep container closed tightly. Throw away any unused medicine after the expiration date. Keep out of the reach of children.

Side effects

The most common side effects associated with Acesistem are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

You should not use this medication if you are allergic to hydrochlorothiazide or amiloride, or if you have:

kidney disease or are unable to urinate; high potassium levels (hyperkalemia); or if you are taking potassium supplements.

Some medicines can cause unwanted or dangerous effects when used with Acesistem 5-50. Your doctor may need to change your treatment plan if you use potassium supplements or certain diuretics (spironolactone, triamterene).

If you have diabetes, do not use Acesistem 5-50 together with any medication that contains aliskiren (Amturnide, Tekturna, Tekamlo, Valturna).

To make sure Acesistem 5-50 is safe for you, tell your doctor if you have:

high cholesterol, heart disease, coronary artery disease; cirrhosis or other liver disease; glaucoma; a breathing disorder; gout; or an allergy to sulfa drugs or penicillin.

This medication is not expected to be harmful to an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment.

Hydrochlorothiazide can pass into breast milk and may harm a nursing baby. You should not breast-feed while you are using hydrochlorothiazide and amiloride.

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